Fig. 9

Schematic diagram demonstrating the synergistic antitumor immune effect of Y332D plus PD-1 blockade. a Y332D restored the cytotoxic effects of TGF-β-suppressed CD8⁺ T cells and inhibited TGF-β-mediated collagen production in cancer-associated fibroblasts (CAF) cells. b Y332D promoted T cells infiltration through vascular normalization. c Y332D in combination with PD-1 blockade synergistically enhanced antitumor immunity