Table 5 Targeting cell metabolism for cancer treatment

Tyrosine kinase

PLX3397

1

Prostate adenocarcinoma

Barbara Ann Karmanos Cancer Institute

NCT02472275

Cholesterol

Tesco

Not applicable

Breast cancer

University of Leeds

NCT04147767

mTOR

Sirolimus

1/2

Pancreatic cancer

Second Affiliated Hospital, School of Medicine, Zhejiang University

NCT03662412

Glucose metabolism

Metformin

2

Breast cancer

Oxford University Hospitals NHS Trust

NCT01266486

1

Head and neck squamous cell cancer

Sidney Kimmel Cancer Center at Thomas Jefferson University

NCT02083692

1

Cancer of head and neck

West Virginia University

NCT02402348

2

Lung cancer

M.D. Anderson Cancer Center

NCT02285855

1

Endometrial cancer

M.D. Anderson Cancer Center

NCT01205672

2-DG

1/2

Prostate cancer

Rutgers, The State University of New Jersey

NCT00633087

Intracranial neoplasms

NCT00247403

Neoplasm metastasis

PPARγ

Rosiglitazone

2

Melanoma

Dan Zandberg

NCT04114136

Nsclc

Hepatocellular carcinoma

Dichloroacetate

1

Head and neck cancer

Daniel T. Chang

NCT01163487

Pioglitazone

2

Cancer of the pancreas

University of Texas Southwestern Medical Center

NCT01838317

Cholesterol

Evolocumab

1

Pancreatic ductal adenocarcinoma

CHU de Quebec-Universite Laval

NCT04862260

1

Glioblastoma

Duke University

NCT04937413

Atorvastatin

Pancreatic cancer

Ezetimibe

Pancreas cancer

Metastatic cancer

HMG-CoA reductase

Rosuvastatin

4

Prostate cancer metastatic

National Cancer Institute, Egypt

NCT04776889

Arginase

INCB001158

1/2

Metastatic cancer

Incyte Corporation

NCT02903914

Solid tumours

Colorectal cancer

Gastric cancer

1

Advanced solid tumours

Advanced solid tumours

NCT03910530

Advanced solid tumours

1/2

Biliary tract cancer

Incyte Corporation

NCT03314935

Colorectal cancer

Endometrial cancer

1/2

Solid tumours

Incyte Corporation

NCT03361228