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Fig. 5 | Journal of Hematology & Oncology

Fig. 5

From: Somatic copy number alteration and fragmentation analysis in circulating tumor DNA for cancer screening and treatment monitoring in colorectal cancer patients

Fig. 5

LIFE-CNA enables accurate disease monitoring in CRC patients. SCNAs, focal SCNAs (foc. SCNA), tumor fraction in all (tum. frac.) and filtered fragments (tum. frac. short), enrichment in fragments from 90 to 150 bp (glob. frag.), regional fragmentation (reg. frag.), and significantly stronger coverage drops (low cov.) were analyzed with LIFE-CNA. In addition ctDNA was predicted with machine learning classifiers based on global (ML glob. frag.) and regional fragmentation (ML reg. frag.), and a meta-learner (ML Meta.) integrated into LIFE-CNA. To assess performance of LIFE-CNA, hotspot variants (SNVs) cfDNA concentration (cfDNA) and CEA were analyzed A in samples from CRC patients collected at different time points during disease summarized over all samples and B stratified by disease stage. C LB-CRC-32 was used as one example to show response and resistance to treatment throughout the course of disease

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Journal of Hematology & Oncology

ISSN: 1756-8722

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