Fig. 2

Schematic overview of neoplasia-induced hepatic reprogramming. Top vessel provides a snapshot of homeostatic circulating glycoproteome. Mid vessel schematic depicts early hepatic reprogramming, including changes in glycosylation and abundance of circulating glycoproteins, of circulating liver-derived glycoproteome in pre-cancerous state. Bottom vessel depicts neoplasia-induced hepatic reprogramming with even further increase in glycosylation remodeling and abundance increase. At this stage tumor derived circulating DNA and circulating tumor cells can be detected in circulation