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  1. Hypoxia, a common feature of the tumor microenvironment in various types of cancers, weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby reducing tumoral immunogenicity. Stu...

    Authors: Qinghua Wu, Li You, Eugenie Nepovimova, Zbynek Heger, Wenda Wu, Kamil Kuca and Vojtech Adam
    Citation: Journal of Hematology & Oncology 2022 15:77
    Content type: Review Published on:

  2. Urothelial carcinoma (UC) is the most common pathological type of bladder cancer, a malignant tumor. However, an integrated multi-omics analysis of the Chinese UC patient cohort is lacking.

    Authors: Ning Xu, Zhenmei Yao, Guoguo Shang, Dingwei Ye, Haixing Wang, Hailiang Zhang, Yuanyuan Qu, Fujiang Xu, Yunzhi Wang, Zhaoyu Qin, Jiajun Zhu, Fan Zhang, Jinwen Feng, Sha Tian, Yang Liu, Jianyuan Zhao…
    Citation: Journal of Hematology & Oncology 2022 15:76
    Content type: Research Published on:

  3. BH3-mimetics are a novel drug class of small molecule inhibitors of BCL2 family proteins which restore apoptosis in malignant cells. The only currently approved BH3-mimetic, the selective BCL2 inhibitor veneto...

    Authors: Thomas E. Lew and John F. Seymour
    Citation: Journal of Hematology & Oncology 2022 15:75
    Content type: Review Published on:

  4. Natural killer (NK)/T-cell lymphomas are aggressive malignancies with a predilection for Asian and South American populations. Epstein–Barr virus (EBV) infection in lymphoma cells is universal. Predominantly e...

    Authors: Eric Tse, Wei-Li Zhao, Jie Xiong and Yok-Lam Kwong
    Citation: Journal of Hematology & Oncology 2022 15:74
    Content type: Review Published on:

  5. Despite tremendous success of molecular targeted therapy together with immunotherapy, only a small subset of patients can benefit from them. Chemotherapy remains the mainstay treatment for most of tumors inclu...

    Authors: Yao Jiang, Wei Huang, Xiaojiao Sun, Xiaozhou Yang, Youming Wu, Jiaojiao Shi, Ji Zheng, Shujie Fan, Junya Liu, Jun Wang, Zhen Liang, Nan Yang, Zhenming Liu and Yanyong Liu
    Citation: Journal of Hematology & Oncology 2022 15:73
    Content type: Correspondence Published on:

  6. Ferroptosis, a novel non-apoptotic form of cell death, can induce tumor cell death and treatment resistance. Lipid metabolism is closely related to ferroptosis; however, the effect of mammary adipocytes on bre...

    Authors: Yizhao Xie, Biyun Wang, Yannan Zhao, Zhonghua Tao, Ye Wang, Guangliang Chen and Xichun Hu
    Citation: Journal of Hematology & Oncology 2022 15:72
    Content type: Correspondence Published on:

  7. Authors: Jadwiga Węcławek-Tompol, Zuzanna Zakrzewska, Olga Gryniewicz-Kwiatkowska, Filip Pierlejewski, Ewa Bień, Agnieszka Zaucha-Prażmo, Olga Zając-Spychała, Anna Szmydki-Baran, Agnieszka Mizia-Malarz, Wioletta Bal, Małgorzata Sawicka-Żukowska, Agnieszka Kruk, Tomasz Ociepa, Anna Raciborska, Agnieszka Książek, Tomasz Szczepański…
    Citation: Journal of Hematology & Oncology 2022 15:71
    Content type: Correction Published on:

    The original article was published in Journal of Hematology & Oncology 2021 14:163

  8. Advanced pancreatic ductal adenocarcinoma (PDAC) is usually an incurable malignancy that needs newer therapeutic targets. Interleukin-1 receptor accessory protein (IL1RAP) is an innate immune mediator that reg...

    Authors: Yang Zhang, Xiaoyi Chen, Huamin Wang, Shanisha Gordon-Mitchell, Srabani Sahu, Tushar D. Bhagat, Gaurav Choudhary, Srinivas Aluri, Kith Pradhan, Plabani Sahu, Milagros Carbajal, Hui Zhang, Beamon Agarwal, Aditi Shastri, Robert Martell, Daniel Starczynowski…
    Citation: Journal of Hematology & Oncology 2022 15:70
    Content type: Letter to the Editor Published on:

    The Correction to this article has been published in Journal of Hematology & Oncology 2022 15:100

  9. International clinical practice guidelines have progressively endorsed direct oral anticoagulants (DOACs) as an alternative to low-molecular-weight heparins (LMWHs) monotherapy for the initial and long-term tr...

    Authors: Corinne Frere, Dominique Farge, Deborah Schrag, Pedro H. Prata and Jean M. Connors
    Citation: Journal of Hematology & Oncology 2022 15:69
    Content type: Correspondence Published on:

  10. Although chimeric antigen receptor (CAR)-modified adoptive T cell therapy is a promising immunotherapy for hematological malignancies, the efficacy improvement in relapsed/refractory acute lymphoblastic leukem...

    Authors: Peilong Lai, Xiaomei Chen, Yulian Wang, Jinghua Wang, Yuchen Zhang, Suxia Geng, Peng Li, Xin Du, Jianyu Weng and Duanqing Pei
    Citation: Journal of Hematology & Oncology 2022 15:68
    Content type: Correspondence Published on:

  11. Although messenger RNA (mRNA) vaccines have established efficacy for prevention of severe SARS-CoV2 infection in the general population, their effectiveness in patients with malignancy, especially those on ant...

    Authors: Anthony Rooney, Cory Bivona, Ben Liu, David Streeter, Han Gong and Qamar Khan
    Citation: Journal of Hematology & Oncology 2022 15:67
    Content type: Letter to the Editor Published on:

  12. The World Health Organization has defined a list of adverse events of special interest (AESI) for safety surveillance of vaccines. AESI have not been adequately assessed following COVID-19 vaccination in patie...

    Authors: Wei Kang, Jessica J. P. Shami, Vincent K. C. Yan, Xuxiao Ye, Joseph E. Blais, Xue Li, Victor H. F. Lee, Celine S. L. Chui, Francisco T. T. Lai, Eric Y. F. Wan, Carlos K. H. Wong, Ian C. K. Wong and Esther W. Chan
    Citation: Journal of Hematology & Oncology 2022 15:66
    Content type: Brief Report Published on:

  13. Conditioning of the bone marrow prior to haematopoietic stem cell transplant is essential in eradicating the primary cause of disease, facilitating donor cell engraftment and avoiding transplant rejection via ...

    Authors: James M. Griffin, Fiona M. Healy, Lekh N. Dahal, Yngvar Floisand and John F. Woolley
    Citation: Journal of Hematology & Oncology 2022 15:65
    Content type: Review Published on:

  14. Despite the increased usage of post-transplant cyclophosphamide (PTCy) in allogeneic hematopoietic stem cell transplantation (allo-HSCT), our knowledge of immune reconstitution post-allo-HSCT in the setting of...

    Authors: Chenchen Zhao, Matthew Bartock, Bei Jia, Neal Shah, David F. Claxton, Baldeep Wirk, Kevin L. Rakszawski, Myles S. Nickolich, Seema G. Naik, Witold B. Rybka, W Christopher C. Ehmann, Raymond J. Hohl, Jessica Valentin, Michelle Bernas-Peterson, Emily M. Gerber, Michele Zimmerman…
    Citation: Journal of Hematology & Oncology 2022 15:64
    Content type: Correspondence Published on:

  15. N7-methylguanosine (m7G), one of the most prevalent RNA modifications, has recently attracted significant attention. The m7G modification actively participates in biological and pathological functions by affecti....

    Authors: Yuejun Luo, Yuxin Yao, Peng Wu, Xiaohui Zi, Nan Sun and Jie He
    Citation: Journal of Hematology & Oncology 2022 15:63
    Content type: Review Published on:

  16. Neoadjuvant immunotherapy is emerging as novel effective intervention in lung cancer, but study to unearth effective surrogates indicating its therapeutic outcomes is limited. We investigated the genetic chang...

    Authors: Zhen Zhou, Zhengping Ding, Jie Yuan, Shengping Shen, Hong Jian, Qiang Tan, Yunhai Yang, Zhiwei Chen, Qingquan Luo, Xinghua Cheng, Yongfeng Yu, Xiaomin Niu, Liqiang Qian, Xiaoke Chen, Linping Gu, Ruijun Liu…
    Citation: Journal of Hematology & Oncology 2022 15:62
    Content type: Correspondence Published on:

  18. Extramedullary manifestations (EM) are rare in acute myeloid leukemia (AML) and their impact on clinical outcomes is controversially discussed.

    Authors: Jan-Niklas Eckardt, Friedrich Stölzel, Desiree Kunadt, Christoph Röllig, Sebastian Stasik, Lisa Wagenführ, Korinna Jöhrens, Friederike Kuithan, Alwin Krämer, Sebastian Scholl, Andreas Hochhaus, Martina Crysandt, Tim H. Brümmendorf, Ralph Naumann, Björn Steffen, Volker Kunzmann…
    Citation: Journal of Hematology & Oncology 2022 15:60
    Content type: Research Published on:

  19. Single-cell sequencing (SCS) is an emerging high-throughput technology that can be used to study the genomics, transcriptomics, and epigenetics at a single cell level. SCS is widely used in the diagnosis and t...

    Authors: Yingying Han, Dan Wang, Lushan Peng, Tao Huang, Xiaoyun He, Junpu Wang and Chunlin Ou
    Citation: Journal of Hematology & Oncology 2022 15:59
    Content type: Review Published on:

  21. Hodgkin lymphoma is a lymphatic malignancy commonly found in cervical lymph nodes. This study evaluated the worldwide incidence, mortality, associated risk factors, and temporal trends of Hodgkin lymphoma by s...

    Authors: Junjie Huang, Wing Sze Pang, Veeleah Lok, Lin Zhang, Don Eliseo Lucero-Prisno III, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers and Martin C. S. Wong
    Citation: Journal of Hematology & Oncology 2022 15:57
    Content type: Research Published on:

  22. Pevonedistat, the first small-molecule inhibitor of NEDD8-activating enzyme, has demonstrated clinical activity in Western patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). We rep...

    Authors: Hiroshi Handa, June-Won Cheong, Yasushi Onishi, Hiroatsu Iida, Yukio Kobayashi, Hyeoung-Joon Kim, Tzeon-Jye Chiou, Koji Izutsu, Olga Tsukurov, Xiaofei Zhou, Helene Faessel, Ying Yuan, Farhad Sedarati, Douglas V. Faller, Akiko Kimura and Shang-Ju Wu
    Citation: Journal of Hematology & Oncology 2022 15:56
    Content type: Letter to the Editor Published on:

  23. Lysophosphatidic acid (LPA) is a naturally occurring phospholipid that regulates cell proliferation, survival, and migration. However, its role on human multiple myeloma (MM) cells is largely unknown. In this ...

    Authors: Pan Su, Liuling Xiao, Lingqun Ye, Zhuo Wang, Wei Xiong, Qiang Wang, Xingzhe Ma, Miao Xian, Maojie Yang, Youli Zu, Sai Ravi Pingali, Jianfei Qian and Qing Yi
    Citation: Journal of Hematology & Oncology 2022 15:55
    Content type: Correspondence Published on:

  24. The clinical efficacy of SARS-CoV-2 vaccines according to antibody response in immunosuppressed patients such as hematological patients has not yet been established.

    Authors: José Luis Piñana, Lucia López-Corral, Rodrigo Martino, Lourdes Vazquez, Ariadna Pérez, Gabriel Martin-Martin, Beatriz Gago, Gabriela Sanz-Linares, Andrés Sanchez-Salinas, Lucia Villalon, Venancio Conesa-Garcia, María T. Olave, Magdalena Corona, Sara Marcos-Corrales, Mar Tormo, José Ángel Hernández-Rivas…
    Citation: Journal of Hematology & Oncology 2022 15:54
    Content type: Research Published on:

  25. Transfer RNA-derived fragments (tRFs) are a new class of small non-coding RNAs. Recent studies suggest that tRFs participate in some pathological processes. However, the biological functions and mechanisms of ...

    Authors: Wenhan Yang, Kaiping Gao, Youhui Qian, Yongyi Huang, Qin Xiang, Cheng Chen, Qianqian Chen, Yiling Wang, Fuyuan Fang, Qihan He, Siqi Chen, Juan Xiong, Yangchao Chen, Ni Xie, Duo Zheng and Rihong Zhai
    Citation: Journal of Hematology & Oncology 2022 15:53
    Content type: Research Published on:

  26. LncRNA-PACERR plays critical role in the polarization of tissue-associated macrophages (TAMs). In this study, we found the function and molecular mechanism of PACERR in TAMs to regulate pancreatic ductal adeno...

    Authors: Yihao Liu, Minmin Shi, Xingfeng He, Yizhi Cao, Pengyi Liu, Fanlu Li, Siyi Zou, Chenlei Wen, Qian Zhan, Zhiwei Xu, Jiancheng Wang, Baofa Sun and Baiyong Shen
    Citation: Journal of Hematology & Oncology 2022 15:52
    Content type: Research Published on:

  27. Acute myeloid leukemia (AML) is a severe hematologic malignancy prevalent in older patients, and the identification of potential therapeutic targets for AML is problematic. Autophagy is a lysosome-dependent ca...

    Authors: Wonhyoung Seo, Prashanta Silwal, Ik-Chan Song and Eun-Kyeong Jo
    Citation: Journal of Hematology & Oncology 2022 15:51
    Content type: Review Published on:

  28. Authors: Sepideh Mirzaei, Mohammad Hossein Gholami, Kiavash Hushmandi, Farid Hashemi, Amirhossein Zabolian, Israel Canadas, Ali Zarrabi, Noushin Nabavi, Amir Reza Aref, Francesco Crea, Yuzhuo Wang, Milad Ashrafizadeh and Alan Prem Kumar
    Citation: Journal of Hematology & Oncology 2022 15:50
    Content type: Correction Published on:

    The original article was published in Journal of Hematology & Oncology 2022 15:18

  29. Chromatin has distinct three-dimensional (3D) architectures important in key biological processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn, aberrant 3D structure...

    Authors: Siwei Deng, Yuliang Feng and Siim Pauklin
    Citation: Journal of Hematology & Oncology 2022 15:49
    Content type: Review Published on:

  30. Multiparametric magnetic resonance imaging (mpMRI) is an emerging standard for diagnosing and prognosing prostate cancer, but ~ 20% of clinically significant tumors are invisible to mpMRI, as defined by the Pr...

    Authors: Amanda Khoo, Lydia Y. Liu, Taylor Y. Sadun, Amirali Salmasi, Aydin Pooli, Ely Felker, Kathleen E. Houlahan, Vladimir Ignatchenko, Steven S. Raman, Anthony E. Sisk Jr., Robert E. Reiter, Paul C. Boutros and Thomas Kislinger
    Citation: Journal of Hematology & Oncology 2022 15:48
    Content type: Letter to the Editor Published on:

  31. The gut microbiota have long been recognized to play a key role in human health and disease. Currently, several lines of evidence from preclinical to clinical research have gradually established that the gut m...

    Authors: Yuting Lu, Xiangliang Yuan, Miao Wang, Zhihao He, Hongzhong Li, Ji Wang and Qin Li
    Citation: Journal of Hematology & Oncology 2022 15:47
    Content type: Review Published on:

  32. Personalized immunotherapy utilizing cancer vaccines tailored to the tumors of individual patients holds promise for tumors with high genetic heterogeneity, potentially enabling eradication of the tumor in its...

    Authors: Bingfeng Zuo, Yang Zhang, Kangjie Zhao, Li Wu, Han Qi, Rong Yang, Xianjun Gao, Mengyuan Geng, Yingjie Wu, Renwei Jing, Qibing Zhou, Yiqi Seow and HaiFang Yin
    Citation: Journal of Hematology & Oncology 2022 15:46
    Content type: Research Published on:

  33. Targeting nucleotide metabolism can not only inhibit tumor initiation and progression but also exert serious side effects. With in-depth studies of nucleotide metabolism, our understanding of nucleotide metabo...

    Authors: Huai-liang Wu, Yue Gong, Peng Ji, Yi-fan Xie, Yi-Zhou Jiang and Guang-yu Liu
    Citation: Journal of Hematology & Oncology 2022 15:45
    Content type: Review Published on:

  34. Triple-negative breast cancer (TNBC) is a subtype of human breast cancer with one of the worst prognoses, with no targeted therapeutic strategies currently available. Regulated cell death (RCD), also known as ...

    Authors: Minru Liao, Rui Qin, Wei Huang, Hong-Ping Zhu, Fu Peng, Bo Han and Bo Liu
    Citation: Journal of Hematology & Oncology 2022 15:44
    Content type: Review Published on:

  36. Inevitable relapses remain as the major therapeutic challenge in patients with mantle cell lymphoma (MCL) despite FDA approval of multiple targeted therapies and immunotherapies. Fc gamma receptors (FcγRs) pla...

    Authors: Vivian Changying Jiang, Yang Liu, Alexa Jordan, Angela Leeming, Joseph McIntosh, Shengjian Huang, Rongjia Zhang, Qingsong Cai, Zhihong Chen, Yijing Li, Yuxuan Che, Lei Nie, Ingrid Karlsson, Linda Mårtensson, Mathilda Kovacek, Ingrid Teige…
    Citation: Journal of Hematology & Oncology 2022 15:42
    Content type: Letter to the Editor Published on:

  37. Chromosome translocations involving mixed lineage leukemia 1 (MLL1) cause acute leukemia in most infants and 5–10% children/adults with dismal clinical outcomes. Most frequent MLL1-fusion partners AF4/AFF4, AF...

    Authors: Xin Li, Yuan Yao, Fangrui Wu and Yongcheng Song
    Citation: Journal of Hematology & Oncology 2022 15:41
    Content type: Research Published on:

  38. Management of cancer-associated venous thromboembolism (VTE) is essential in treatment selection and cancer prognosis. However, to date, there is no method to assess the risk of VTE specifically associated wit...

    Authors: Yukari Tsubata, Takamasa Hotta, Kosuke Hamai, Naoki Furuya, Toshihide Yokoyama, Ryota Saito, Atsushi Nakamura, Takeshi Masuda, Megumi Hamaguchi, Shoichi Kuyama, Ryoichi Honda, Tadashi Senoo, Masamoto Nakanishi, Masahiro Yamasaki, Nobuhisa Ishikawa, Kazunori Fujitaka…
    Citation: Journal of Hematology & Oncology 2022 15:40
    Content type: Letter to the Editor Published on:

  39. Persistence of CAR-T cell function is associated with relapse rate after CAR-T therapy, while co-stimulatory agents are highly concerned with the persistence of CAR-T cells. In this study, we designed and cons...

    Authors: Jingwen Tan, Yujie Jia, Meixia Zhou, Chengcheng Fu, Israth Jahan Tuhin, Jing Ye, Masuma Akter Monty, Nan Xu, Liqing Kang, Minghao Li, Jiaqi Shao, Xiaoyan Fang, Hongjia Zhu, Lingzhi Yan, Changju Qu, Shengli Xue…
    Citation: Journal of Hematology & Oncology 2022 15:39
    Content type: Letter to the Editor Published on:

  41. Immunotherapy has demonstrated a limited clinical efficacy in approximately 5% of cholangiocarcinoma. The main challenges for an effective immunotherapy response in cholangiocarcinoma arise from the tumor micr...

    Authors: Tao Xia, Keyu Li, Nan Niu, Yingkuan Shao, Ding Ding, Dwayne L. Thomas, Hao Jing, Kenji Fujiwara, Haijie Hu, Arsen Osipov, Chunhui Yuan, Christopher L. Wolfgang, Elizabeth D. Thompson, Robert A. Anders, Jin He, Yiping Mou…
    Citation: Journal of Hematology & Oncology 2022 15:37
    Content type: Research Published on:

  42. F-18 fluorodeoxyglucose positron emission tomography computed tomography (PET/CT) is used to assess response of non-Hodgkin lymphoma (NHL) to chimeric antigen receptor T cell (CAR-T) therapy. We sought to desc...

    Authors: William G. Breen, Matthew A. Hathcock, Jason R. Young, Roman O. Kowalchuk, Radhika Bansal, Arushi Khurana, N. Nora Bennani, Jonas Paludo, Jose C. Villasboas Bisneto, Yucai Wang, Stephen M. Ansell, Jennifer L. Peterson, Patrick B. Johnston, Scott C. Lester and Yi Lin
    Citation: Journal of Hematology & Oncology 2022 15:36
    Content type: Correspondence Published on:

  44. Cancer microenvironment is critical for tumorigenesis and cancer progression. The extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells proliferation, migration, invasion, a...

    Authors: Yangfu Jiang, Hongying Zhang, Jiao Wang, Yongliang Liu, Ting Luo and Hui Hua
    Citation: Journal of Hematology & Oncology 2022 15:34
    Content type: Review Published on:

  45. Authors: James L. Januzzi, Joseph M. Garasic, Scott E. Kasner, Vickie McDonald, Mark C. Petrie, Jonathan Seltzer, Michael Mauro, Kevin Croce, Ellin Berman, Michael Deininger, Andreas Hochhaus, Javier Pinilla-Ibarz, Franck Nicolini, Dong-Wook Kim, Daniel J. DeAngelo, Hagop Kantarjian…
    Citation: Journal of Hematology & Oncology 2022 15:33
    Content type: Correction Published on:

    The original article was published in Journal of Hematology & Oncology 2022 15:1

  46. Hepatocellular carcinoma (HCC) is well-known to be a highly prevalent malignant tumor, but the treatment of this pathological state has been still challenging. Solamargine (SM), a traditional Chinese herb-deri...

    Authors: Shuangshuang Yin, Wenke Jin, Yuling Qiu, Leilei Fu, Tao Wang and Haiyang Yu
    Citation: Journal of Hematology & Oncology 2022 15:32
    Content type: Letter to the Editor Published on:

  47. Natural killer (NK) cells are the predominant innate lymphoid cells that mediate anti-viral and anti-tumor immunity. NK cells arise from hematopoietic stem cells in the bone marrow (BM) and undergo lineage spe...

    Authors: Shoubao Ma, Michael A. Caligiuri and Jianhua Yu
    Citation: Journal of Hematology & Oncology 2022 15:31
    Content type: Letter to the Editor Published on:

  48. Isocitrate dehydrogenase-2 (IDH2) is a mitochondrial enzyme that catalyzes the metabolic conversion between isocitrate and alpha-ketoglutarate (α-KG) in the TCA cycle. IDH2 mutation is an oncogenic event in ac...

    Authors: Peiting Zeng, Wenhua Lu, Jingyu Tian, Shuang Qiao, Jiangjiang Li, Christophe Glorieux, Shijun Wen, Hui Zhang, Yiqing Li and Peng Huang
    Citation: Journal of Hematology & Oncology 2022 15:30
    Content type: Research Published on:

  49. Chimeric antigen receptor (CAR)-T cell therapy has demonstrated remarkable success in the treatment of hematologic malignancies, while the success has not yet been replicated in solid tumors. To some extent, t...

    Authors: Zhichen Sun, Rutian Li, Yun Shen, Siyi Tan, Naiqing Ding, Ruihan Xu, Xinyue Wang, Jia Wei, Baorui Liu and Fanyan Meng
    Citation: Journal of Hematology & Oncology 2022 15:29
    Content type: Rapid communication Published on:

  50. Hematopoietic stem cell transplant (HSCT) recipients are at high-risk for severe COVID-19 and have altered immune responses to vaccination. We sought to evaluate the dynamics of immune response to BNT162b2 mRN...

    Authors: Mathieu Leclerc, Rabah Redjoul, Anne Le Bouter, Florence Beckerich, Christine Robin, Vincent Parinet, Cécile Pautas, Dehbia Menouche, Selwa Bouledroua, Lydia Roy, Ludovic Cabanne, Yakout Nait-Sidenas, Slim Fourati and Sébastien Maury
    Citation: Journal of Hematology & Oncology 2022 15:27
    Content type: Rapid communication Published on:
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Journal of Hematology & Oncology

ISSN: 1756-8722

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