Skip to main content

Table 2 Multivariable analysis of progression rate of MGUS to MM

From: The Association of Agent Orange Exposure with the progression of monoclonal gammopathy of undetermined significance to multiple myeloma: a population-based study of Vietnam War Era Veterans

 Parameter

 

aHR

95% Confidence Interval

P-value

AO Exposure

    
 

None

 

(reference)

 
 

High

1.48

1.02–2.16

0.04

 

Medium

1.05

0.89–1.25

0.55

 

Low

0.83

0.50–1.40

0.49

Age at MGUS Diagnosis (year)

 

0.97

0.96–0.98

 < 0.0001

Gender

    
 

Female

 

(reference)

 
 

Male

0.84

0.51–1.37

0.49

Race

    
 

White

 

(reference)

 
 

Black

1.23

1.07–1.42

0.004

BMI Category

    
 

Obese

1.29

1.06–1.57

0.012

 

Overweight

1.24

1.01–1.51

0.041

 

Normal weight

 

(reference)

 
 

Underweight

0.58

0.26–1.31

0.19

M-spike (g/dL)

    
 

 ≥ 1.5

4.37

3.62–5.26

 < 0.0001

 

 < 1.5

 

(reference)

 

MGUS Type

    
 

IgA

1.53

1.28–1.83

 < 0.0001

 

IgG

 

(reference)

 

CCI

 

0.96

0.93–0.98

0.003

  1. A multivariable time-to-competing event analysis with death as a competing event was utilized (see Supplementary section)
  2. aHR multivariable-adjusted hazard ratio, IG immunoglobulin, BMI body mass index, M-spike monoclonal spike, CCI Charlson commorbidity index