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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: SIRPα-Fc fusion protein IMM01 exhibits dual anti-tumor activities by targeting CD47/SIRPα signal pathway via blocking the “don’t eat me” signal and activating the “eat me” signal

Fig. 2

The IMM01 efficacy in combination with PD-L1 mAb (KN035) (A) and PD-L1 mAb (Tislelizumab) (B) on the in-house developed CT26-hPDL1(Tg) hCD47(Tg)mPDL1(KO)mCD47(KO) cell mouse tumor models, with CD33 mAb (Gemtuzumab) on HL-60 xenograft tumor model (C) and Her2 mAb (Inetetamab) on SNU-1 xenograft tumor model (D). It demonstrated that the combination of IMM01 with PD-1 or PD-L1 antibody resulted in significantly stronger antitumor effects than PD-1 or PD-L1 alone (A, B). The efficacy of IMM01 alone and in combination with CD33 mAb and HER-2 mAb in the SNU-1 and HL-60 xenograft models (C, D), respectively, revealed great therapeutic potential in combination with these mAbs

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Journal of Hematology & Oncology

ISSN: 1756-8722

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