Table 4 The role of METTL14 in various cancers
From: Methyltransferase-like proteins in cancer biology and potential therapeutic targeting
Role | Cancer | METTL14 target | Downstream | Prognosis* | Mechanism | Cellular function | References |
|---|---|---|---|---|---|---|---|
Oncogene | Pancreatic cancer | PERP | Poor | RNA decay by YTHDF2 | Proliferation, migration | [208] | |
Prostate cancer | THBS1 | Poor | RNA decay by YTHDF2 | Proliferation | [209] | ||
Hepatocellular carcinoma | HNF3γ | OATP1B1, OATP1B3 | Poor | RNA stability by IGF2BPs | Sorafenib resistance | [210] | |
Nedd4 | TGF-β, TGFBR1 | Growth, metastasis | [211] | ||||
ARHGAP5-AS1 | CSDE1, TRIM28 | RNA stability by IGF2BP2 | Invasion, metastasis | [307] | |||
Gastric cancer | LHPP | GSK3b, HIF1A | Growth, metastasis | [212] | |||
Breast cancer | E2F8 | RNA stability by YTHDF1 | Chemoresistance, DNA replication, DNA damage repair | [213] | |||
Head and neck squamous cell carcinoma | LNCAROD | YBX1, HSPA1A | Proliferation, mobility | [214] | |||
Bladder cancer | lncDBET | FABP5, PPAR | RNA decay by YTHDF2 | Proliferation, migration | [229] | ||
Tumor suppressor | Cholangiocarcinoma | MACF1 | loss-of-function mutation R298H in METTL14 | Proliferation, metastasis | [198] | ||
Siah2 | PD-L1 | RNA decay by YTHDF2 | Immunotherapy sensitivity | [249] | |||
Colorectal cancer | SOX4 | EMT, PI3K/AKT | Better | RNA decay by YTHDF2 | Migration, invasion and metastasis | [124] | |
XIST | Better | RNA decay by YTHDF2 | Growth, invasion, Metastasis | [123] | |||
KLF4 | Better | RNA stability by IGF2BP2 | Metastasis | [199] | |||
ARRDC4 | ZEB1 | Better | RNA decay by YTHDF2 | Metastasis | [155] | ||
Renal cell carcinoma | Pten | PI3K/AKT | Better | RNA stability by YTHDF1 | Proliferation, migration | [200] | |
ITGB4 | EMT, PI3K/AKT | Better | RNA decay by YTHDF2 | Migration, invasiveness, Metastasis | [201] | ||
BPTF | ENO2, SRC | Better | Metastasis | [230] | |||
Bladder cancer | USP38 | EMT | RNA decay by YTHDF2 | Migration, invasion | [202] | ||
Malfunction of the methyltransferase complex | Invasion, migration, apoptosis | [203] | |||||
Gastric cancer | circORC5 | miR-30c-2-3p/AKT1S1 | Better | Growth, invasion | [125] | ||
Esophageal squamous cell carcinoma | miR‐99a‐5p | TRIB2, HDAC2, Akt/mTOR/S6K1 | Radioresistance, cancer stem-like cells persistence | [205] | |||
Breast cancer | miR-375 | SOX12 | Proliferation, invasion | [161] | |||
Papillary thyroid cancer | OIP5-AS1 | EGFR, AKT, MEK/ERK | Proliferation, migration, invasion | [207] |