Table 1 METTL family members with known roles in cancer
From: Methyltransferase-like proteins in cancer biology and potential therapeutic targeting
METTL family member | Enzymatic function | Role | Substrates |
|---|---|---|---|
METTL1 | N7-methylguanine | Oncogene/tumor suppressor | miRNA, tRNA, mRNA |
METTL2A/B | N3-methylcytidine | Oncogene | tRNA |
METTL3/14 | N6-methyladenosine | Oncogene/tumor suppressor | mRNA, tRNA, pri-mRNA, lncRNA, snRNA, rRNA, miRNA |
METTL4 | N6-methyladenosine | Oncogene/tumor suppressor | mtDNA, miRNA, snRNA |
METTL5 | N6-methyladenosine | Oncogene | 18S rRNA |
METTL6 | N3-methylcytidine | Oncogene | tRNA |
METTL7A/B | N6-methyladenosine | Oncogene | LncRNA, mRNA |
METTL8 | N3-methylcytidine | Oncogene | mt-tRNA, mRNA |
METTL9 | Histidine methylation | Oncogene | HxH motif substrates |
METTL11A | N6-methyladenosine | Oncogene | RCC1, RB |
METTL12 | Lysine methylation | Unknown | Â |
METTL13 | eEF1A methylation | Unknown | Â |
METTL15 | N4-methylcytidine | Unknown | 12S RNA |
METTL16 | N6-methyladenosine | Oncogene | mRNA, lncRNA, snRNA U6 |
METTL17 | N5-methylcytosine N4-methylcytidine | Unknown | mt-rRNA |
METTL18 | Histidine methylation | Unknown | Â |
METTL20 | Lysine methylation | Unknown | Â |
METTL21A/C/D | Lysine methylation | Unknown | Â |
METTL21B | Lysine methylation | Tumor suppressor | Â |