Table 3 pH-responsive building blocks for tumor treatment
pH-sensitive building block | Therapeutic agent | Tumor model | Therapeutic application | Refs. |
|---|---|---|---|---|
Poly(2-(hexamethyleneimino)ethyl methacrylate | siBRD4-loaded TCPA2-NPs | Prostatic cancer | LNCaP-bearing mouse GT | [477] |
| Â | HRNMs | Glioblastoma | Chemotherapy | [478] |
Poly(diisopropanol amino ethyl methacrylate) | GPDPA NPs | Glioblastoma | Chemotherapy PTT | [479] |
Benzoic-imine bond | CA-MTX NPs | Cervical carcinoma | Chemotherapy | [480] |
| Â | nBSA-Dox | Hepatocellular carcinoma | Chemotherapy | [481] |
|  | NdIIIIP-N = CH-PEG | Cervical carcinoma | Chemotherapy PTT | [482] |
| Â | DOX-ICM | Glioblastoma | Chemotherapy | [483] |
| Â | Au@PP/RA/siRNA | Pancreatic cancer | Chemotherapy | [484] |
Pyridine-2-imine | Gold nanomachine | Breast cancer | PTT | [485] |
| Â | PMNP-DOX@RBC | Breast cancer | Chemotherapy, CDT | [486] |
Amide bond | DOX-CC-NP | Squamous cell carcinoma | Chemotherapy | [19] |
| Â | PDNBF NPs | Breast cancer | Chemotherapy PTT | [487] |
Nanodrug complex | MONCs | Breast cancer | Chemotherapy PDT | [488] |
| Â | B780/Qu NPs | Breast cancer | Chemotherapy PDT, PTT | [98] |
Gadolinium oxide | Gd2O3 NSs | Melanoma | Chemotherapy | [489] |
| Â | FS-GdNDs | Breast cancer | PTT | [490] |
Triplex DNA sequence | NLNs/DOX | Breast cancer | Chemotherapy | [491] |
| Â | DNA Conjugated AuNPs | Breast cancer | Chemotherapy PTT | [492] |