Ethics approval and consent to participate
The study protocol was approved by an independent ethics committee or institutional review board at each study center and was conducted in accordance with the principles of the Declaration of Helsinki and the International Conference on Harmonisation Good Clinical Practice guidelines. All patients provided written informed consent.
Consent for publication
Not applicable.
Competing interests
KW received honoraria from GlaxoSmithKline, Sanofi, Adaptive, Amgen, Bristol-Myers Squibb, Celgene, Janssen, and Takeda; served in a consulting or advisory role for GlaxoSmithKline, Amgen, Adaptive, Bristol-Myers Squibb, Celgene, Janssen, Takeda, Sanofi, and Juno; and received institutional research funding from Amgen, Celgene, Sanofi, and Janssen. AS received honoraria from Celgene, Janssen, Amgen, AbbVie, Servier, and Takeda; served in a consulting or advisory role for Celgene, Janssen, Servier, and AbbVie; and served on a speakers bureau for and received institutional funding from Janssen, Takeda, and Celgene. SL holds stock and patents, royalties, or other intellectual property from Caelum Biosciences; served in a consulting or advisory role for Caelum Biosciences, Takeda, Janssen, Celgene, Bristol-Myers Squibb, AbbVie, and Bayer; received research funding from Sanofi; declared another relationship with Clinical Care Options; and served on data safety monitoring boards for Sorrento and Bayer. TMM holds stock in AbbVie; received honoraria and research funding from Celgene; and served in a consulting or advisory role for Janssen, Takeda, and Adaptive. M-DL is a consultant for and receives honoraria and travel support from AbbVie, Celgene, Amgen, and Janssen. AB received honoraria from Amgen; served in a consulting or advisory role for Takeda; and had travel, accommodations, or other expenses paid or reimbursed by Celgene, Janssen, and Amgen. VH served in a consulting or advisory role and on a speakers bureau for AbbVie, Amgen, Celgene, Janssen, Takeda, and Bristol-Myers Squibb. MCavo received honoraria from Celgene, Janssen, Amgen, Bristol-Myers Squibb, AbbVie, and Takeda; served in a consulting or advisory role for Janssen, Celgene, Amgen, and AbbVie; and served on a speakers bureau for and had travel, accommodations, or other expenses paid or reimbursed by Janssen and Celgene. AN received honoraria from and served in a consulting or advisory role for Janssen, GlaxoSmithKline, Celgene, Amgen, Takeda, Spectrum, Bristol-Myers Squibb, Karyopharm, Oncopeptides, and Adaptive and received research funding from Janssen, GlaxoSmithKline, Celgene, Amgen, Takeda, Karyopharm, and Bristol-Myers Squibb. HQ served in a consulting or advisory role for Celgene, Amgen, Karyopharm, and GlaxoSmithKline and received research funding from Celgene and Amgen. MM received honoraria from Janssen, Bristol-Myers Squibb, Celgene, and Amgen; served in a consulting or advisory role for Janssen, Bristol-Myers Squibb, Takeda, Celgene, Amgen, and Heidelberg Pharma; received research funding from Incyte and Bristol-Myers Squibb; and had travel, accommodations, or other expenses paid or reimbursed by Janssen, Bristol-Myers Squibb, Takeda, Celgene, and Amgen. CL received honoraria from and consulted for Amgen, Janssen-Cilag, Takeda, and Celgene. PC received honoraria from Daiichi Sankyo, Kite, KiowaKirin, Celgene, Janssen, Novartis, Roche, Takeda, Sanofi, Amgen, Gilead, and AbbVie and had travel, accommodations, or other expenses paid or reimbursed by Novartis, Janssen, Celgene, Bristol-Myers Squibb, Takeda, Gilead, Amgen, and AbbVie. AAC-K received research funding from the Mayo Clinic. NH served on the board of directors or advisory committees for Janssen. MCapra received honoraria from AbbVie, GlaxoSmithKline, Bristol-Myers Squibb, Adaptive, Takeda, Janssen, and Celgene. MB served in a consulting or advisory role and on a speakers bureau for Amgen, Janssen, and Takeda. RO consulted for Janssen. PS received honoraria from and research funding from Amgen, Celgene, Janssen, SkylineDx, and Takeda. TC is an employee of Janssen and holds stock options from Johnson & Johnson. ND, HA, JU, and RK are employees of Janssen. M-VM received honoraria from and served in a consulting or advisory role for Janssen, Celgene, Amgen, Takeda, GlaxoSmithKline, AbbVie, Seattle Genetics, and Adaptive. HA-L, IS, TM, BL, J-JL, WB, C-KM, J-CJ, and H-JS have no conflicts of interest to disclose.