Fig. 8

circPDK1 promotes aerobic glycolysis via c-myc activation. The glycolytic genes expressions were evaluated by A qRT-PCR and B Western blotting after loss of circPDK1. C, D Lactate production, E ATP production, F glucose uptake, G OCAR and H ECAR assays were performed to measure the glycolysis level in PC cells after loss of circPDK1. I PET-CT was performed to assess the glucose metabolism in mice subcutaneous tumors. J Proposed model demonstrating that hypoxia-induced exosomal circPDK1 promotes PC tumorigenesis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1. *P < 0.05; **P < 0.01; ***P < 0.001