Table 1 Comparison of demographics, diagnoses and outcomes between patients with and without asparaginase hypersensitivity to at least one form of asparaginase
From: HLA alleles associated with asparaginase hypersensitivity in Chinese children
Asparaginase hypersensitivity N = 71 | No asparaginase hypersensitivity N = 36 | p values | |
|---|---|---|---|
Demographics | |||
Median age at diagnosis (years, interquartile ranges) | 4.6 (2.2–12.0) | 6.1 (2.1–14.1) | 0.53 |
Male (%) | 47 (66.2) | 22 (61.1) | 0.67 |
Other allergies# | 10 (14.8) | 1 (2.8) | 0.09 |
Drug hypersensitivity | 6 | 1 | – |
Asthma | 2 | 0 | – |
Eczema | 2 | 0 | – |
Allergic rhinitis | 2 | 0 | – |
Food allergy | 1 | 0 | – |
Diagnoses | |||
B lineage ALL (%) | 54 (76.1) | 23 (63.9) | 0.25 |
B cell ALL (%) | 46 (64.8) | 16 (44.4) | 0.06 |
Infant ALL (%) | 5 (7.0) | 5 (13.9) | 0.30 |
Ph + ALL (%) | 3 (4.2) | 2 (5.6) | 0.99 |
T cell ALL (%) | 10 (14.1) | 7 (19.4) | 0.58 |
Mixed phenotype acute leukaemia (%) | 2 (2.8) | 4 (11.1) | 0.18 |
T cell lymphoma (%) | 5 (7.0) | 2 (5.6) | 0.99 |
Outcomes | |||
Disease relapse (%) | 37 (52.1) | 18 (50.0) | 0.84 |
BMT (%) | 34 (47.9) | 16 (44.4) | 0.84 |
Death (%) | 22 (31.0) | 13 (36.1) | 0.66 |