Fig. 1
From: Genomic profiling of post-transplant lymphoproliferative disorders using cell-free DNA
Copy number aberrations found in cell-free DNA from PTLD patients. A Overview of copy number variations (CNVs) for individual PTLD patients, grouped by Epstein–Barr virus (EBV) status and sorted on fraction of genome altered (FGA). Chromosomal regions with gains are indicated in red and losses in blue. B A significant correlation between estimated tumor fraction (ETF) and lactate dehydrogenase (LDH) was observed. Dashed line represents cut-off value at 248 U/L discriminating clinically elevated LDH from normal LDH value. C Correlation between ETF and metabolic tumor volume (MTV). In panels B and C, the grey areas around the regression lines represent 95% CI and the Spearman coefficient is indicated with ρ. D FGA in PTLD patients categorized by Epstein–Barr virus (EBV) status, as determined by EBER-ISH, shows that EBV-negative patients have a higher FGA, although insignificant according to Wilcoxon Signed Rank test. Only PTLD samples with CNVs (FGA > 0) are shown in B–D