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Table 12 Fatal AOEs and patient baseline characteristics

From: Retrospective analysis of arterial occlusive events in the PACE trial by an independent adjudication committee

Fatal event Fatal PT Other AOE PTs reported CML/ALL status History of CV events CV risk factors at baseline
Bradycardiac arrest Cardiac arrest Cardiac arrest
Dry gangrene
Peripheral ischemia
CML Congestive heart failure
Hypertension
Impaired diastolic filling pattern
Left atrium enlargement
Mild tricuspid regurgitation
Mitral valve calcification without
significant mitral stenosis
Intermittent ventricular tachycardia
Obesity
Diabetes mellitus
Arterial hypertension
Cardiac failure Cardiac failure Myocardial infarction
Coronary artery disease
Pulmonary embolism
CML Pericarditis
Ischemic heart failure
 
Intracranial hemorrhage Hemorrhage intracranial   CML Aortic stenosis
Calcified mitral annulus
 
Worsening of congestive heart failure Cardiac failure congestive Myocardial infarction
Deep vein thrombosis
  QTc prolongation with nilotinib use
Stent placement
Congestive heart failure
Myocardial infarction
Coronary artery disease
Mitral regurgitation
Trace of tricuspid valve regurgitation
Hyperlipidemia
Arterial hypertension
Superior mesenteric artery occlusion Mesenteric arterial occlusion Celiac artery occlusion ALL Paroxysmal atrial fibrillation
Thrombophlebitis
Bilateral leg deep vein thrombosis
Cardiac catheterization
Hyperlipidemia
Arterial hypertension
Cardiac arrest Cardiac arrest Peripheral vascular disorder ALL Greater saphenous vein thrombosis and cellulitis
Aortic valve slightly thickened
Left axis deviation
Left bundle branch block Hypertension
Mild aortic regurgitation
Mild pulmonic valve regurgitation
Mild to moderate tricuspid regurgitation
Arterial hypertension
Hemorrhagic cerebral infarction Hemorrhagic cerebral infarction Cerebral artery stenosis (2 events)
Cerebral infarction (2 events)
CML   Diabetes mellitus
Arterial hypertension
Cardiac arrest Cardiac arrest   CML   
Cardiac arrest Cardiac arrest   CML Ischemic heart disease
Angina pectoris
Coronary artery disease
Type 2 diabetes mellitus
Hypertension
Congestive heart failure Cardiac failure congestive   CML   
Stroke Cerebrovascular accident Acute myocardial infarction (2 events) CML Ischemic stroke
Ischemic heart disease
Coronary artery disease Revascularization and coronary stent placement
Diabetes mellitus
Arterial hypertension
Hypercholesterolemia
  1. ALL acute lymphocytic leukemia, AOE arterial occlusive event, CML chronic myeloid leukemia, CV cardiovascular, PTs preferred terms