Fig. 5

Lipid-targeted therapy in combination with chemotherapy, targeted therapy and immunotherapy. Lipid metabolism reprogramming within tumors not only propels tumor progression and drug resistance, but also play a crucial role in shaping the immunosuppressive microenvironment. This provides a theoretical foundation for the comprehensive treatment strategies by targeting tumor lipid metabolism. In numerous preclinical studies, inhibitors of lipid metabolism have shown significant anti-tumor effects in combination with chemotherapy, targeted therapy and immunotherapy, which is superior to a single-target treatment. The targets of these inhibitors primarily include lipid uptake (CD36, FABPs, FATPs), lipid synthesis (ACLY, ACCs, FASN, SCDs, SERBP, HMGCR, ChoK, COX), FAO (CPT1, PPAR), and lipid storage in LDs (DGAT, ACAT). These findings provide valuable insights for optimizing therapeutic strategy for cancer patients by combination lipid-targeted therapy with present anti-tumor therapy