Table 2 Non-tumor-derived exosomal circRNAs in tumor progression

circ_0020256

M2 macrophages

Cholangiocarcinoma cells

↑

circ_0020256/miR-432-5p/E2F3

Promote the proliferation, migration, and invasion of CCA cells

[123]

hsa_circ_0001610

M2 macrophages

Endometrial cancer cells

↑

hsa_circ_0001610/miR-139-5p/cyclin B1

Reduce radiosensitivity of EC cells

[124]

has_circ_0004658

RBPJ-overexpressed macrophages

Hepatocellular carcinoma cells

↓

hsa_circ_0004658/miR-499b-5p/JAM3

Inhibit HCC progression

[127]

circBTG2

RBPJ-overexpressed macrophages

Glioma cells

↑

circBTG2/miR-25-3p/PTEN

Inhibit glioma progression

[128]

circEIF3K

CAFs

Colorectal cancer cells

↑

circEIF3K/miR-214/PD-L1

Promote proliferation, invasion and tube formation of CRC cells

[136]

circHIF1A

CAFs

Breast cancer cells

↑

circHIF1A/miR-580-5p/CD44

Promote breast cancer proliferation and stem cell stemness

[137]

circZFR

CAFs

Hepatocellular carcinoma cells

↑

circZFR/STAT3/NF-κB

Promote HCC growth and CDDP resistance

[138]

circ_0088300

CAFs

Gastric cancer cells

↑

circ_0088300/miR-1305/JAK/STAT

Promote GC cell proliferation, migration and invasion

[14]

circ-DB

Adipocytes

Hepatocellular carcinoma cells

↑

circ-DB/miR-34a/USP7/Cyclin A2

Promote HCC growth and reduce DNA damage

[86]

circ_6790

Bone marrow mesenchymal stem cells

Pancreatic ductal adenocarcinoma cells

↑

circ_6790/CBX7/S100A11

Hamper immune escape in PDAC cells

[141]

circ_0030167

Bone marrow mesenchymal stem cells

Pancreatic cancer

↑

circ_0030167/miR-338-5p/Wif1/Wnt 8/β-catenin

Inhibit the stemness of PC cells and tumor progression

[142]

circ_100395

Adipose-derived mesenchymal stem cells

Non-small cell lung cancer cells

↓

circ_100395/miR-141-3p/Hippo/YAP

Inhibit NSCLC malignant transformation

[143]