Methyltransferase-like proteins in cancer biology and potential therapeutic targeting

Qi, Ya-Nan; Liu, Zhu; Hong, Lian-Lian; Li, Pei; Ling, Zhi-Qiang

doi:10.1186/s13045-023-01477-7

Journal of Hematology & Oncology

Table 3 The role of METTL3 in various cancers

From: Methyltransferase-like proteins in cancer biology and potential therapeutic targeting

Role	Cancer	MTTL3 targets	Downstream	Prognosis*	Mechanism	Cellular function	References
Oncogene	Gastric cancer	HDGF	GLUT4, ENO2	Poor	RNA stability by IGF2BP3	Migration, proliferation	[139]
		ZMYM1	E-cadherin	Poor	RNA stability by HuR	EMT, migration	[169]
		SPHK2	KLF2	Poor	RNA translation by YTHDF1	Proliferation, migration, invasion	[170]
		PARP1		Poor	RNA stability by YTHDF1	Oxaliplatin resistance	[257]
		LncRNA THAP7-AS1	CUL4B	Poor	RNA stability by IGF2BP1	Growth, migration, and invasion	[171]
		NDUFA4		Poor	RNA stability by IGF2BP1	Proliferation, ROS, glycolysis	[218]
	Colorectal cancer	GLUT1	mTORC1	Poor	RNA translation	Proliferation	[219]
		GLUT1, HK2		Poor	RNA stability by IGF2BP2/3	Proliferation, glycolysis	[259]
		HIF-1α		Poor		Glycolysis	[220]
		Sox2	CCND1, MYC, POU5F1	Poor	RNA stability by IGF2BP1/2	Cell stemness, metastasis	[301]
		Sec62	Wnt/β-catenin		RNA stability by IGF2BP1	Cell stemness, chemoresistance	[302]
		CRB2	Hippo	Poor	RNA decay by YTHDF2	Proliferation, migration, invasion	[173]
		EphA2、VEGFA	PI3K/AKT/mTOR、EERK1/2	Poor	RNA stability by IGF2BP2/3	Proliferation, migration, invasion, VM	[85]
		LINC01559	miR-106b-5p/PTEN	Poor		Proliferation, metastasis	[174]
		pri-miR-196b	miR-196b	Poor		Metastasis	[175]
	Liver carcinoma	SOCS2		Poor	RNA decay by YTHDF2	Proliferation, migration	[177]
		YAP1	VE-cadherin, MMP2, MMP9	Poor		Vasculogenic mimicry	[178]
		ACLY, SCD1		Poor	RNA m6A modification by METTL14	Lipid metabolism	[215]
		Rubicon			RNA translation by YTHDF1	Autophagy	[216]
		FOXO3			RNA stability by YTHDF1	Autophagy, Chemoresistance	[251]
		SLC7A11			RNA stability by IGF2BP1	Ferroptosis resistance	[303]
		IFIT2		Poor	RNA decay by YTHDF2	Proliferation, invasion, apoptosis	[88]
		Pri-miR-589-5p	miR-589-5p	Poor		Malignant development	[86]
		HKDC1	JAK2/STAT1/caspase-3			progression	[304]
	Lung cancer	YAP		Poor	RNA translation by YTHDF1/3	Migration, chemoresistance	[102]
		circIGF2BP3	PKP3, OTUB1		RNA	Immune escape	[233]
		DAPK2	NF-κB	Poor	RNA decay by YTHDF2	Proliferation, migration	[181]
		SOX2				Proliferation, migration, invasion, DDP-resistance	[252]
		ENO1		Poor	RNA translation by YTHDF1	Warburg effect	[223]
		SLC7A11		Poor	RNA stability and translation by YTHDF1	Proliferation, inhibits ferroptosis	[196]
		LncRNA SNHG17	LATS2	Poor		Migration, invasion, EMT, resistance	[253]
	Prostate cancer	USP4	ARHGDIA	poor	RNA decay by YTHDF2、HNRNPD	Invasion, migration	[182]
	Prostate cancer	NKX3-1, LHPP		Poor	RNA decay by YTHDF2	Proliferation, migration	[183]
	Bladder cancer	PD-L1		Poor	RNA stability by IGF2BP1	Immune escape	[147]
		BIRC5		Poor	RNA stability by IGF2BP3	Proliferation, migration, invasion	[146]
		pri-miR221/222		Poor	Pri-mRNA maturation by DGCR8	Proliferation	[20]
	Breast cancer	EGF	RAD51	Poor	RNA translation by YTHDC1	Chemoresistance	[254]
		KRT7			RNA stability by IGF2BP1/HuR RNA translation by YTHDF1/eEF1	Migration	[186]
		PD-L1		Poor	RNA stability by IGF2BP3	Immune escape	[235]
		AK4	p38, ROS	Poor	RNA stability by ?	Apoptosis, chemoresistance	[255]
	Thyroid carcinoma	c-Rel	IL-8		RNA decay by YTHDF2	Proliferation	[106]
	Thyroid carcinoma	pri-miR-222-3p	STK4		promote pri-miRNA to mature	Proliferation, migration, invasion	[188]
	Chronic myeloid leukemia	PES1, MYC		Poor	RNA m6A modification by METTL14	Proliferation, imatinib resistant	[299]
	Glioblastoma	ADAR1	CDK2	Poor	RNA stability by YTHDF1	Proliferation	[110]
		LncRNA MALAT1	NF-κB	Poor	RNA stability by HuR	Proliferation, malignancy	[111]
		UBXN1	NF-κB	Poor	RNA decay by YTHDF2	Proliferation, migration	[189]
	Medulloblastoma	PTCH1, GLI2	Sonic hedgehog signaling	Poor		Proliferation	[190]
	Melanoma	EGFR	RAF/MEK/ERK	Poor	RNA translation by ?	Chemoresistance	[256]
	Melanoma	PD-L1, Stat1, Irf1			RNA decay by YTHDF2	IMMUNE escape	[236]
	Cervical cancer	HK2		Poor	RNA stability by YTHDF1	Proliferation, Warburg effect	[305]
		LncRNA FOXD2-AS1	p21			Proliferation, migration, apoptosis	[193]
		RAB2B		Poor	RNA stability by IGF2BP3	Proliferation	[192]
		TXNDC5	ER stress	Poor	YTHDF1/2、IGF2BP2/3	PROLIFERATION, migration	[93]
		CDC25B	CDK1/cyclinB	Poor	RNA stability by YTHDF1	Proliferation	[191]
		CTSL		Poor	RNA stability by IGF2BP2	Metastasis	[94]
	Ovarian cancer	pri-miRNA-1246	CCNG2	Poor	promote pri-miRNA to mature	Proliferation, metastasis	[195]
	Ovarian cancer	pri-miR-126-5p	PTEN, PI3K/Akt/mTOR		promote pri-miRNA to mature	Proliferation, migration, invasion	[194]
	Gallbladder cancer	DUSP5		Poor	RNA decay by YTHDF2	Proliferation, migration, invasion	[100]
	Esophageal squamous cell carcinoma	IFIT2		Poor		Proliferation, migration, invasion	[97]
	Renal cell carcinoma	ZNF667	CDKN3	Poor	RNA stability by IGF2BP2 RNA translation by YTHDF1	Proliferation	[197]
	Renal cell carcinoma	HHLA2		Poor		Proliferation, migration, invasion	[96]
	Multiple myeloma	pri-miR-27a-3p, YY1	miR-27a-3p	Poor		Proliferation, stemness, apoptosis	[89]
	Osteosarcoma	LncRNA DANCR		Poor		Proliferation, migration, invasion	[90]
Tumor suppressor	Colorectal cancer	KIF26B			RNA decay by YTHDF2	Inhibit proliferation, migration	[151]
	Lung adenocarcinoma	FBXW7			RNA translation by ?	Tumor progression	[306]
	Thyroid carcinoma	STEAP2	Hedgehog			EMT	[105]

*Represents the correlation of a higher expression level of METTL13 with a good or poor prognosis

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