Fig. 2

ST analysis of BC-A and cell type deconvolution. a Scaled deconvolution values for six epithelial subclusters overlaid onto tissue spots. b Different spatial distribution of six groups as defined in a. c Heatmap of estimated scores of immune cells in each group by MCPcounter. d Heatmap of the ssGSEA score of six gene signatures estimated in each METABRIC sample. e Kaplan–Meier survival curve for METABRIC cohort in three groups. P value was calculated with log-rank test. Log-rank p value < 0.05 was considered as statistically significant. f Box plot of the estimated proportion of six gene signatures in two NAC cohorts using CIBERSORTx. Statistical significance was determined using a two-sided t-test in a pairwise comparison of means between groups, with P values adjusted using the Benjamini–Hochberg procedure. *P < 0.05, **P < 0.005, ***P < 0.005