Nicolson M, Gilligan D, Smith I, Groen H, Manegold C, van Meerbeeck J, Hopwood P, Nankivell M, Pugh C, Stephens RJ: Pre-operative chemotherapy in patients with resectable non-small cell lung cancer (NSCLC): First results of the MRC LU22/NVALT/EORTC 08012 multi-centre randomised trial. J Clin Oncol (Meeting Abstracts). 2007, 25 (18_suppl): 7518-
Google Scholar
Scagliotti GV, Pastorino U, Vansteenkiste JF, Spaggiari L, Facciolo F, Orlowski T, Maiorino A, Hetzel M, Visseren-Grul C, Torri V: A phase III randomized study of surgery alone or surgery plus preoperative gemcitabine-cisplatin in early-stage non-small cell lung cancer (NSCLC): Follow-up data of Ch.E.S. J Clin Oncol (Meeting Abstracts). 2008, 26 (15_suppl): 7508-
Google Scholar
Pignon JP, Tribodet H, Scagliotti GV, Douillard JY, Shepherd FA, Stephens RJ, Dunant A, Torri V, Rosell R, Seymour L: Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group. J Clin Oncol. 2008, 26 (21): 3552-3559. 10.1200/JCO.2007.13.9030.
Article
PubMed
Google Scholar
Lim E, Harris G, Patel A, Adachi I, Edmonds L, Song F: Preoperative versus postoperative chemotherapy in patients with resectable non-small cell lung cancer: Systematic review and indirect comparison meta-analysis of randomized trials. J Clin Oncol (Meeting Abstracts). 2008, 26 (15_suppl): 7546-
Google Scholar
Felip E, Massuti B, Alonso G, González-Larriba JL, Camps C, Isla D, Costas E, Sánchez JJ, Griesinger F, Rosell R: Surgery (S) alone, preoperative (preop) paclitaxel/carboplatin (PC) chemotherapy followed by S, or S followed by adjuvant (adj) PC chemotherapy in early-stage non-small cell lung cancer (NSCLC): Results of the NATCH multicenter, randomized phase III trial. J Clin Oncol (Meeting Abstracts). 2009, 27 (15S): 7500-
Google Scholar
Strauss GM, Herndon JE, Maddaus MA, Johnstone DW, Johnson EA, Harpole DH, Gillenwater HH, Watson DM, Sugarbaker DJ, Schilsky RL: Adjuvant Paclitaxel Plus Carboplatin Compared With Observation in Stage IB Non-Small-Cell Lung Cancer: CALGB 9633 With the Cancer and Leukemia Group B, Radiation Therapy Oncology Group, and North Central Cancer Treatment Group Study Groups. J Clin Oncol. 2008, 26 (31): 5043-5051. 10.1200/JCO.2008.16.4855.
Article
PubMed Central
CAS
PubMed
Google Scholar
Pisters K, Vallieres E, Bunn PA, Crowley J, Chansky K, Ginsberg R, Gandara DR, Southwest Oncology G: S9900: Surgery alone or surgery plus induction (ind) paclitaxel/carboplatin (PC) chemotherapy in early stage non-small cell lung cancer (NSCLC): Follow-up on a phase III trial. J Clin Oncol (Meeting Abstracts). 2007, 25 (18_suppl): 7520-
Google Scholar
Vincent MD, Butts C, Seymour L, Ding K, Graham B, Twumasi-Ankrah P, Gandara D, Schiller J, Green M, Shepherd F: Updated survival analysis of JBR.10: A randomized phase III trial of vinorelbine/cisplatin versus observation in completely resected stage IB and II non-small cell lung cancer (NSCLC). J Clin Oncol (Meeting Abstracts). 2009, 27 (15S): 7501-
Google Scholar
Arriagada R, Dunant A, Pignon JP, Bergman B, Chabowski M, Grunenwald D, Kozlowski M, Le Pechoux C, Pirker R, Pinel MI: Long-term results of the international adjuvant lung cancer trial evaluating adjuvant Cisplatin-based chemotherapy in resected lung cancer. J Clin Oncol. 28 (1): 35-42. 10.1200/JCO.2009.23.2272.
Socinski MA, Stinchcombe TE: Duration of first-line chemotherapy in advanced non small-cell lung cancer: less is more in the era of effective subsequent therapies. J Clin Oncol. 2007, 25 (33): 5155-5157. 10.1200/JCO.2007.13.4015.
Article
CAS
PubMed
Google Scholar
Grossi F, Aita M, Follador A, Defferrari C, Brianti A, Sinaccio G, Belvedere O: Sequential, alternating, and maintenance/consolidation chemotherapy in advanced non-small cell lung cancer: a review of the literature. Oncologist. 2007, 12 (4): 451-464. 10.1634/theoncologist.12-4-451.
Article
CAS
PubMed
Google Scholar
Belani CP, Brodowicz T, Ciuleanu T, Kim JH, Krzakowski M, Laack E, Wu YL, Peterson P, Krejcy K, Zielinski C: Maintenance pemetrexed (Pem) plus best supportive care (BSC) versus placebo (Plac) plus BSC: A randomized phase III study in advanced non-small cell lung cancer (NSCLC). J Clin Oncol (Meeting Abstracts). 2009, 27 (18S): CRA8000-
Google Scholar
Franklin WA, Veve R, Hirsch FR, Helfrich BA, Bunn PA: Epidermal growth factor receptor family in lung cancer and premalignancy. Semin Oncol. 2002, 29 (1 Suppl 4): 3-14. 10.1053/sonc.2002.31520.
Article
CAS
PubMed
Google Scholar
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, Tan EH, Hirsh V, Thongprasert S, Campos D, Maoleekoonpiroj S, Smylie M, Martins R: Erlotinib in Previously Treated Non-Small-Cell Lung Cancer. N Engl J Med. 2005, 353 (2): 123-132. 10.1056/NEJMoa050753.
Article
CAS
PubMed
Google Scholar
Herbst RS, Prager D, Hermann R, Fehrenbacher L, Johnson BE, Sandler A, Kris MG, Tran HT, Klein P, Li X: TRIBUTE: A Phase III Trial of Erlotinib Hydrochloride (OSI-774) Combined With Carboplatin and Paclitaxel Chemotherapy in Advanced Non-Small-Cell Lung Cancer. J Clin Oncol. 2005, 23 (25): 5892-5899. 10.1200/JCO.2005.02.840.
Article
CAS
PubMed
Google Scholar
Gatzemeier U, Pluzanska A, Szczesna A, Kaukel E, Roubec J, De Rosa F, Milanowski J, Karnicka-Mlodkowski H, Pesek M, Serwatowski P: Phase III Study of Erlotinib in Combination With Cisplatin and Gemcitabine in Advanced Non-Small-Cell Lung Cancer: The Tarceva Lung Cancer Investigation Trial. J Clin Oncol. 2007, 25 (12): 1545-1552. 10.1200/JCO.2005.05.1474.
Article
CAS
PubMed
Google Scholar
Cappuzzo F, Ciuleanu T, Stelmakh L, Cicenas S, Szczesna A, Juhasz E, Esteban Gonzalez E, Molinier O, Klingelschmitt G, Giaccone G: SATURN: A double-blind, randomized, phase III study of maintenance erlotinib versus placebo following nonprogression with first-line platinum-based chemotherapy in patients with advanced NSCLC. J Clin Oncol (Meeting Abstracts). 2009, 27 (15S): 8001-
Google Scholar
Brugger W, Triller N, Blasinska-Morawiec M, Curescu S, Sakalauskas R, Manikhas G, Mazieres J, Whittom R, Rohr K, Cappuzzo F: Biomarker analyses from the phase III placebo-controlled SATURN study of maintenance erlotinib following first-line chemotherapy for advanced NSCLC. J Clin Oncol (Meeting Abstracts). 2009, 27 (15S): 8020-
Google Scholar
Lee JS, Ignacio J, Yu C, Zhou C, Wu Y, Chen Y, Zhang L, Jin K, Johnston M, Mok TS: FAST-ACT: A phase II randomized double-blind trial of sequential erlotinib and chemotherapy as first-line treatment in patients (pts) with stage IIIB/IV non-small cell lung cancer (NSCLC). J Clin Oncol (Meeting Abstracts). 2008, 26 (15_suppl): 8031-
Google Scholar
Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A, Lilenbaum R, Johnson DH: Paclitaxel-Carboplatin Alone or with Bevacizumab for Non-Small-Cell Lung Cancer. N Engl J Med. 2006, 355 (24): 2542-2550. 10.1056/NEJMoa061884.
Article
CAS
PubMed
Google Scholar
Herbst RS, O'Neill VJ, Fehrenbacher L, Belani CP, Bonomi PD, Hart L, Melnyk O, Ramies D, Lin M, Sandler A: Phase II Study of Efficacy and Safety of Bevacizumab in Combination With Chemotherapy or Erlotinib Compared With Chemotherapy Alone for Treatment of Recurrent or Refractory Non Small-Cell Lung Cancer. J Clin Oncol. 2007, 25 (30): 4743-4750. 10.1200/JCO.2007.12.3026.
Article
CAS
PubMed
Google Scholar
Hainsworth J, Herbst R: A phase III, multicenter, placebo-controlled, double-blind, randomized, clinical trial to evaluate the efficacy of bevacizumab in combination with erlotinib compared with erlotinib alone for treatment of advanced non-small cell lung cancer after failure of standard first line chemotherapy (BETA). Journal of Thoracic Oncology. 2008, 3 (11): S302-
Google Scholar
Miller VA, O'Connor P, Soh C, Kabbinavar F, for the AI: A randomized, double-blind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC). J Clin Oncol (Meeting Abstracts). 2009, 27 (15S): LBA8002-
Google Scholar
O'Byrne KJ, Bondarenko I, Barrios C, Eschbach C, Martens U, Hotko Y, Kortsik C, Celik I, Stroh C, Pirker R: Molecular and clinical predictors of outcome for cetuximab in non-small cell lung cancer (NSCLC): Data from the FLEX study. J Clin Oncol (Meeting Abstracts). 2009, 27 (15S): 8007-
Google Scholar
Pirker R, Pereira JR, Szczesna A, von Pawel J, Krzakowski M, Ramlau R, Vynnychenko I, Park K, Yu CT, Ganul V: Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial. Lancet. 2009, 373 (9674): 1525-1531. 10.1016/S0140-6736(09)60569-9.
Article
CAS
PubMed
Google Scholar
Hirsch FR, Herbst RS, Olsen C, Chansky K, Crowley J, Kelly K, Franklin WA, Bunn PA, Varella-Garcia M, Gandara DR: Increased EGFR gene copy number detected by fluorescent in situ hybridization predicts outcome in non-small-cell lung cancer patients treated with cetuximab and chemotherapy. J Clin Oncol. 2008, 26 (20): 3351-3357. 10.1200/JCO.2007.14.0111.
Article
PubMed Central
CAS
PubMed
Google Scholar
vKhambata-Ford S, Harbison CT, Hart LL, Award M, Xu L: K-RAS mutations and EGFR-related markers as potential predictors of the cetuximab benefit in 1st line advanced non-small cell lung cancer: results from the BMS099 study. Journal of Thoracic Oncology. 2008, 3 (11): S304-
Google Scholar
Gandara D, Kim ES, Herbst RS, Moon J, Redman MW, Dakhil SR, Hirsch F, Mack PC, Franklin W, Kelly K: S0536: Carboplatin, paclitaxel, cetuximab, and bevacizumab followed by cetuximab and bevacizumab maintenance in advanced non-small cell lung cancer (NSCLC): A SWOG phase II study. J Clin Oncol (Meeting Abstracts). 2009, 27 (15S): 8015-
Google Scholar
Kim ES, Hirsh V, Mok T, Socinski MA, Gervais R, Wu YL, Li LY, Watkins CL, Sellers MV, Lowe ES: Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial. Lancet. 2008, 372 (9652): 1809-1818. 10.1016/S0140-6736(08)61758-4.
Article
CAS
PubMed
Google Scholar
Park K, Goto K: A review of the benefit-risk profile of gefitinib in Asian patients with advanced non-small-cell lung cancer. Curr Med Res Opin. 2006, 22 (3): 561-573. 10.1185/030079906X89847.
Article
CAS
PubMed
Google Scholar
Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ: EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004, 304 (5676): 1497-1500. 10.1126/science.1099314.
Article
CAS
PubMed
Google Scholar
Paz-Ares L, Sanchez JM, Garcia-Velasco A, Massuti B, Lopez-Vivanco G, Provencio M, Montes A, Isla D, Amador ML, Rosell R: A prospective phase II trial of erlotinib in advanced non-small cell lung cancer (NSCLC) patients (p) with mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR). J Clin Oncol (Meeting Abstracts). 2006, 24 (18_suppl): 7020-
Google Scholar
Mok TS, Wu YL, Thongprasert S, Yang CH, Chu DT, Saijo N, Sunpaweravong P, Han B, Margono B, Ichinose Y: Gefitinib or Carboplatin-Paclitaxel in Pulmonary Adenocarcinoma. N Engl J Med. 2009, 361 (10): 947-957. 10.1056/NEJMoa0810699.
Article
CAS
PubMed
Google Scholar
Fukuoka M, Wu Y, Thongprasert S, Yang C, Chu D, Saijo N, Watkins C, Duffield E, Armour A, Mok T: Biomarker analyses from a phase III, randomized, open-label, first-line study of gefitinib (G) versus carboplatin/paclitaxel (C/P) in clinically selected patients (pts) with advanced non-small cell lung cancer (NSCLC) in Asia (IPASS). J Clin Oncol (Meeting Abstracts). 2009, 27 (15S): 8006-
Google Scholar
Herbst RS, Heymach JV, O'Reilly MS, Onn A, Ryan AJ: Vandetanib (ZD6474): an orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis. Expert Opin Investig Drugs. 2007, 16 (2): 239-249. 10.1517/13543784.16.2.239.
Article
CAS
PubMed
Google Scholar
Holden SN, Eckhardt SG, Basser R, de Boer R, Rischin D, Green M, Rosenthal MA, Wheeler C, Barge A, Hurwitz HI: Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors. Ann Oncol. 2005, 16 (8): 1391-1397. 10.1093/annonc/mdi247.
Article
CAS
PubMed
Google Scholar
Heymach JV, Johnson BE, Prager D, Csada E, Roubec J, Pesek M, Spasova I, Belani CP, Bodrogi I, Gadgeel S: Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer. J Clin Oncol. 2007, 25 (27): 4270-4277. 10.1200/JCO.2006.10.5122.
Article
CAS
PubMed
Google Scholar
Herbst RS, Sun Y, Korfee S, Germonpre P, Saijo N, Zhou C, Wang J, Langmuir P, Kennedy SJ, Johnson BE: Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind phase III trial (ZODIAC). J Clin Oncol (Meeting Abstracts). 2009, 27 (15S): CRA8003-
Google Scholar
De Boer R, Arrieta O, Gottfried M, Blackhall FH, Raats J, Yang CH, Langmuir P, Milenkova T, Read J, Vansteenkiste J: Vandetanib plus pemetrexed versus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind phase III trial (ZEAL). J Clin Oncol (Meeting Abstracts). 2009, 27 (15S): 8010-
Google Scholar
Natale RB, Thongprasert S, Greco FA, Thomas M, Tsai CM, Sunpaweravong P, Ferry D, Langmuir P, Rowbottom JA, Goss GD: Vandetanib versus erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after failure of at least one prior cytotoxic chemotherapy: A randomized, double-blind phase III trial (ZEST). J Clin Oncol (Meeting Abstracts). 2009, 27 (15S): 8009-
Google Scholar
Bolden JE, Peart MJ, Johnstone RW: Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov. 2006, 5 (9): 769-784. 10.1038/nrd2133.
Article
CAS
PubMed
Google Scholar
Traynor AM, Dubey S, Eickhoff JC, Kolesar JM, Schell K, Huie MS, Groteluschen DL, Marcotte SM, Hallahan CM, Weeks HR: Vorinostat (NSC# 701852) in patients with relapsed non-small cell lung cancer: a Wisconsin Oncology Network phase II study. J Thorac Oncol. 2009, 4 (4): 522-526. 10.1097/JTO.0b013e3181952478.
Article
PubMed Central
PubMed
Google Scholar
Ramalingam SS, Parise RA, Ramanathan RK, Lagattuta TF, Musguire LA, Stoller RG, Potter DM, Argiris AE, Zwiebel JA, Egorin MJ: Phase I and pharmacokinetic study of vorinostat, a histone deacetylase inhibitor, in combination with carboplatin and paclitaxel for advanced solid malignancies. Clin Cancer Res. 2007, 13 (12): 3605-3610. 10.1158/1078-0432.CCR-07-0162.
Article
CAS
PubMed
Google Scholar
Ramalingam SS, Maitland M, Frankel P, Argiris AE, Koczywas M, Gitlitz B, Espinoza-Delgado I, Vokes EE, Gandara DR, Belani CP: Randomized, double-blind, placebo-controlled phase II study of carboplatin and paclitaxel with or without vorinostat, a histone deacetylase inhibitor (HDAC), for first-line therapy of advanced non-small cell lung cancer (NCI 7863). J Clin Oncol (Meeting Abstracts). 2009, 27 (15S): 8004-
Google Scholar