Fig. 3
From: Methyltransferase-like proteins in cancer biology and potential therapeutic targeting
The mechanism of N6-methyladenosine (m6A) methylation. Introduction of the main members involved in m6A modifications. METT3 and METTL14 mainly catalyze the formation of m6A RNA modification; FTO and ALKBH5 are the major demethylating molecules; The m6A-modified RNA reader proteins include IGF2BP1/2/3, YTHDF1/2/3, YTHDC1/2/3, HuR, hnRNPA2BA, hnRNPC, eEFi, etc. M6A modification modulates RNA export, RNA decay, RNA splicing, miRNA processing, RNA stability, RNA translation