Table 1 Approaches used in the treatment of acute graft-versus-host disease following orthotopic liver transplantation
From: Acute graft versus host disease after orthotopic liver transplantation
| Most common treatments | Corticosteroids (most), calcineurin inhibitors (many), granulocyte colony stimulating factors (many) |
|---|---|
| Antimetabolites | Azathioprine [30] |
| Alkylating agents | Cyclophosphamide [24] |
| Anti-T cell antibodies | Anti-thymocyte globulin [5, 19, 24, 31–45] |
| OKT3 [24, 42] | |
| Campath [38, 46, 47] | |
| Alefacept [43] | |
| Anti-B cell antibodies | Rituximab [46, 48] |
| Immunoglobulin | Immunoglobulin [4, 49, 50] |
| Cytokine inhibitors | Infliximab (TNF) [3, 31] |
| Etanercept (TNF) [51] | |
| Daclizumab (IL2R) [3, 38, 41, 46, 52–54] | |
| Basiliximab (IL2R) [5, 39, 44, 47, 48, 55, 56] | |
| Immunostimulants | Thymosin alpha 1 [4, 41] |
| Cellular therapy | Ex vivo T cell expansion [47] |
| Hematopoietic cell transplantation [24, 32, 34] |