Methyltransferase-like proteins in cancer biology and potential therapeutic targeting

Table 2 The role of METTL1 in various cancers

Role	Cancer	MTTL1 Targets	Downstream	Prognosis*	Mechanism	Cellular function	References
Oncogene	HCC	HDGF		Poor	m7G tRNAs	Proliferation	[74]
		TGF-β2	PMN-MDSCs	Poor	m7G tRNAs	Immunosuppressive microenvironment	[75]
		EGFR		Poor	m7G tRNAs	lenvatinib resistance	[250]
		DNA-PKcs or DNA ligase IV	NHEJ-mediated DNA DSB repair	Poor	m7G tRNAs	Radiotherapy resistance	[165]
		SLUG/SNAIL	DNA repair	Poor	m7G tRNAs	Metastasis	[166]
	NPC		WNT/β-catenin	Poor	m7G tRNAs	EMT, chemoresistance	[80]
	Lung cancer	Proliferation-associated mRNA		Poor	m7G tRNAs	Growth, migration, and invasion	[168]
	ICC	EGFR, cell cycle-associated mRNA		Poor	m7G tRNAs	Proliferation	[167]
	ICC	CXCL8	PMN-MDSCs	Poor	m7G tRNAs	Immunosuppressive	[232]
	Bladder cancer	EGFR/EFEMP1		Poor	m7G tRNAs	Proliferation, migration, and invasion	[76]
	ESCC	RPOTOR/ULK1		Poor	m7G tRNAs	Proliferation, autophagy	[78]
	ESCC	MTORC1	ULK1	Poor	m7G tRNAs	Autophagy	[79]
	GC	Cell cycle-associated mRNA	AKT/STAT3	Poor	m7G tRNAs	Proliferation	[81]

*Represents the correlation of a higher expression level of METTL1 with a good or poor prognosis

ISSN: 1756-8722