Fig. 3From: STUMP un“stumped”: anti-tumor response to anaplastic lymphoma kinase (ALK) inhibitor based targeted therapy in uterine inflammatory myofibroblastic tumor with myxoid features harboring DCTN1-ALK fusionThe DCTN1-ALK intra-chromosomal rearrangement detected in this case conformed to the common structural organization of ALK fusions, with the vast majority having an ALK intron 19 breakpoint and is a priori suspected to active in vivo. The DCTN1 component of the fusion contains exons including the coiled-coil domains, which is similar to other previously reported ALK fusion partners. Via these domains, DCTN1 is suspected to promote dimerization of ALK and subsequent kinase activation by transphosphorylationBack to article page