Fig. 4From: cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironmentcAMP signaling in immune cells. The GPCR-mediated cAMP signaling is involved in regulating the differentiation, exhaustion and cytotoxic activities of multiple types of immune cells. Both PKA and EPAC mediate the diverse effects of cAMP on immune cellsBack to article page