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  1. Uncontrolled cell division is the hallmark of cancers. Full understanding of cell cycle regulation would contribute to promising cancer therapies. In particular, cyclin-dependent kinases 4/6 (CDK4/6), which ar...

    Authors: Hanxiao Xu, Shengnan Yu, Qian Liu, Xun Yuan, Sridhar Mani, Richard G. Pestell and Kongming Wu
    Citation: Journal of Hematology & Oncology 2017 10:97
    Content type: Review Published on:

  3. Patients with advanced melanoma have a compromised anti-tumor immune response leading to tumor immune tolerance and a tumor microenvironment conducive to disease progression. Immunotherapy that successfully ov...

    Authors: Tala Achkar and Ahmad A. Tarhini
    Citation: Journal of Hematology & Oncology 2017 10:88
    Content type: Review Published on:

  5. Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, and tumor recurrence and metastasis are major factors that contribute to the poor outcome of patients with HCC. Long noncoding R...

    Authors: Wen Ni, Yuqin Zhang, Zetao Zhan, Feng Ye, Yonghao Liang, Jing Huang, Keli Chen, Longhua Chen and Yi Ding
    Citation: Journal of Hematology & Oncology 2017 10:91
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Hematology & Oncology 2023 16:51

  6. Acute myeloid leukemia (AML) is characterized by clinical and biological heterogeneity. Despite the advances in our understanding of its pathobiology, the chemotherapy-directed management has remained largely ...

    Authors: Caner Saygin and Hetty E. Carraway
    Citation: Journal of Hematology & Oncology 2017 10:93
    Content type: Review Published on:

  7. The B cell maturation process involves multiple steps, which are controlled by relevant pathways and transcription factors. The understanding of the final stages of plasma cell (PC) differentiation could provi...

    Authors: Dalia Quwaider, Luis A. Corchete, Irena Misiewicz-Krzeminska, María E. Sarasquete, José J. Pérez, Patryk Krzeminski, Noemí Puig, María Victoria Mateos, Ramón García-Sanz, Ana B. Herrero and Norma C. Gutiérrez
    Citation: Journal of Hematology & Oncology 2017 10:92
    Content type: Research Published on:

  8. The purpose of this study is to characterize the risk of cancer in a large cohort of patients with primary Sjögren syndrome (SjS).

    Authors: Pilar Brito-Zerón, Belchin Kostov, Guadalupe Fraile, Daniel Caravia-Durán, Brenda Maure, Francisco-Javier Rascón, Mónica Zamora, Arnau Casanovas, Miguel Lopez-Dupla, Mar Ripoll, Blanca Pinilla, Eva Fonseca, Miriam Akasbi, Gloria de la Red, Miguel-Angel Duarte-Millán, Patricia Fanlo…
    Citation: Journal of Hematology & Oncology 2017 10:90
    Content type: Research Published on:

  9. Estrogen and progesterone are potent breast mitogens. In addition to steroid hormones, multiple signaling pathways input to estrogen receptor (ER) and progesterone receptor (PR) actions via posttranslational e...

    Authors: Todd P. Knutson, Thu H. Truong, Shihong Ma, Nicholas J. Brady, Megan E. Sullivan, Ganesh Raj, Kathryn L. Schwertfeger and Carol A. Lange
    Citation: Journal of Hematology & Oncology 2017 10:89
    Content type: Research Published on:

  10. Extranodal natural killer (NK)/T-cell lymphoma is an aggressive malignancy of putative NK-cell origin, with a minority deriving from the T-cell lineage. Pathologically, the malignancy occurs in two forms, extr...

    Authors: Eric Tse and Yok-Lam Kwong
    Citation: Journal of Hematology & Oncology 2017 10:85
    Content type: Review Published on:

  11. Trabectedin has recently been approved in the USA and in Europe for advanced soft-tissue sarcoma patients who have been treated with anthracycline-based chemotherapy without success. The mechanism of action of...

    Authors: Audrey Laroche, Vanessa Chaire, François Le Loarer, Marie-Paule Algéo, Christophe Rey, Kevin Tran, Carlo Lucchesi and Antoine Italiano
    Citation: Journal of Hematology & Oncology 2017 10:84
    Content type: Rapid communication Published on:

  12. Chronic lymphocytic leukemia (CLL) is a highly genetically heterogeneous disease. Although CLL has been traditionally considered as a mature B cell leukemia, few independent studies have shown that the genetic...

    Authors: Miguel Quijada-Álamo, María Hernández-Sánchez, Cristina Robledo, Jesús-María Hernández-Sánchez, Rocío Benito, Adrián Montaño, Ana E. Rodríguez-Vicente, Dalia Quwaider, Ana-África Martín, María García-Álvarez, María Jesús Vidal-Manceñido, Gonzalo Ferrer-Garrido, María-Pilar Delgado-Beltrán, Josefina Galende, Juan-Nicolás Rodríguez, Guillermo Martín-Núñez…
    Citation: Journal of Hematology & Oncology 2017 10:83
    Content type: Research Published on:

  13. Dendritic cells (DCs) enhance the quality of anti-tumor immune response in patients with cancer. Thus, we posit that DC-based immunotherapy, in conjunction with toll-like receptor (TLR)-3 agonist poly-ICLC, is...

    Authors: Shikhar Mehrotra, Carolyn D. Britten, Steve Chin, Elizabeth Garrett-Mayer, Colleen A. Cloud, Mingli Li, Gina Scurti, Mohamed L. Salem, Michelle H. Nelson, Melanie B. Thomas, Chrystal M. Paulos, Andres M. Salazar, Michael I. Nishimura, Mark P. Rubinstein, Zihai Li and David J. Cole
    Citation: Journal of Hematology & Oncology 2017 10:82
    Content type: Research Published on:

  15. Pharmacological inhibition of B cell receptor (BCR) signaling has recently emerged as an effective approach in a wide range of B lymphoid neoplasms. However, despite promising clinical activity of the first Br...

    Authors: P. Balsas, A. Esteve-Arenys, J. Roldán, L. Jiménez, V. Rodríguez, J. G. Valero, A. Chamorro-Jorganes, R. Puig de la Bellacasa, J. Teixidó, A. Matas-Céspedes, A. Moros, A. Martínez, E. Campo, A. Sáez-Borderías, J. I. Borrell, P. Pérez-Galán…
    Citation: Journal of Hematology & Oncology 2017 10:80
    Content type: Research Published on:

  16. With persistent inconsistencies in colorectal cancer (CRC) miRNAs expression data, it is crucial to shift toward inclusion of a “pre-laboratory” integrated analysis to expedite effective precision medicine and...

    Authors: Min Sun, Haibin Song, Shuyi Wang, Chunxiao Zhang, Liang Zheng, Fangfang Chen, Dongdong Shi, Yuanyuan Chen, Chaogang Yang, Zhenxian Xiang, Qing Liu, Chen Wei and Bin Xiong
    Citation: Journal of Hematology & Oncology 2017 10:79
    Content type: Research Published on:

  17. The chimeric antigen receptor T (CAR-T) cell therapy is a newly developed adoptive antitumor treatment. Theoretically, CAR-T cells can specifically localize and eliminate tumor cells by interacting with the tu...

    Authors: Shengnan Yu, Anping Li, Qian Liu, Tengfei Li, Xun Yuan, Xinwei Han and Kongming Wu
    Citation: Journal of Hematology & Oncology 2017 10:78
    Content type: Review Published on:

  18. The inhibition of the DNA damage response (DDR) pathway in the treatment of cancers has recently reached an exciting stage with several cell cycle checkpoint inhibitors that are now being tested in several cli...

    Authors: A. Ghelli Luserna di Rora’, I. Iacobucci and G. Martinelli
    Citation: Journal of Hematology & Oncology 2017 10:77
    Content type: Review Published on:

  19. Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer generally refractory to conventional treatments. Cancer-associated fibroblasts (CAFs) are cellular components of the desmoplastic stroma characteristi...

    Authors: Dagny von Ahrens, Tushar D. Bhagat, Deepak Nagrath, Anirban Maitra and Amit Verma
    Citation: Journal of Hematology & Oncology 2017 10:76
    Content type: Review Published on:

  20. ELF2 (E74-like factor 2) also known as NERF (new Ets-related factor), a member of the Ets family of transcription factors, regulates genes important in B and T cell development, cell cycle progression, and angiog...

    Authors: Fiona H. X. Guan, Charles G. Bailey, Cynthia Metierre, Patrick O’Young, Dadi Gao, Teh Liane Khoo, Jeff Holst and John E. J. Rasko
    Citation: Journal of Hematology & Oncology 2017 10:75
    Content type: Research Published on:

  21. Current angiogenic therapies for cancers and cardiovascular diseases have not yet achieved expected benefits, which reflects the need for improved understanding of angiogenesis. In this study, we focused on so...

    Authors: Hangfei Fu, Nish Vadalia, Eric R. Xue, Candice Johnson, Luqiao Wang, William Y. Yang, Claudette Sanchez, Jun Nelson, Qian Chen, Eric T. Choi, Jian-Xing Ma, Jun Yu, Hong Wang and Xiaofeng Yang
    Citation: Journal of Hematology & Oncology 2017 10:74
    Content type: Research Published on:

  22. Hepcidin plays a central role in iron homeostasis and erythropoiesis. Neutralizing hepcidin with a monoclonal antibody (mAb) may prevent ferroportin internalization, restore iron efflux from cells, and allow t...

    Authors: Saroj Vadhan-Raj, Rafat Abonour, Jonathan W. Goldman, David A. Smith, Christopher A. Slapak, Robert L. Ilaria Jr, Ramon V. Tiu, Xuejing Wang, Sophie Callies, Joanne Cox, Jay L. Tuttle, Yiu-Keung Lau and Eric J. Roeland
    Citation: Journal of Hematology & Oncology 2017 10:73
    Content type: Research Published on:

  23. Polymeric fibronectin (polyFN) assembled on suspended breast cancer cells is required for metastasis. Conceivably, drugs that target such polyFN may fight against cancer metastasis. While stilbene analogs trig...

    Authors: Ying-Jan Wang, Jing-Fang Lin, Li-Hsin Cheng, Wen-Tsan Chang, Ying-Hsien Kao, Ming-Min Chang, Bour-Jr Wang and Hung-Chi Cheng
    Citation: Journal of Hematology & Oncology 2017 10:72
    Content type: Research Published on:

  24. Melittin is the main effective component of bee venom and has extensive biological functions; however, serious side effects have restricted its clinical application. Preclinical and clinical studies showed tha...

    Authors: Jie Mao, Shujun Liu, Min Ai, Zhuo Wang, Duowei Wang, Xianjing Li, Kaiyong Hu, Xinghua Gao and Yong Yang
    Citation: Journal of Hematology & Oncology 2017 10:71
    Content type: Letter to the Editor Published on:

    The Correction to this article has been published in Journal of Hematology & Oncology 2022 15:130

  25. Recently, the mutational background of diffuse large B cell lymphoma (DLBCL) has been revealed, identifying specific genetic events that drive lymphomagenesis. However, the prognostic value of these mutations ...

    Authors: Darius Juskevicius, David Jucker, Dirk Klingbiel, Christoph Mamot, Stephan Dirnhofer and Alexandar Tzankov
    Citation: Journal of Hematology & Oncology 2017 10:70
    Content type: Rapid communication Published on:

  26. The efficacy and safety of chidamide, a new subtype-selective histone deacetylase (HDAC) inhibitor, have been demonstrated in a pivotal phase II clinical trial, and chidamide has been approved by the China Foo...

    Authors: Yuankai Shi, Bo Jia, Wei Xu, Wenyu Li, Ting Liu, Peng Liu, Weili Zhao, Huilai Zhang, Xiuhua Sun, Haiyan Yang, Xi Zhang, Jie Jin, Zhengming Jin, Zhiming Li, Lugui Qiu, Mei Dong…
    Citation: Journal of Hematology & Oncology 2017 10:69
    Content type: Letter to the Editor Published on:

  27. Multiple iterations of chimeric antigen receptors (CARs) have been developed, mainly focusing on intracellular signaling modules. However, the effect of non-signaling extracellular modules on the expansion and...

    Authors: Le Qin, Yunxin Lai, Ruocong Zhao, Xinru Wei, Jianyu Weng, Peilong Lai, Baiheng Li, Simiao Lin, Suna Wang, Qiting Wu, Qiubin Liang, Yangqiu Li, Xuchao Zhang, Yilong Wu, Pentao Liu, Yao Yao…
    Citation: Journal of Hematology & Oncology 2017 10:68
    Content type: Rapid communication Published on:

  29. In the last decade, the role for noncoding RNAs in disease was clearly established, starting with microRNAs and later expanded towards long noncoding RNAs. This was also the case for T cell acute lymphoblastic...

    Authors: Annelynn Wallaert, Kaat Durinck, Tom Taghon, Pieter Van Vlierberghe and Frank Speleman
    Citation: Journal of Hematology & Oncology 2017 10:66
    Content type: Review Published on:

  30. Relapsed acute lymphoblastic leukemia (ALL) is the leading cause of deaths of childhood cancer. Although relapse usually happens in the bone marrow, extramedullary relapse occasionally occurs including either ...

    Authors: Ling-Wen Ding, Qiao-Yang Sun, Anand Mayakonda, Kar-Tong Tan, Wenwen Chien, De-Chen Lin, Yan-Yi Jiang, Liang Xu, Manoj Garg, Zhen-Tang Lao, Michael Lill, Henry Yang, Allen Eng Juh Yeoh and H. Phillip Koeffler
    Citation: Journal of Hematology & Oncology 2017 10:65
    Content type: Letter to the Editor Published on:

  31. Programmed cell death 1 (PD-1) and its ligand 1 (PD-L1) inhibitors have quickly become standard of care for patients with advanced non-small cell lung cancer and increasing numbers of other cancer types. In th...

    Authors: Hong Li, Weijie Ma, Ken Y. Yoneda, Elizabeth H. Moore, Yanhong Zhang, Lee L. Q. Pu, Garrett M. Frampton, Michael Molmen, Philip J. Stephens and Tianhong Li
    Citation: Journal of Hematology & Oncology 2017 10:64
    Content type: Case report Published on:

  32. Adoptive transfer of cytotoxic T lymphocytes (CTLs) holds promises to cure cancer. However, this treatment is hindered by lacking a robust way to specifically expand out CTLs. Here, we developed a hybrid of B ...

    Authors: Sheng Chen, Feifei Gu, Kang Li, Kai Zhang, Yangyang Liu, Jinyan Liang, Wei Gao, Gang Wu and Li Liu
    Citation: Journal of Hematology & Oncology 2017 10:63
    Content type: Letter to the Editor Published on:

  33. Cancer has been a major public health problem that has threatened human life worldwide throughout history. The main causes that contribute to the poor prognosis of cancer are metastasis and recurrence. Cancer ...

    Authors: Xiaoxing Huang, Ruijing Xiao, Shan Pan, Xiangyong Yang, Wen Yuan, Zhenbo Tu, Ming Xu, Yufan Zhu, Qian Yin, Yingjie Wu, Weidong Hu, Liang Shao, Jie Xiong and Qiuping Zhang
    Citation: Journal of Hematology & Oncology 2017 10:62
    Content type: Review Published on:

  34. Target-specific next-generation sequencing technology was used to analyze 112 genes in adult patients with acute lymphoblastic leukemia (ALL). This sequencing mainly focused on the specific mutational hotspots...

    Authors: Juan Feng, Yan Li, Yujiao Jia, Qiuyun Fang, Xiaoyuan Gong, Xiaobao Dong, Kun Ru, Qinghua Li, Xingli Zhao, Kaiqi Liu, Min Wang, Zheng Tian, Yannan Jia, Ying Wang, Dong Lin, Hui Wei…
    Citation: Journal of Hematology & Oncology 2017 10:61
    Content type: Letter to the Editor Published on:

  35. An increased expression of Yes-associated protein (YAP1) has been shown to promote tumorigenesis in many cancer types including colon. However, the role of YAP1 in promoting colon tumorigenesis remains unclear...

    Authors: Yan-Jiun Huang, Ching-Kuo Yang, Po-Li Wei, Thanh-Tuan Huynh, Jacqueline Whang-Peng, Tzu-Ching Meng, Michael Hsiao, Yew-Ming Tzeng, Alexander TH Wu and Yun Yen
    Citation: Journal of Hematology & Oncology 2017 10:60
    Content type: Research Published on:

  36. Arsenic trioxide (ATO) is commonly used in the treatment of acute promyelocytic leukemia (APL), but does not benefit patients with solid tumors. When combined with other agents or radiation, ATO showed treatme...

    Authors: Sunbin Ling, Haiyang Xie, Fan Yang, Qiaonan Shan, Haojiang Dai, Jianyong Zhuo, Xuyong Wei, Penghong Song, Lin Zhou, Xiao Xu and Shusen Zheng
    Citation: Journal of Hematology & Oncology 2017 10:59
    Content type: Research Published on:

  38. Extracellular vesicles (EVs) are small membranous vesicles secreted from numerous cell types and have been found involved in cell-to-cell communication by transferring noncoding RNAs (ncRNAs) including microRN...

    Authors: Pei Ma, Yutian Pan, Wei Li, Chongqi Sun, Jie Liu, Tongpeng Xu and Yongqian Shu
    Citation: Journal of Hematology & Oncology 2017 10:57
    Content type: Review Published on:

  39. Although blinatumomab, a bispecific T cell engaging antibody, exhibits high clinical response rates in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia (B-ALL) and B cell non-Hodgk...

    Authors: Xiaolong Zhang, Yuanyuan Yang, Leisheng Zhang, Yang Lu, Qing Zhang, Dongmei Fan, Yizhi Zhang, Yanjun Zhang, Zhou Ye and Dongsheng Xiong
    Citation: Journal of Hematology & Oncology 2017 10:56
    Content type: Research Published on:

  40. The randomized, double-blind, placebo-controlled, phase 3 COMFORT-I trial evaluated the JAK1/JAK2 inhibitor ruxolitinib in patients with intermediate-2/high-risk myelofibrosis. The primary and planned 3-year a...

    Authors: Srdan Verstovsek, Ruben A. Mesa, Jason Gotlib, Vikas Gupta, John F. DiPersio, John V. Catalano, Michael W. N. Deininger, Carole B. Miller, Richard T. Silver, Moshe Talpaz, Elliott F. Winton, Jimmie H. Harvey Jr., Murat O. Arcasoy, Elizabeth O. Hexner, Roger M. Lyons, Ronald Paquette…
    Citation: Journal of Hematology & Oncology 2017 10:55
    Content type: Research Published on:

  41. The driver mutations JAK2V617F, MPLW515L/K and CALR influence disease phenotype of myeloproliferative neoplasms (MPNs) and might sustain a condition of chronic inflammation. Pentraxin 3 (PTX3) and high-sensitivit...

    Authors: Federico Lussana, Alessandra Carobbio, Silvia Salmoiraghi, Paola Guglielmelli, Alessandro Maria Vannucchi, Barbara Bottazzi, Roberto Leone, Alberto Mantovani, Tiziano Barbui and Alessandro Rambaldi
    Citation: Journal of Hematology & Oncology 2017 10:54
    Content type: Research Published on:

  42. Chimeric antigen receptor (CAR)-engineered T cells (CAR-T cells) have yielded unprecedented efficacy in B cell malignancies, most remarkably in anti-CD19 CAR-T cells for B cell acute lymphoblastic leukemia (B-...

    Authors: Zhenguang Wang, Zhiqiang Wu, Yang Liu and Weidong Han
    Citation: Journal of Hematology & Oncology 2017 10:53
    Content type: Review Published on:

  43. Circular RNAs are a subgroup of non-coding RNAs and generated by a mammalian genome. Herein, the expression and function of circular RNA circ-TTBK2 were investigated in human glioma cells.

    Authors: Jian Zheng, Xiaobai Liu, Yixue Xue, Wei Gong, Jun Ma, Zhuo Xi, Zhongyou Que and Yunhui Liu
    Citation: Journal of Hematology & Oncology 2017 10:52
    Content type: Research Published on:

  44. The majority of individuals with acute myeloid leukemia (AML) respond to initial chemotherapy and achieve a complete remission, yet only a minority experience long-term survival because a large proportion of p...

    Authors: Hubert Hackl, Ksenia Astanina and Rotraud Wieser
    Citation: Journal of Hematology & Oncology 2017 10:51
    Content type: Review Published on:

  45. Paxilllin is a multifunctional and multidomain focal adhesion adapter protein which serves an important scaffolding role at focal adhesions by recruiting structural and signaling molecules involved in cell mov...

    Authors: Ana María López-Colomé, Irene Lee-Rivera, Regina Benavides-Hidalgo and Edith López
    Citation: Journal of Hematology & Oncology 2017 10:50
    Content type: Review Published on:

  47. Long noncoding RNAs (lncRNAs) have emerged as important regulators of tumorigenesis and cancer progression. Recently, the lncRNA AGAP2-AS1 was identified as an oncogenic lncRNA in human non-small cell lung can...

    Authors: Fuzhen Qi, Xianghua Liu, Hao Wu, Xiang Yu, Chenchen Wei, Xiaodan Huang, Guozhong Ji, Fengqi Nie and Keming Wang
    Citation: Journal of Hematology & Oncology 2017 10:48
    Content type: Research Published on:

  48. Many recent publications highlight the large role of the pivotal eukaryotic nuclear export protein exportin-1 (XPO1) in the oncogenesis of several malignancies, and there is emerging evidence that XPO1 inhibit...

    Authors: Vincent Camus, Hadjer Miloudi, Antoine Taly, Brigitte Sola and Fabrice Jardin
    Citation: Journal of Hematology & Oncology 2017 10:47
    Content type: Review Published on:

  49. Immune thrombocytopenia (ITP) is a common autoimmune bleeding disorder. Despite considerable investigation, the pathogenesis of ITP remains incompletely understood, and for many patients, effective therapy is ...

    Authors: Lili Tao, Qingshu Zeng, June Li, Miao Xu, Jiajia Wang, Ying Pan, Huiping Wang, Qianshan Tao, Yang Chen, Jun Peng, Ming Hou, Arend Jan Gerard Jansen, Heyu Ni and Zhimin Zhai
    Citation: Journal of Hematology & Oncology 2017 10:46
    Content type: Letter to the Editor Published on:

  50. Previous precision medicine studies have investigated conventional molecular techniques and/or limited sets of gene alterations. The aim of this study was to describe the impact of the next-generation sequenci...

    Authors: Sophie Cousin, Thomas Grellety, Maud Toulmonde, Céline Auzanneau, Emmanuel Khalifa, Yec’han Laizet, Kevin Tran, Sylvestre Le Moulec, Anne Floquet, Delphine Garbay, Jacques Robert, Isabelle Hostein, Isabelle Soubeyran and Antoine Italiano
    Citation: Journal of Hematology & Oncology 2017 10:45
    Content type: Letter to the Editor Published on:
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Journal of Hematology & Oncology

ISSN: 1756-8722

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