Fig. 2
From: Gene modification strategies for next-generation CAR T cells against solid cancers
CAR with JAK/STAT signaling. The 28-IL2RB-z(YXXQ) CAR induces the phosphorylation of JAK kinases after antigen engagement, resulting in the phosphorylation of STAT3 and STAT5. Phosphorylated STAT3 (pSTAT3) and STAT5 (pSTAT5) subsequently homodimerize and translocate into the nucleus to regulate the transcription of target genes, which leads to the enhanced proliferation and reduced terminal differentiation of CAR T cells.