Table 2 Representative glycoproteins as cancer biomarkers
From: Decoding the glycoproteome: a new frontier for biomarker discovery in cancer
Marker | Full name | Cancer type | Cancer-associated glycoforms* | Refs. | |
|---|---|---|---|---|---|
AFP | α-Fetoprotein | Liver | Core-fucosylation (AFP-L3) |
| |
β-hCG | β-Human chorionic gonadotropin | Testicular, ovarian | Tri-antennary branching |
| |
MUC1 (CA15-3 /CA27-29) | Mucin1 (Cancer antigen 15–3/27–29) | Breast | Sialylation & High-mannose |
| |
CA19-9 | Carbohydrate antigen 19–9 or cancer antigen 19–9 | Pancreatic, ovarian, gastrointestinal | Sialyl Lewis-a |
| |
MUC16 (CA125) | Mucin16 (Cancer antigen 125) | Ovarian | Sialyl-Tn antigen |
| |
CEA and other CEACAMs | Carcinoembryonic antigen-related cell adhesion molecules | Colorectal, pancreatic, lung | Fucosylation & Bisection and branching |
| |
