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  1. A previous study has demonstrated a significantly increased CD3ζ gene expression level in aplastic anemia (AA). However, the mechanism underlying the upregulated CD3ζ mRNA expression level and that of T cell a...

    Authors: Bo Li, Lixing Guo, Yuping Zhang, Yankai Xiao, Mingjuan Wu, Lingling Zhou, Shaohua Chen, Lijian Yang, Xiang Lu and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2016 9:32
    Content type: Research Published on:

  2. Hematologic malignancies arising in the setting of established germ cell tumors have been previously described and have a dismal prognosis. Identification of targetable mutations and pathway dysregulation thro...

    Authors: Jessica T. Leonard, Philipp W. Raess, Jennifer Dunlap, Brandon Hayes-Lattin, Jeffrey W. Tyner and Elie Traer
    Citation: Journal of Hematology & Oncology 2016 9:31
    Content type: Case report Published on:

  3. The t(11;14) translocation resulting in constitutive cyclin D1 expression is an early event in mantle cell lymphoma (MCL) transformation. Patients with a highly proliferative phenotype produce cyclin D1 transc...

    Authors: Chioniso Patience Masamha, Todd R. Albrecht and Eric J. Wagner
    Citation: Journal of Hematology & Oncology 2016 9:30
    Content type: Letter to the Editor Published on:

  4. Anti-programmed death-1 therapy has poor efficacy in mismatch repair-proficient (pMMR) colorectal cancers; however, its efficacy in pMMR gastric cancers remains undetermined. Here, we report the case of a pati...

    Authors: Kuo-Hsing Chen, Chang-Tsu Yuan, Li-Hui Tseng, Chia-Tung Shun and Kun-Huei Yeh
    Citation: Journal of Hematology & Oncology 2016 9:29
    Content type: Case report Published on:

  5. Recent population-based studies in the United States of America (USA) and other countries have shown improvements in survival for patients with chronic lymphocytic leukemia (CLL) diagnosed in the early twenty-...

    Authors: Dianne Pulte, Felipe A. Castro, Lina Jansen, Sabine Luttmann, Bernd Holleczek, Alice Nennecke, Meike Ressing, Alexander Katalinic and Hermann Brenner
    Citation: Journal of Hematology & Oncology 2016 9:28
    Content type: Research Published on:

  6. Juvenile myelomonocytic leukemia (JMML) is a fatal, myelodysplastic/myeloproliferative neoplasm of early childhood. Patients with JMML have mutually exclusive genetic abnormalities in granulocyte-macrophage co...

    Authors: Yozo Nakazawa, Kazuyuki Matsuda, Takashi Kurata, Akane Sueki, Miyuki Tanaka, Kazuo Sakashita, Chihaya Imai, Matthew H. Wilson and Kenichi Koike
    Citation: Journal of Hematology & Oncology 2016 9:27
    Content type: Research Published on:

  7. Interim positron emission tomography after 2 cycles of ABVD (iPET-2) is a good predictor of outcome in advanced-stage classic Hodgkin lymphoma. So far, there are no other prognostic biomarkers capable of ident...

    Authors: Giorgio La Nasa, Marianna Greco, Roberto Littera, Sara Oppi, Ivana Celeghini, Rossella Caria, Sara Lai, Rita Porcella, Massimo Martino, Alessandra Romano, Francesco Di Raimondo, Andrea Gallamini, Carlo Carcassi and Giovanni Caocci
    Citation: Journal of Hematology & Oncology 2016 9:26
    Content type: Rapid communication Published on:

  8. Increasing numbers of patients are receiving haplo-identical stem cell transplantation (haplo-SCT) for treatment of acute leukemia with reduced intensity (RIC) or myeloablative (MAC) conditioning regimens. The...

    Authors: Marie T. Rubio, Bipin N. Savani, Myriam Labopin, Simona Piemontese, Emmanuelle Polge, Fabio Ciceri, Andrea Bacigalupo, William Arcese, Yener Koc, Dietrich Beelen, Zafer Gülbas, Depei Wu, Stella Santarone, Johanna Tischer, Boris Afanasyev, Christoph Schmid…
    Citation: Journal of Hematology & Oncology 2016 9:25
    Content type: Research Published on:

  9. Mixed lineage leukemia (MLL) gene translocations are found in ~75 % infant and 10 % adult acute leukemia, showing a poor prognosis. Lysine-specific demethylase 1 (LSD1) has recently been implicated to be a dru...

    Authors: Zizhen Feng, Yuan Yao, Chao Zhou, Fengju Chen, Fangrui Wu, Liping Wei, Wei Liu, Shuo Dong, Michele Redell, Qianxing Mo and Yongcheng Song
    Citation: Journal of Hematology & Oncology 2016 9:24
    Content type: Research Published on:

  10. ASP3026 is a second-generation anaplastic lymphoma kinase (ALK) inhibitor that has potent in vitro activity against crizotinib-resistant ALK-positive tumors. This open-label, multicenter, first-in-human phase I s...

    Authors: Tianhong Li, Patricia LoRusso, Michael L. Maitland, Sai-Hong Ignatius Ou, Erkut Bahceci, Howard A. Ball, Jung Wook Park, Geoffrey Yuen and Anthony Tolcher
    Citation: Journal of Hematology & Oncology 2016 9:23
    Content type: Research Published on:

  11. Achievement of durable responses in patients with relapsed/refractory peripheral T cell lymphoma (PTCL) is challenging with current therapies, and there are few data regarding the potential benefits of continu...

    Authors: Francine Foss, Steven Horwitz, Barbara Pro, H. Miles Prince, Lubomir Sokol, Barbara Balser, Julie Wolfson and Bertrand Coiffier
    Citation: Journal of Hematology & Oncology 2016 9:22
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Hematology & Oncology 2017 10:154

  13. Sorafenib is recognized as a standard treatment for advanced hepatocellular carcinoma (HCC). However, many patients have to adopt dose reduction or terminate the use of sorafenib because of side effects. In ad...

    Authors: Abin You, Manqing Cao, Zhigui Guo, Bingfeng Zuo, Junrong Gao, Hongyuan Zhou, Huikai Li, Yunlong Cui, Feng Fang, Wei Zhang, Tianqiang Song, Qiang Li, Xiaolin Zhu, Haifang Yin, Huichuan Sun and Ti Zhang
    Citation: Journal of Hematology & Oncology 2016 9:20
    Content type: Research Published on:

  15. Patients with Ph-negative myeloproliferative neoplasms (MPN), such as polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are at increased risk for thrombosis/thromboemboli...

    Authors: A. Kaifie, M. Kirschner, D. Wolf, C. Maintz, M. Hänel, N. Gattermann, E. Gökkurt, U. Platzbecker, W. Hollburg, J. R. Göthert, S. Parmentier, F. Lang, R. Hansen, S. Isfort, K. Schmitt, E. Jost…
    Citation: Journal of Hematology & Oncology 2016 9:18
    Content type: Research Published on:

  16. The polycomb complex protein BMI-1 (BMI-1) is a putative oncogene reported to be overexpressed in multiple myeloma (MM). Silencing of BMI-1 was shown to impair the growth and survival of MM cells. However, the...

    Authors: Arnold Bolomsky, Karin Schlangen, Wolfgang Schreiner, Niklas Zojer and Heinz Ludwig
    Citation: Journal of Hematology & Oncology 2016 9:17
    Content type: Research Published on:

  19. Non-small cell lung cancer (NSCLC) causes considerable mortality in the world. Owing to molecular biological progress, treatments in adenocarcinoma have evolved revolutionarily while those in squamous lung can...

    Authors: Yijun Tian, Qian Liu, Xuelian He, Xun Yuan, Yuan Chen, Qian Chu and Kongming Wu
    Citation: Journal of Hematology & Oncology 2016 9:14
    Content type: Review Published on:

  20. Our previous pilot studies aimed to examine the role of hydrogen sulfide (H2S) in the generation of endothelial progenitor cells led to an unexpected result, i.e., H2S promoted the differentiation of certain hema...

    Authors: Huan-Di Liu, Ai-Jie Zhang, Jing-Jing Xu, Ying Chen and Yi-Chun Zhu
    Citation: Journal of Hematology & Oncology 2016 9:13
    Content type: Research Published on:

  21. Acute lymphoblastic leukemia (ALL) is an aggressive malignant disorder of lymphoid progenitor cells in both children and adults. Although improvements in contemporary therapy and development of new treatment s...

    Authors: Pei-Jie Shi, Lu-Hong Xu, Kang-Yu Lin, Wen-jun Weng and Jian-Pei Fang
    Citation: Journal of Hematology & Oncology 2016 9:12
    Content type: Research Published on:

  23. Cancer is currently one of the leading causes of death worldwide and is one of the most challenging major public health problems. The main challenges faced by clinicians in the management and treatment of canc...

    Authors: Zhenbo Tu, Ruijing Xiao, Jie Xiong, Kingsley M. Tembo, Xinzhou Deng, Meng Xiong, Pan Liu, Meng Wang and Qiuping Zhang
    Citation: Journal of Hematology & Oncology 2016 9:10
    Content type: Review Published on:

  24. We herein report the first case of X-linked agammaglobulinemia (XLA) that underwent allogeneic stem cell transplantation using reduced intensity conditioning (RIC). We chronologically observed the reconstituti...

    Authors: Kazuhiro Ikegame, Kohsuke Imai, Motoi Yamashita, Akihiro Hoshino, Hirokazu Kanegane, Tomohiro Morio, Katsuji Kaida, Takayuki Inoue, Toshihiro Soma, Hiroya Tamaki, Masaya Okada and Hiroyasu Ogawa
    Citation: Journal of Hematology & Oncology 2016 9:9
    Content type: Case report Published on:

  25. Cancer-associated fibroblasts (CAFs) are believed to play an essential role in cancer initiation and development. However, little research has been undertaken to evaluate the role of CAFs in endometrial cancer...

    Authors: Fei Teng, Wen-Yan Tian, Ying-Mei Wang, Yan-Fang Zhang, Fei Guo, Jing Zhao, Chao Gao and Feng-Xia Xue
    Citation: Journal of Hematology & Oncology 2016 9:8
    Content type: Research Published on:

  27. Advanced pancreatic cancer (PC) has very poor prognosis with present treatments, thus necessitating continued efforts to find improved therapeutic approaches. Both preclinical and preliminary clinical data ind...

    Authors: Zibing Wang, Yuqing Liu, Rui’e Li, Yiman Shang, Yong Zhang, Lingdi Zhao, Wei Li, Yonghao Yang, Xiaojie Zhang, Tiejun Yang, Changfu Nie, Feng Han, Ying Liu, Suxia Luo, Quanli Gao and Yongping Song
    Citation: Journal of Hematology & Oncology 2016 9:6
    Content type: Research Published on:

  28. In spite of the recent discovery of genetic mutations in most myelodysplasic (MDS) patients, the pathophysiology of these disorders still remains poorly understood, and only few in vivo models are available to...

    Authors: Laura Guerenne, Stéphanie Beurlet, Mohamed Said, Petra Gorombei, Carole Le Pogam, Fabien Guidez, Pierre de la Grange, Nader Omidvar, Valérie Vanneaux, Ken Mills, Ghulam J Mufti, Laure Sarda-Mantel, Maria Elena Noguera, Marika Pla, Pierre Fenaux, Rose Ann Padua…
    Citation: Journal of Hematology & Oncology 2016 9:5
    Content type: Research Published on:

  29. Bone marrow (BM) niches are often inaccessible for controlled experimentation due to their difficult accessibility, biological complexity, and three-dimensional (3D) geometry.

    Authors: Mónica S. Ventura Ferreira, Christian Bergmann, Isabelle Bodensiek, Kristina Peukert, Jessica Abert, Rafael Kramann, Paul Kachel, Björn Rath, Stephan Rütten, Ruth Knuchel, Benjamin L. Ebert, Horst Fischer, Tim H. Brümmendorf and Rebekka K. Schneider
    Citation: Journal of Hematology & Oncology 2016 9:4
    Content type: Research Published on:

  30. Hypoacetylation on histone H3 of human prostate cancer cells has been described. Little is known about the modifications of other histones from prostate cancer cells.

    Authors: Shundong Cang, Xiaobin Xu, Yuehua Ma, Delong Liu and J. W. Chiao
    Citation: Journal of Hematology & Oncology 2016 9:3
    Content type: Letter to the Editor Published on:

  31. Activated B lymphocytes harbor programmed DNA double-strand breaks (DSBs) initiated by activation-induced deaminase (AID) and repaired by non-homologous end-joining (NHEJ). While it has been proposed that thes...

    Authors: Zhangguo Chen, Mihret T. Elos, Sawanee S. Viboolsittiseri, Katherine Gowan, Sonia M. Leach, Michael Rice, Maxwell D. Eder, Kenneth Jones and Jing H. Wang
    Citation: Journal of Hematology & Oncology 2016 9:2
    Content type: Research Published on:

  32. Our previous study reported that microRNA-26a (miR-26a) inhibited tumor progression by inhibiting tumor angiogenesis and intratumoral macrophage infiltration in hepatocellular carcinoma (HCC). The direct roles...

    Authors: De-Ning Ma, Zong-Tao Chai, Xiao-Dong Zhu, Ning Zhang, Di-Hua Zhan, Bo-Gen Ye, Cheng-Hao Wang, Cheng-Dong Qin, Yi-Ming Zhao, Wei-Ping Zhu, Man-Qing Cao, Dong-Mei Gao, Hui-Chuan Sun and Zhao-You Tang
    Citation: Journal of Hematology & Oncology 2016 9:1
    Content type: Research Published on:

  33. We have previously shown that palmitoylation is essential for NRAS leukemogenesis, suggesting that targeting RAS palmitoylation may be an effective therapy for NRAS-related cancers. For KRAS-driven cancer, alt...

    Authors: Huanbin Zhao, Ping Liu, Ruihong Zhang, Min Wu, Donghe Li, Xuemei Zhao, Chun Zhang, Bo Jiao, Bing Chen, Zhu Chen and Ruibao Ren
    Citation: Journal of Hematology & Oncology 2015 8:132
    Content type: Research Published on:

  35. Bispecific antibodies (BsAbs) recognize two different epitopes. This dual specificity opens up a wide range of applications, including redirecting T cells to tumor cells, blocking two different signaling pathw...

    Authors: Gaowei Fan, Zujian Wang, Mingju Hao and Jinming Li
    Citation: Journal of Hematology & Oncology 2015 8:130
    Content type: Review Published on:

  36. With the advent of new agents targeting CD20, Bruton’s tyrosine kinase, and phosphoinositol-3 kinase for chronic lymphoid leukemia (CLL), more treatment options exist than ever before. B-cell lymphoma-2 (BCL-2...

    Authors: Shundong Cang, Chaitanya Iragavarapu, John Savooji, Yongping Song and Delong Liu
    Citation: Journal of Hematology & Oncology 2015 8:129
    Content type: Review Published on:

  38. EGFR mutation is a strong predictor of efficacy of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKIs) therapy in advanced non-small cell lung cancer (NSCLC). Howeve...

    Authors: Shuhang Wang, Xiaomei Su, Hua Bai, Jun Zhao, Jianchun Duan, Tongtong An, Minglei Zhuo, Zhijie Wang, Meina Wu, Zhenxiang Li, Jian Zhu and Jie Wang
    Citation: Journal of Hematology & Oncology 2015 8:127
    Content type: Research Published on:

  39. Acute promyelocytic leukemia (APL) is associated with chromosomal translocation t(15;17), which results in the proliferation of morphologically abnormal promyelocytes. Gain of supernumerary copies of the 8q24 ...

    Authors: Chengwu Zeng, Xibao Yu, Jing Lai, Lijiang Yang, Shaohua Chen and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2015 8:126
    Content type: Rapid communication Published on:

  40. Although progress in children, in adults, ALL still carries a dismal outcome. Here, we explored the in vitro and in vivo activity of PF-00477736 (Pfizer), a potent, selective ATP-competitive small-molecule inh...

    Authors: Ilaria Iacobucci, Andrea Ghelli Luserna Di Rorà, Maria Vittoria Verga Falzacappa, Claudio Agostinelli, Enrico Derenzini, Anna Ferrari, Cristina Papayannidis, Annalisa Lonetti, Simona Righi, Enrica Imbrogno, Silvia Pomella, Claudia Venturi, Viviana Guadagnuolo, Federica Cattina, Emanuela Ottaviani, Maria Chiara Abbenante…
    Citation: Journal of Hematology & Oncology 2015 8:125
    Content type: Research Published on:

  42. Advanced melanoma has historically been a difficult disease to treat due to few effective systemic treatment options. However, over the past few years, scientific advancements in immune checkpoint inhibition h...

    Authors: Katy K. Tsai and Adil I. Daud
    Citation: Journal of Hematology & Oncology 2015 8:123
    Content type: Commentary Published on:

  43. Hepatocellular carcinoma (HCC) displays high resistance to conventional chemotherapy. Considering that microRNA-122 (miR-122) performs an essential function to promote chemosensitivity of HCC cells, an effecti...

    Authors: Guohua Lou, Xiuli Song, Fan Yang, Shanshan Wu, Jing Wang, Zhi Chen and Yanning Liu
    Citation: Journal of Hematology & Oncology 2015 8:122
    Content type: Research Published on:

  44. Diffuse large B cell lymphoma (DLBCL) is the most common type of lymphoid malignancy worldwide. Approximately 5 % of cases of DLBCL are so-called double-hit lymphomas (DHL), defined by a chromosomal translocat...

    Authors: Lan V. Pham, Gary Lu, Archito T. Tamayo, Juan Chen, Pramoda Challagundla, Jeffrey L. Jorgensen, L. Jeffrey Medeiros and Richard J. Ford
    Citation: Journal of Hematology & Oncology 2015 8:121
    Content type: Research Published on:

  45. Nemo-like kinase (NLK) is an evolutionarily conserved serine/threonine kinase that regulates the activity of a wide range of signal transduction pathways. Metformin, an oral antidiabetic drug, is used for canc...

    Authors: Dong Suwei, Zeng Liang, Liu Zhimin, Li Ruilei, Zou Yingying, Li Zhen, Ge Chunlei, Lai Zhangchao, Xue Yuanbo, Yang Jinyan, Li Gaofeng and Song Xin
    Citation: Journal of Hematology & Oncology 2015 8:120
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Hematology & Oncology 2016 9:11

  46. Urothelial cancers (UC) are the fourth most common tumours worldwide after prostate (or breast), lung and colorectal cancer. Despite recent improvements in their management, UC remain an aggressive disease ass...

    Authors: Alejo Rodriguez-Vida, Matilde Saggese, Simon Hughes, Sarah Rudman, Simon Chowdhury, Neil R. Smith, Peter Lawrence, Claire Rooney, Brian Dougherty, Donal Landers, Elaine Kilgour and Hendrik-Tobias Arkenau
    Citation: Journal of Hematology & Oncology 2015 8:119
    Content type: Case report Published on:

  47. This report focuses on the adaptive phase I trial design aimed to find the clinically applicable dose for decitabine maintenance treatment after allogeneic hematopoietic stem cell transplantation in patients w...

    Authors: Seunghoon Han, Yoo-Jin Kim, Jongtae Lee, Sangil Jeon, Taegon Hong, Gab-jin Park, Jae-Ho Yoon, Seung-Ah Yahng, Seung-Hwan Shin, Sung-Eun Lee, Ki-Seong Eom, Hee-Je Kim, Chang-Ki Min, Seok Lee and Dong-Seok Yim
    Citation: Journal of Hematology & Oncology 2015 8:118
    Content type: Research Published on:

  48. HTLV-I is associated with the development of an aggressive form of lymphocytic leukemia known as adult T-cell leukemia/lymphoma (ATLL). A major obstacle for effective treatment of ATLL resides in the genetic d...

    Authors: Xue Tao Bai, Ramona Moles, Hassiba Chaib-Mezrag and Christophe Nicot
    Citation: Journal of Hematology & Oncology 2015 8:117
    Content type: Research Published on:

  49. Prolonged isolated thrombocytopenia (PT) is a frequent complication in patients who undergo allogeneic hematopoietic stem cell transplantation (allo-HSCT), and it is associated with an adverse prognosis. In th...

    Authors: Xiao-Hui Zhang, Qian-Ming Wang, Jia-Min Zhang, Fei-Er Feng, Feng-Rong Wang, Huan Chen, Yuan-Yuan Zhang, Yu-Hong Chen, Wei Han, Lan-Ping Xu, Kai-Yan Liu and Xiao-Jun Huang
    Citation: Journal of Hematology & Oncology 2015 8:116
    Content type: Research Published on:

  50. Therapy and outcome for elderly acute myeloid leukemia (AML) patients has not improved for many years. Similarly, there remains a clinical need to improve response rates in advanced myelodysplastic syndrome (M...

    Authors: Raoul Tibes, Aref Al-Kali, Gavin R Oliver, Devora H Delman, Nanna Hansen, Keerthi Bhagavatula, Jayaram Mohan, Fariborz Rakhshan, Thomas Wood, James M. Foran, Ruben A. Mesa and James M. Bogenberger
    Citation: Journal of Hematology & Oncology 2015 8:114
    Content type: Research Published on:
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Journal of Hematology & Oncology

ISSN: 1756-8722

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