Table 4 Overall Response Rate in IPASS Study, based on EGFR mutation, copy, and expression
ORR % | Gefitinib | Carboplatin+Paclitaxel | HR (95% CI) | P Value |
|---|---|---|---|---|
EGFR mutation | 71.2 | 47.3 | 2.75 (1.65-4.60) | 0.0001 |
No EGFR mutation | 1.1 | 23.5 | 0.04 (0.01-0.27) | 0.0013 |
High EGFR copy number | 58.9 | 44.8 | 1.79 (1.08-2.96) | .0243 |
Low EGFR copy number | 22.2 | 26.3 | 0.80 (0.38-1.68) | 0.5580 |
EGFR protein expression | 51.5 | 41.8 | 1.49 (0.92-2.42) | 0.1093 |
No EGFR protein Expression | 34.0 | 26.1 | 1.44 (0.60-3.47) | 0.4146 |