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Matczak E. et al.: A phase 1, first-in-man, multicenter, open-label, dose-escalation study of single-agent GBR 1302 in subjects with HER2 positive cancers. https://clinicaltrials.gov/ct2/show/NCT02829372. Accessed 3 June 2019.
Gray MA, Tao RN, DePorter SM, Spiegel DA, McNaughton BR. A nanobody activation immunotherapeutic that selectively destroys HER2-positive breast Cancer cells. Chembiochem. 2016;17(2):155–8.
An open-label, multicenter, dose-escalation, phase Ia/Ib study to evaluate safety, pharmacokinetics, and therapeutic activity of RO6874281, an immunocytokine consisting of interleukin 2 variant (IL-2v) targeting fibroblast activation protein-α (FAP), as a single agent (Part A) or in combination with trastuzumab or cetuximab (Part B or C). https://clinicaltrials.gov/ct2/show/NCT02627274. Accessed 3 June 2019.
An investigator-initiated, non-randomised, phase II study of combination CTLA-4 and PD-L1 blockade in combination with HER2 blockade in advanced HER2-positive breast cancers that have progressed on prior trastuzumab-based therapy. Current clinical trials. DIAmOND BCT 1703. Breast Cancer Trials website.
A randomized, phase ii study comparing trastuzumab and vinorelbine in combination with avelumab or avelumab and utomilumab (41BB/CD137 Agonist), in patients With HER2-positive metastatic breast cancer who have progressed on prior trastuzumab and pertuzumab. .https://clinicaltrials.gov/ct2/show/NCT03414658.
A randomized, double-blind, phase iii trial of paclitaxel/trastuzumab/pertuzumab with atezolizumab or placebo in first-line HER2-positive metastatic breast cancer.https://clinicaltrials.gov/ct2/show/NCT03199885. Accessed 3 June 2019.
Phase II trial of combination immunotherapy with nelipepimut-S + GM-CSF (NeuVax™) and trastuzumab in high-risk HER2+ breast cancer patients. https://clinicaltrials.gov/ct2/show/NCT02297698. Accessed 3 June 2019.
Phase II trial evaluating the toxicity and efficacy of a multiepitope dendritic cell vaccine given with trastuzumab and vinorelbine ditartrate for the treatment of women with metastatic breast cancer that express HLA-A0201 and Whose tumors overexpress HER-2/NEU. https://clinicaltrials.gov/ct2/show/NCT00266110. Accessed 3 June 2019.
A clinical research of CAR T cells targeting HER2 positive cancer. https://clinicaltrials.gov/ct2/show/NCT02713984. Accessed 3 June 2019.
Clinical trial of atezolizumab with paclitaxel, trastuzumab, and pertuzumab in patients with metastatic HER-2 positive breast cancer. https://clinicaltrials.gov/ct2/show/NCT03125928. Accessed 3 June 2019.
A phase Ib, open-label study evaluating the safety and pharmacokinetics of atezolizumab (Anti−PD-L1 Antibody) in combination with trastuzumab emtansine or with trastuzumab and pertuzumab (with and without docetaxel) in patients with HER2-positive breast cancer and atezolizumab with doxorubicin and cyclophosphamide in HER2-negative breast cancer. https://clinicaltrials.gov/ct2/show/NCT02605915. Accessed 3 June 2019.
A phase ii study of atezolizumab in combination with pertuzumab plus high-dose trastuzumab for the treatment of central nervous system metastases in patients with Her2-positive breast cancer. https://clinicaltrials.gov/ct2/show/NCT03417544. Accessed 3 June 2019.
Phase II study of a HER-2/Neu (HER2) intracellular domain (icd) peptide-based vaccine administered to patients with locally advanced or stage IV HER2 positive breast cancer. https://clinicaltrials.gov/ct2/show/NCT00343109. Accessed 3 June 2019.
Chimeric antigen receptor-modified T cells for HER-2 positive recurrent and metastatic breast cancer. https://clinicaltrials.gov/ct2/show/NCT02547961. Accessed 3 June 2019.
A phase 1B dose escalation trial of human Anti-4-1BB agonistic antibody PF-05082566 in combination with adotrastuzumab-emtansine or trastuzumab in patients with HER2-positive advanced breast cancer. https://clinicaltrials.gov/ct2/show/NCT03364348. Accessed 3 June 2019.
Phase I/II randomized study of combination immunotherapy with or without polysaccharide krestin (PSK®) concurrently with a HER2 ICD peptide-based vaccine in patients with Stage IV breast cancer receiving HER2-targeted monoclonal antibody therapy. https://clinicaltrials.gov/ct2/show/NCT01922921. Accessed 3 June 2019.
A phase 1b study of pembrolizumab in combination with trastuzumab-DM1 in metastatic HER2-positive breast cancer.https://clinicaltrials.gov/ct2/show/NCT03032107. Accessed 3 June 2019.
A phase I study of a DNA plasmid based vaccine encoding the HER-2/Neu intracellular domain in subjects with HER-2/Neu (HER2) overexpressing tumors. In.: https://clinicaltrials.gov/ct2/show/NCT00436254. Accessed 3 June 2019.
Phase I/II study of combination immunotherapy for the generation of HER-2/Neu (HER2) specific cytotoxic T cells (CTL) in vivo. https://clinicaltrials.gov/ct2/show/NCT00194714. Accessed 3 June 2019.
VISTA (VIrus Specific T Cells and Adenovirus): a first in human phase I trial of binary oncolytic adenovirus in combination with HER2-specific CAR VST cells in patients with advanced her2 positive solid tumors. https://clinicaltrials.gov/ct2/show/NCT03740256. Accessed 3 June 2019.
Atezolizumab, pertuzumab and trastuzumab with chemotherapy as neoadjuvant treatment of HER2 positive early high-risk and locally advanced breast cancer (APTneo).https://clinicaltrials.gov/ct2/show/NCT03595592. Accessed 3 June 2019.
A phase III, randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of atezolizumab or placebo in combination with neoadjuvant doxorubicin + cyclophosphamide followed by paclitaxel + trastuzumab + pertuzumab in early Her2-positive breast cancer. https://clinicaltrials.gov/ct2/show/NCT03726879. Accessed 3 June 2019.
Combination immunotherapy with herceptin and the HER2 vaccine E75 in low and intermediate HER2-expressing breast cancer patients to prevent recurrence. https://clinicaltrials.gov/ct2/show/NCT01570036. Accessed 3 June 2019.
PRESENT: prevention of recurrence in early-stage, node-positive breast cancer with low to intermediate HER2 expressions with NeuVax™Treatment. https://clinicaltrials.gov/ct2/show/NCT01479244. Accessed 3 June 2019.
Phase 2 study of MCLA-128-based combinations in metastatic breast cancer (MBC): MCLA-128/trastuzumab/chemotherapy in HER2-positive MBC and MCLA-128/endocrine therapy in estrogen receptor positive and low HER2 expression MBC. https://clinicaltrials.gov/ct2/show/NCT03321981. Accessed 3 June 2019.
Neoadjuvant Her2-targeted therapy and immunotherapy with pembrolizumab (neoHIP). https://clinicaltrials.gov/ct2/show/NCT03747120. Accessed 3 June 2019.
Phase I-II study of HER2 vaccination with Poly(I) • Poly(C12U) (Ampligen®) as an adjuvant in optimally treated breast cancer patients. https://clinicaltrials.gov/ct2/show/NCT01355393. Accessed 3 June 2019.
Phase II trial of nivolumab with chemotherapy as neoadjuvant treatment in inflammatory breast cancer (IBC). https://clinicaltrials.gov/ct2/show/NCT03742986. Accessed 3 June 2019.
A pilot study utilizing a her2 directed dendritic cell vaccine during neoadjuvant therapy of HER2+ breast cancer. https://clinicaltrials.gov/ct2/show/NCT03387553. Accessed 3 June 2019.
Immune response surveillance and potential booster vaccines for patients who have received HER2-pulsed DC1 vaccine. https://clinicaltrials.gov/ct2/show/NCT03630809. Accessed 3 June 2019.
A pilot single arm open label trial evaluating M7824 (Anti-PD-L1/TGF-Beta TRAP) in a window setting in patients with Stage II-III HER2/Neu Positive (HER2+) breast cancer (BC). https://clinicaltrials.gov/ct2/show/NCT03620201. Accessed 3 June 2019.
Multicenter phase II trial of durvalumab (MEDI4736) with trastuzumab and pertuzumab combination in HER2-enriched and HER2-amplified breast cancer (DTP Trial). https://clinicaltrials.gov/ct2/show/NCT03820141. Accessed 3 June 2019.
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