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Table 1 Diagnostic criteria for solitary plasmacytoma and overlapping disorders

From: Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel

   Plasmacytoma Serum monoclonal protein Bone marrow cytology End organ damage Radiological work-up Risk of progression
Solitary
plasmacytoma
Solitary plasmacytoma Present Not required Negative   No other lesions 10% will progress to MM within 3 years
Solitary plasmacytoma with minimal bone marrow involvement Present Not required Monoclonal PC infiltration < 10% Absent No other lesions 60% with SBP or 20% with EMP will progress to MM within 3 years
Multiple
myeloma
Macrofocal myeloma Present Not required Monoclonal PC infiltration < 10% Possible Multiple lesions  
Multiple myeloma Not required Present Monoclonal PC infiltration ≥ 10% Present Other lesions could be present
  1. Abbreviations: MM multiple myeloma, BM bone marrow, PC plasma cell, EMP extrameddulary plasmacytoma