Fig. 2
From: Targeting MCL-1 in cancer: current status and perspectives
The isoforms and three-dimensional structure of MCL-1. a Three splicing variants of the human MCL-1 gene. b Cartoon representation of the tertiary structure of MCL-1 (PDB ID: 6QB3). The BH core of MCL-1 is composed of eight α helices. The BH1 (blue), BH2 (yellow) and BH3 (red) domains form a hydrophobic groove called the BH3-binding groove. c Surface representation of the BH3 binding groove of MCL-1 (PDB ID: 2NL9). The four hydrophobic pockets (P1–4) are highlighted and labelled. d Structure of the MCL-1/BIM complex (PDB ID: 2NL9). MCL-1 is shown as surface. BIM is shown as cyan cartoon. The four hydrophobic residues of BIM (h1, h2, h3, h4) are shown as cyan sticks