Table 1 Properties of CD20 × CD3 bispecific antibodies

Length

Full-length IgG1

Fully humanized

Full-length IgG1

Full-length IgG1

Configuration

Anti-CD20: anti-CD3 = 2:1

Anti-CD20: anti-CD3 = 1:1

Anti-CD20: anti-CD3 = 1:1

Fc mutation

PG LALA

N297

L234F, L235E, and D265A

Administration

IV

SC/IV

SC

Dosing

Step-wise

Step-wise

Step-wise

Depleting of B cells prior to bsAb

Yes

No

No

Combined with CD20 mAbs

Yes

No

Yes

References

[1, 4]

[5, 6]

[5, 9]