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Figure 1 | Journal of Hematology & Oncology

Figure 1

From: The role of telomeres and telomerase in hematologic malignancies and hematopoietic stem cell transplantation

Figure 1

The structure of shelterin. TRF1 and TRF2 bind to double strand (ds) DNA and form two separate complexes with other shelterin proteins. POT1 binds to single strand (ss) DNA while RAP1 binds to DNA at the ds-ss joint. PINX1 is a TRF1 binding protein. TIN2 binds TRF1 and TRF2 spontaneously and protects TRF1 from being degraded by tankyrase. TPP1 and POT1 form a heterodimer. TPP1 links TIN2 and POT1/TPP1 and recruits telomerase to the shelterin complex.

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Journal of Hematology & Oncology

ISSN: 1756-8722

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