Fig. 3

Hypercoagulability in Cancer & SARS-CoV-2. SARS-CoV-2 and cancer stimulate IL-6 secretion which causes endothelial cell dysfunction. This results in increased vascular permeability, complement activation, and inflammatory damage due to secretion of Acute Phase Reactants. Both SARS-CoV-2 and cancer contribute to Virchow’s Triad that, in addition to endothelial cell dysfunction, also includes blood stasis due to prolonged hospitalizations and hypercoagulability due to release of pro-coagulable factors. Ultimately, this results in a hypercoagulable state increasing the risk for DVTs and PEs. The image of SARS-CoV-2 was derived from the Centers for Disease Control and Prevention (CDC) website: https://phil.cdc.gov/Details.aspx?pid=23312