Table 3 Representative nanomaterials in treating HMs that stimulate the immune system
Nanomaterials | Payload | Ind. | Outcome | References |
|---|---|---|---|---|
PLA microspheres | PD-1 antibody and leukemia antigen polypeptide pE | Leu | Enhance the APC response, recruit more APC cells, enhance the proliferation of T cells in lymph nodes | [167] |
Hydrogel | Antigen polypeptide WT1126-134 and immune adjuvants (GM-CSF) | Leu | Induce local immune-cell infiltration and activate dendritic cells | [166] |
LNT cells | DOX | Leu | Promote antitumor immune responses | [171] |
HSCs | aPD-1 | Leu | Increase the number of active T cells, produce cytokines and chemokines | [172] |
Lipid-PEG | mRNA, palmitic acid-modified TLR7/8 agonist R848 (C16-R848) | Lyn | Improve the expansion of OVA specific CD8 + T cells | [168] |
PLGA NPs | BCMA72 − 80[YLMFLLRKI] peptide | MM | Increase peptide delivery to human dendritic cells, which enhance induction of BCMA-specific CTL | [169] |