Fig. 1
From: Vaccines: a promising therapy for myelodysplastic syndrome
Peptide vaccine targets for MDS. A WT-1 (Wilms tumor 1) peptide is a zinc finger transcription factor overexpressed in leukemic blasts in MDS and is associated with poor prognosis. B PR-1 is a human leukocyte HLA-A2 restricted peptide derived from the azurophil granule proteases neutrophil elastase (NE) and proteinase-3 (P3) and is highly expressed on myeloid blasts cells. C NY-ESO-1 is a cancer testis antigen (CTA) and its expression is upregulated on myeloid cells after treatment with hypomethylating agents (HMAs) such as decitabine