Fig. 6

Nb-TriTE treatment effectively inhibits the growth of PDX tumors. A Schematic experimental design of the PDX tumor model studies. Tumor growth (B), and survival curves (C) in PDX models (n = 5 per group) treated daily with either Nb-TriTE or Nb-BiTE for 6 consecutive days. D The dynamic changes in the proportion of T cells bound to Nb-TriTE within 72 h after treatment. E–G The levels of IL-2 (E), IFN-γ (F) and TNF-α (G) after treatment with the Nb-TriTE or Nb-BiTE. CD3⁺ CD8⁺ T cell infiltration in the tumor tissues and spleen based on flow cytometry analysis, representative flow cytometry density plots (H) and statistical bar chart (J, K). TUNEL and Ki67 staining of tumor tissues. Representative images (I) and statistical bar chart (L, M). TUNEL staining of tumor tissues. Scale bars, 125 μm; Ki67 IHC of tumor tissues. Scale bars, 100 μm. (n = 3 per group)