Table 12 Fatal AOEs and patient baseline characteristics
Fatal event | Fatal PT | Other AOE PTs reported | CML/ALL status | History of CV events | CV risk factors at baseline |
|---|---|---|---|---|---|
Bradycardiac arrest | Cardiac arrest | Cardiac arrest Dry gangrene Peripheral ischemia | CML | Congestive heart failure Hypertension Impaired diastolic filling pattern Left atrium enlargement Mild tricuspid regurgitation Mitral valve calcification without significant mitral stenosis Intermittent ventricular tachycardia | Obesity Diabetes mellitus Arterial hypertension |
Cardiac failure | Cardiac failure | Myocardial infarction Coronary artery disease Pulmonary embolism | CML | Pericarditis Ischemic heart failure | |
Intracranial hemorrhage | Hemorrhage intracranial | CML | Aortic stenosis Calcified mitral annulus | ||
Worsening of congestive heart failure | Cardiac failure congestive | Myocardial infarction Deep vein thrombosis | QTc prolongation with nilotinib use Stent placement Congestive heart failure Myocardial infarction Coronary artery disease Mitral regurgitation Trace of tricuspid valve regurgitation | Hyperlipidemia Arterial hypertension | |
Superior mesenteric artery occlusion | Mesenteric arterial occlusion | Celiac artery occlusion | ALL | Paroxysmal atrial fibrillation Thrombophlebitis Bilateral leg deep vein thrombosis Cardiac catheterization | Hyperlipidemia Arterial hypertension |
Cardiac arrest | Cardiac arrest | Peripheral vascular disorder | ALL | Greater saphenous vein thrombosis and cellulitis Aortic valve slightly thickened Left axis deviation Left bundle branch block Hypertension Mild aortic regurgitation Mild pulmonic valve regurgitation Mild to moderate tricuspid regurgitation | Arterial hypertension |
Hemorrhagic cerebral infarction | Hemorrhagic cerebral infarction | Cerebral artery stenosis (2 events) Cerebral infarction (2 events) | CML | Diabetes mellitus Arterial hypertension | |
Cardiac arrest | Cardiac arrest | CML | |||
Cardiac arrest | Cardiac arrest | CML | Ischemic heart disease Angina pectoris | Coronary artery disease Type 2 diabetes mellitus Hypertension | |
Congestive heart failure | Cardiac failure congestive | CML | |||
Stroke | Cerebrovascular accident | Acute myocardial infarction (2 events) | CML | Ischemic stroke Ischemic heart disease Coronary artery disease Revascularization and coronary stent placement | Diabetes mellitus Arterial hypertension Hypercholesterolemia |