Fig. 1

A The distribution of 175 participating centers in the provincial-level administrative regions of China. B Flowchart of enrollment, allocation, and study design. C Independent risk factors for colorectal neoplasia in the multivariate logistic regression model and points assigned to the NCPC score. * Points were assigned by dividing the Log-Odds coefficients by the absolute value of the smallest coefficient (BMI 0.163) and rounding up to the nearest integer. D Predicting performance of NCPC score in the derivation cohort, validation cohort, NSGS cohort, and asymptomatic cohort. * No significant differences were found for AUC between derivation and validation cohort (P = 0.80) or between NSGS and asymptomatic cohort (P = 0.31). NCPC, national colorectal polyp care; CEA, carcinoembryonic antigen; FIT, fecal immunochemical test; CRC, colorectal cancer; CN, colorectal neoplasia; OR, odds ratio; CI, confidence interval; BMI, body mass index; FDR, first-degree relative; PNC, previous negative colonoscopy; NSGS, non-specific gastrointestinal symptom; and AUC, area under the receiver operating characteristic curve