Targeting PARP proteins in acute leukemia: DNA damage response inhibition and therapeutic strategies

Table 1 Biological function and enzymatic activity of PARP proteins in eukaryotic cells

PARP	Enzymatic activity	Biological function	References
PARP1	Poly-	DDR	[1]
PARP2	Poly-	DDR	[1]
PARP3	Mono-	DDR and mitosis regulation	[9]
PARP4	Poly-	Antiviral response	[10]
TNSK1 PARP5a	Poly-	DDR, telomere maintenance and mitosis regulation	[11]
TNSK2 PARP5b	Poly-	DDR, telomere maintenance and mitosis regulation	[12]
PARP6	Mono-	Cell cycle progression	[13]
PARP7	Mono-	Cell–cell adhesion, inhibition of type I interferon response and gene regulation	[14]
PARP8	Mono-	Unknown	–
PARP9	Inactive	DDR, gene transcription and antiviral response	[15]
PARP10	Mono-	binding protein and an inhibitor of MYC with inhibitory potential also on the NF-κB signaling pathway	[16, 17]
PARP11	Mono-	Role in nuclear envelope biology	[17]
PARP12	Mono-	Regulation of stress granule assembly, microRNA activity and antiviral response	[18, 19]
PARP13	Inactive	Regulation of microRNA activity	[20]
PARP14	Mono-	Survival, cell migration, assembly of stress granules, transcription during inflammation processes, DDR and antiviral response	[21, 22]
PARP15	Mono-	Regulation of stress granule and antiviral response	[10, 22]
PARP16	Mono-	Regulation of unfolded protein response	[23, 24]

ISSN: 1756-8722