Dasatinib preferentially induces apoptosis by inhibiting Lyn kinase in nilotinib-resistant chronic myeloid leukemia cell line
© Okabe et al; licensee BioMed Central Ltd. 2011
Received: 29 June 2011
Accepted: 2 August 2011
Published: 2 August 2011
Nilotinib is approved for treatment of newly diagnosed chronic myeloid leukemia (CML) and it is shown superiority over imatinib in first-line treatment for patients of CML. In this study, we established a nilotinib-resistant cell line, K562NR, and evaluated the resistance to nilotinib and efficacy of dasatinib. We found activation of Lyn plays a dominant role in survival of the nilotinib-resistant cell line. We found dasatinib induces the apoptosis of nilotinib-resistant cells and inhibits Lyn kinase activity. This novel nilotinib-resistant CML cell line may help to explore novel therapy for CML.
To the editor
Conflicts of interests
The authors declare that they have no competing interests.
List of abbreviations
chronic myeloid leukemia
evaluating nilotinib efficacy and safety in clinical trials-newly diagnosed CML
fluorescence in situ hybridization
dasatinib versus imatinib study in treatment-naïve CML patients
We thank Novartis and Bristol-Myers Squibb for providing the compound. This work was supported by a "High-Tech Research Center" Project for private universities: matching fund subsidy from the MEXT (Ministry of Education, Culture, Sports, Science and Technology), and by the "University-Industry Joint Research Project" for private universities: matching fund subsidy from the MEXT. This work was also supported by Grants-in-Aid for Scientific Research from the MEXT.
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