Table 2 Major regimens used in NK/T-cell lymphomas, listed in alphabetical order according to acronyms
Regimens | Drugs and schedule | References |
|---|---|---|
AspaMetDex | E. coli L-asparaginase: 6000 U/m2, IM, days 2, 4, 6, 8 | [73] |
Methotrexate: 3000 mg/m2, IV, day 1 | ||
Dexamethasone: 40 mg, oral, days 1–4 | ||
DDGP | Dexamethasone: 15 mg/m2, IV, days 1–5 | [76] |
Cisplatin: 20 mg/m2, IV, days 1–4 | ||
Gemcitabine: 800 mg/m2, IV, days 1, 8 | ||
Pegaspargase: 2500 IU/m2, IM, day 1 | ||
DeVIC (2/3) | Dexamethasone: 40 mg, IV, days 1–3 | [57] |
Etoposide: 67 mg/m2, IV, days 1–3 | ||
Ifosfamide: 1000 mg/m2, IV, days 1–3 | ||
Carboplatin: 200 mg/m2, IV, day 1 | ||
DICE-L-asp | Dexamethasone: 20 mg/m2, days 1–4 | [69] |
Ifosfamide: 1200 mg/m2, IV, days 1–3 | ||
Cisplatin: 25 mg/m2, IV, days 1–4 | ||
Etoposide: 60 mg/m2, days 1–4 | ||
L-asparaginase: 6000 U/m2, days 6–11 | ||
GELAD | Gemcitabine: 1000 mg/m2, IV, day 1 | [70] |
Etoposide: 60 mg/m2, IV, days 1–3 | ||
Pegaspargase: 2000 U/m2, day 5 | ||
Dexamethasone: 40 mg, days 1–4 | ||
GELOX | Gemcitabine: 1000 mg/m2, IV, days 1, 8 | [66] |
E. coli L-asparaginase: 6000 U/m2, IM, days 1–7 | ||
Oxaliplatin: 130 mg/m2, IV, day 1 | ||
LVP | L-asparaginase: 6000 IU/m2, IV, days 1–5 | [63] |
Vincristine: 1.4 mg/m2, IV, day 1 | ||
Prednisolone: 100 mg, oral, days 1–5 | ||
MEDA | Methotrexate: 3000 mg/m2, IV, day 1 | [74] |
Etoposide: 100 mg/m2, IV, days 2–4 | ||
Dexamethasone: 40 mg, IV, days 2–4 | ||
Pegaspargase: 2500 U/m2, day 4 | ||
MESA | Methotrexate: 1000 mg/m2, IV, day 1 | [30] |
Etoposide: 100 mg/m2, days 2–4 | ||
Dexamethasone: 40 mg, IV, days 2–4 | ||
Pegaspargase: 2500 U/m2, IM, day 4 | ||
P-GEMOX | Pegaspargase: 2500 IU/m2, IM, day 1 | [67] |
Gemcitabine: 1000 mg/m2, IV, days 1, 8 | ||
Oxaliplatin: 130 mg/m2, IV, day 1 | ||
SMILE | Dexamethasone: 40 mg, IV or oral, days 2–4 | [62] |
Methotrexate: 2000 mg/m2, IV, day 1 | ||
Ifosfamide: 1500 mg/m2, IV, days 2–4 | ||
E. coli L-asparaginase: 6000 U/m2, IV, days 8, 10, 12, 14, 16, 18, 20 | ||
Etoposide: 100 mg/m2, IV, days 2–4 | ||
VIDL | Etoposide: 100 mg/m2, IV, days 1–3 | [60] |
Ifosfamide: 1200 mg/m2, IV, days 1–3 | ||
Dexamethasone: 40 mg, IV, days 1–3 | ||
L-asparaginase: 4000 IU/m2, IM, days 8, 10, 12, 14, 16, 18, 20 | ||
VIPD | Etoposide: 100 mg/m2, IV, days 1–3 | [59] |
Ifosfamide: 1200 mg/m2, IV, days 1–3 | ||
Cisplatin: 33 mg/m2, IV, days 1–3 | ||
Dexamethasone: 40 mg, IV or oral, days 1–4 |