Table 1 Patients’ characteristics

Median age—years (range)

59 (21–80)

ECOG score—n (%)

 0

22 (71)

 1

9 (29)

Gender—n (%)

 Female

20 (65)

 Male

11 (35)

AML type—n (%)

 De novo

31 (100)

 Secondary

0 (0)

Prior treatment—n (%)

 3 + 7^‡

17 (55)

 3 + 7 + midostaurin^‡

3 (10)

 A-ICE^‡

6 (19)

 Other*

5 (16)

Mutations—n (%)

 FLT3-ITD

5 (15)

 FLT3-TKD

4 (13)

MRD Marker—n (%)

 NPM1

28 (90)

 IDH2

2 (6)

 RUNX1-RUNX1T1

1 (3)

 DTA mutations^a

0 (0)

MRD baseline values

 NPM1 MRD median (range) (qPCR)^⁑

936 (5—656,344)

 IDH2 MRD median (range) (NGS)^†

0.729 (0.2–1.258)

 RUNX1-RUNX1T1 MRD median (range) (NGS)^†

0.06 (n.a.)