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Table 1 Clinical trials on amino acid supplementation

From: Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy

Type of amino acids

Intervention/treatment (design)

Type of cancer

NCT number

Phase

Status

Purpose

Glutamine

Dietary supplement of glutamine

Metastatic cancer

NCT04710290

III

Enrolling

Evaluate the efficacy of glutamine supplementation in patients with metastatic cancers undergoing chemotherapy

Dietary supplement of glutamine

Head and neck cancer

NCT00006994

III

Terminated

Evaluate the efficacy and safety of L-Glutamine upon radiation therapy-induced oral mucositis in head and neck cancer patients

Dietary supplement of standard-glutamine Dietary supplement of standard-glutamine-omega 3

Colorectal cancer

NCT01831310

IV

Completed

Evaluate the effect of postoperative glutamine-dipeptide supplemented parenteral nutrition on neutrophil functions and postoperative course of patients with colorectal cancer

Drug: Glutamine

Colorectal Neoplasms

NCT01087658

III

Completed

Evaluate the efficacy of oral glutamine in the prevention of oxaliplatin-induced neurotoxicity in patients with colorectal cancer treated with oxaliplatin

Drug: Glutamine

Kidney cancer

NCT00365768

II

Completed

Study the effects of glutamine in pediatric patients with cancer

Dietary supplement of glutamine

Unspecified adult solid tumor

NCT00217724

Not Applicable

Terminated

Study how effect glutamine in preventing myalgia and/or arthralgia in patients who are receiving paclitaxel for cancer

Drug: Glutamine

Advanced cancers

NCT01952847

III

Terminated

Study glutamine function in reliving sores, blisters, or inflammation in the mouth or esophagus

Arginine

Dietary supplement of arginine

Head and neck cancer

NCT00559156

II

Completed

Evaluate the impact of arginine for postoperative radio chemotherapy in patients with carcinoma of the head and neck

Drug: oral L-arginine

Prostate cancer

NCT01105130

II

Completed

Study effect of L-arginine supplementation in treating erectile dysfunction and quality of life of prostate cancer survivors previously treated with radiation therapy