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Table 1 Biomarkers and characteristics of MSCs derived from different sources

From: Mesenchymal stem/stromal cells in cancer therapy

MSCs isolated from different sources

Presence

Absence

Characteristics

References

Bone marrow

CD13, CD44, CD73, CD90, CD105, CD166, STRO-1

CD14, CD34, CD45, HLA-DR

Confirmed safety

[184,185,186]

   

Capacity to differentiate into hepatocyte

 

Adipose tissue

CD71, CD9, CD13, CD29, CD44, CD54, CD73, CD90, CD105, CD106, CD146, CD166, HLA I, STRO-1

CD14, CD19, CD31, CD34, CD45, CD133, HLA-DR

Abondance in adipose tissue

[184, 187,188,189,190]

   

Have weaker differentiating potential towards osteocytes and chondrocytes

 

Birth-derived tissues

CD29, CD44, CD73, CD90, CD105, CD146

CD14, CD34, CD45

Have relatively high proliferation rate

[191,192,193]

   

Produce more insulin than bone marrow MSC

 

Dental pulp

CD29, CD44, CD90, CD105

CD14, CD34, CD45

Have odontoosteogenic properties

[194,195,196]

   

Locate within the dental crown

 

Peripheral blood

CD44, CD54, CD90, CD105, CD166, HLA-ABC

CD14, CD34, CD45, CD31

Manifest similar immunophenotypes and differentiation potential to those of bone marrow MSC

[197,198,199]

   

The volume of blood is large

 

Endometrium

CD73, CD90, CD105, CD146

CD34, CD45

Have the potential of mesodermal lineage differentiation

[197, 200, 201]

   

Producing high level of leukemia inhibitory factors

 

Skin

CD44, CD73, CD90, CD105, CD166, CD29

CD34, CD45, HLA-DR

Have higher proliferation rate than that of adipose MSC

(202,203,204)