- Letter to the Editor
- Open Access
Development and validation of a novel online calculator for estimating survival benefit of adjuvant transcatheter arterial chemoembolization in patients undergoing surgery for hepatocellular carcinoma
Journal of Hematology & Oncology volume 14, Article number: 165 (2021)
Background and aims
Although adjuvant transcatheter arterial chemoembolization (TACE) for resected hepatocellular carcinoma (HCC) may improve survival for some patients, identifying which patients can benefit remains challenging. The present study aimed to construct a survival prediction calculator for individualized estimating the net survival benefit of adjuvant TACE for patients with resected HCC.
From a multicenter database, consecutive patients undergoing curative resection for HCC were enrolled and divided into the developing and validation cohorts. Using the independent survival predictors in the developing cohort, two nomogram models were constructed for patients with and without adjuvant TACE, respectively, which predictive performance was validated internally and externally by measuring concordance index (C-index) and calibration. The difference between two estimates of the prediction models was the expected survival benefit of adjuvant TACE.
A total of 2514 patients met the inclusion criteria for the study. The nomogram prediction models for patients with and without adjuvant TACE were, respectively, built by incorporating the same eight independent survival predictors, including portal hypertension, Child–Pugh score, alpha-fetoprotein level, tumor size and number, macrovascular and microvascular invasion, and resection margin. These two prediction models demonstrated good calibration and discrimination, with all the C-indexes of greater than 0.75 in the developing and validation cohorts. A browser-based calculator was generated for individualized estimating the net survival benefit of adjuvant TACE.
Based on large-scale real-world data, an easy-to-use online calculator can be adopted as a decision aid to predict which patients with resected HCC can benefit from adjuvant TACE.
To the editor,
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality worldwide . Surgical resection represents a common approach to treat HCC and provides the possibility of cure . Long-term prognosis after HCC resection is, however, still poor due to the high incidence of recurrence [3,4,5]. Transcatheter arterial chemoembolization (TACE) has been used in the postoperative setting as a means to decrease risk of recurrence and improve survival [6,7,8]. Whereas, in clinical practice, controversy persists relative to the role of adjuvant TACE for resected HCC [9,10,11]. The reasons for these disparate results are undoubtedly multifactorial, yet may relate to patient selection. Specifically, only certain high-risk patients with resected HCC may benefit from adjuvant TACE . The objective of the current study was to construct a decision aid using a large multicenter database to predict which patient with resected HCC had a survival benefit from adjuvant TACE. In addition, we sought to estimate the magnitude of the survival benefit for given individual patients. A web-based decision tool was provided for clinicians and patients to aid in the decision-making process regarding adjuvant TACE after HCC resection. Patients and methods for this study are described in detail in Additional file 1.
All 2514 patients with HCC underwent curative liver resection were included (Additional file 2: Figure S1). Among them, 1755 and 759 patients were randomly segregated to the development and validation cohort, respectively (Table 1). Compared with patients who did not receive adjuvant TACE, patients who had adjuvant TACE had a longer survival in both the development and validation cohorts (all P < 0.001) (Additional file 3: Figure S2).
Independent predictors of survival
Univariable and multivariable Cox regression analyses of the development cohort demonstrated that independent predictors associated with overall survival after HCC resection among patients treated with and without adjuvant TACE included portal hypertension, Child–Pugh grade, preoperative AFP level, tumor size, tumor number, macrovascular invasion, microvascular invasion, and resection margin (all P < 0.05). (Additional file 4: Table S1 and Additional file 5: Table S2).
Development of the prediction models
Two different nomogram models that integrated independent factors associated with overall survival were constructed to predict outcomes among patients who did and did not receive adjuvant TACE (Fig. 1a, b). To estimate the net survival benefit from adjuvant TACE, these two nomograms were compared and the difference between the two estimates was the expected net survival benefit from the addition of adjuvant TACE.
Validation of the prediction models
Bootstrapping with 400 resamples in the development cohort demonstrated good predictive performance, with the C-indexes of 0.791 (95% CI 0.742–0.840) and 0.810 (95% CI 0.779–0.841) for patients with and without adjuvant TACE, respectively. Accordingly, the C-indices were 0.756 (95% CI 0.678–0.834) and 0.765 (95% CI 0.720–0.810) in the validation cohort. There was also good calibration curve to predict 3- and 5-year survival probabilities among patients treated with and without adjuvant TACE, respectively (all P > 0.05) (Fig. 1c, d).
Construction of the online calculator
Based on the formula of the nomogram prediction models, an Internet browser-based software tool was constructed to predict the net survival benefit of adjuvant TACE for an individual patient, including the expected net survival time, and the increased 3- and 5-year survival probabilities (Fig. 1e). The corresponding score and the formula to calculate survival probability were provided (Additional file 6: Table S3). The online calculator is available for free use at: http://asapcalculate.top/Cal5_en.html. After the user inputs all the requested information relative to the prognostic factors, the predicted survival improvement associated with the addition of adjuvant TACE, including the expected survival time and the 3- and 5-year survival probabilities, is generated and displayed.
In summary, a survival prediction model that incorporated eight independent variables associated with survival was constructed to derive an individualized estimate of the net survival benefit of adding adjuvant TACE to a patient’s post-resection HCC treatment plan. The nomograms and online calculator had good predictive accuracy, and discrimination was validated. The calculator may help provide an estimate of the net survival benefit associated with adjuvant TACE for an individual patient following HCC resection. This tool may assist clinicians and patients in quantifying the benefit of adjuvant TACE after HCC resection and inform real-word discussions on this topic.
Transcatheter arterial chemoembolization
Randomized controlled trial
Magnetic resonance imaging
Eastern cooperativse oncology group
American society of anesthesiologists
Hepatitis B virus; HCV, hepatitis C virus
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Funding for the study was provided by the National Natural Science Foundation of China (Nos. 81672699 and 81972726, Dr Yang). Role of the Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study was conducted in accordance with the Declaration of Helsinki and the Ethical Guidelines for Clinical Studies of all participating hospitals.
The study protocol was approved by the Institutional Review Board of all participating hospitals, and informed consent from the patients was waived. Written, informed consent for the data to be used for clinical researches was obtained from all enrolled patients.
The abstract of this study has been presented as an oral presentation in the Congress of “the 11th Asia-Pacific Primary Liver Cancer Expert, APPLE 2021” (August 13–15, 2021, Korea), and has been also presented as an oral presentation in the Congress of “the LIVER WEEK 2021” (May 13–15, 2021, Korea) and won a “Foreign Investigator Award”.
All authors declare that they have no conflict of interest.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Patients and methods.
Flow chart of patient inclusion.
(A) Kaplan-Meier curves of overall survival between patients in the development and validation cohorts (log-rank test, P = 0.594); (B) Kaplan-Meier curves of overall survival between patients with and without adjuvant TACE in the developing cohort (log-rank test, P < 0.001); and (C) Kaplan-Meier curves of overall survival between patients with and without adjuvant TACE in the validation cohort (log-rank test, P < 0.001). Number of patients at risk and censoring were list in the box at the bottom of each plot.
Univariable and multivariable Cox-regression analyses of predicting overall survival for patients with resected hepatocellular carcinoma who underwent adjuvant TACE in the developing cohort.
Univariable and multivariable Cox-regression analyses of predicting overall survival for patients with resected hepatocellular carcinoma who did not undergo adjuvant TACE in the developing cohort.
The corresponding score and the formula of our nomogram models.
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Cite this article
Liang, L., Li, C., Wang, MD. et al. Development and validation of a novel online calculator for estimating survival benefit of adjuvant transcatheter arterial chemoembolization in patients undergoing surgery for hepatocellular carcinoma. J Hematol Oncol 14, 165 (2021). https://doi.org/10.1186/s13045-021-01180-5
- Hepatocellular carcinoma
- Transcatheter arterial chemoembolization
- Adjuvant therapy