Fig. 2
From: Methyltransferase-like proteins in cancer biology and potential therapeutic targeting
Mechanisms regulating the expression levels of METTL3 and METTL14 and small molecule inhibitors of their complexes. A Molecules that are known to regulate the expression level of METTL3/METTL14. Orange boxes represent regulation of METTL3/METTL14 from the transcriptional level, inhibiting or promoting their transcription; green boxes represent regulation of METTL3/METTL14 from the translational level, inhibiting or promoting their mRNA translation; blue boxes represent regulation of METTL3/METTL14 from the protein level, inhibiting or promoting their protein activity. B Chemical structures of current METTL3-14 inhibitors, half-maximal inhibitory concentration (IC50) and validated cancer types of METTL3/14 inhibitors. The effects of these small molecule inhibitors were derived from cellular assays, except for quercetin and eltrombopag for which no clinical trials have been reported. PC: pancreatic cancer, LC: lung cancer, PCa: Prostate cancer, CRC: Colorectal cancer, GBM: glioblastoma, OS: Osteosarcoma, AML: Acute myelocytic leukemia