- Case report
- Open Access
An unusual presentation of precursor T cell lymphoblastic leukemia/lymphoma with cholestatic jaundice: case report
© Patel et al; licensee BioMed Central Ltd. 2009
Received: 12 January 2009
Accepted: 12 March 2009
Published: 12 March 2009
Cholestatic jaundice as a presenting symptom of Precursor T-lymphoblastic leukemia (T-ALL)/lymphoma (T-LBL) has never been reported in literature. Similarly, precursor T-ALL/T-LBL is characteristically negative for synaptophysin. We report the first case of a patient with precursor T-ALL/T-LBL who presented with cholestatic jaundice and aberrant tumor expression of synaptophysin.
42 year old male presented with anorexia, nausea, jaundice, pale stools, dark urine and about 35 pound weight loss over the previous 3 weeks. The initial laboratory work was suggestive of cholestatic jaundice. Markedly elevated LDH (2025 U/L) and CA 19-9 (1778 u/ML) were also noticed. The CT scan of abdomen showed massive hepatomegaly with coarse echotexture with contracted gall bladder and normal sized common bile duct. Chest x-ray revealed a mediastinal mass with mediastinal widening. CT scan of the chest showed anterior mediastinal mass (16 cm × 10 cm). CT guided biopsy of the mass showed malignant lymphoma with diffuse proliferation of medium sized lymphoid cells. The neoplastic cells were positive for CD1a, CD3, CD4, CD5, CD8 and CD43 with aberrant expression of synaptophysin. PET CT scan again showed a large anterior mediastinal mass with diffuse liver involvement and abnormal activity in axial bones. CT guided liver biopsy and bone marrow biopsy revealed the same morphology and immunohistochemistry. Bone marrow aspirate showed 85% lymphoblasts. Thus, the diagnosis of precursor T-ALL/T-LBL was made and jaundice with elevated CA 19-9 were attributed to intrahepatic cholestasis.
Our case illustrates an unusual presentation of hematological malignancies as cholestatic jaundice. It also indicates the non-specific nature of CA 19-9 for pancreaticobiliary malignancies. It is the first case report of neoplastic precursor T cell lymphoblasts with unusual expression of synaptophysin. Tissue biopsy with thorough immunohistochemistry is required to differentiate precursor T-ALL/T-LBL from thymoma and small cell carcinoma.
Precursor T-lymphoblastic leukemia (T-ALL)/lymphoma (T-LBL) is a neoplasm of lymphoblasts committed to the T-cell lineage. Clinically, if there are >25 percent bone marrow blasts with or without a mass lesion, the term precursor T-ALL is used. The term precursor T-LBL is used, if there is a mass lesion with less than 25 percent bone marrow involvement . However, due to their biologic unity and significant clinical overlap, T-ALL and T-LBL are considered the same disease with different clinical presentations . Our case highlights two unusual manifestations of precursor T-ALL/T-LBL, namely, the rare initial presentation of cholestatic jaundice and the aberrant expression of synaptophysin by the tumor cells both of which, to the best of our knowledge, have not been reported before.
42 year old obese (BMI-38) caucasian male presented to his primary care provider with complaints of insidious onset of anorexia, nausea, jaundice, pale stools, dark urine and about 35 pound weight loss over the previous 3 weeks. Outpatient laboratory work up revealed normal complete blood counts and basic panel but deranged liver function tests suggestive of cholestatic jaundice. Patient was then referred to a regional medical center for imaging studies. Ultrasound of abdomen showed multiple hyperechoic and hypoechoic liver lesions all less than 1 cm in size. The CT scan of abdomen showed massive hepatomegaly with coarse echotexture with contracted gall bladder and normal sized common bile duct. A chest x-ray (Figure 1A) obtained at the same time revealed a huge mediastinal mass with evidence of mediastinal widening. CT scan of the chest (Figure 1B) showed 3 anterior mediastinal masses with the largest one being 16 cm × 10 cm. In view of these imaging studies, the patient was referred to a tertiary care center for further work up. Upon arrival, we found the patient to be significantly icteric with some abdominal distension. There was smooth, non-tender liver edge palpable 10 cm below the right costal margin. No peripheral lymphadenopathy was noticed. The laboratory work on admission showed normal CBC and basic panel but persistently deranged liver function tests (Table 1).
showing results of laboratory workup on admission at the tertiary care center (Day 0), during hospitalization (Day 7) and on outpatient follow up (day 100).
On Day 7
(1 day before
(after 3 cy of CD
100 and 3 cy of
Cholestatic jaundice as an initial presentation of acute lymphoblastic leukemia (ALL) is exceedingly rare [3, 4]. A histopathological study of liver from autopsies of untreated patients diagnosed with leukemia or lymphoma did not reveal any evidence of cholestasis . Majority of the cases reported describe cholestatic jaundice due to extrahepatic bile duct obstruction as a presenting feature of acute leukemia [6, 7] Whereas Kelleher et al have reported intrahepatic cholestasis as initial presentation of precursor B-ALL in two children ; our literature search did not reveal any case of intrahepatic cholestasis in association with precursor T-ALL/T-LBL. We report the first case of a patient with precursor T-ALL/T-LBL who presented with intrahepatic cholestasis.
This patient had presented with painless jaundice, pale stools, direct hyperbilirubinemia, non-dilated common bile duct and multiple liver lesions suggestive of intrahepatic cholestasis. The significantly elevated serum CA 19-9 level was later attributed to the cholestatic jaundice rather than primary hepatobiliary and pancreatic malignancies . This represents the nonspecific nature of this tumor marker .
This patient had a bulky anterior mediastinal mass. Masses in the anterior compartment are more likely to be malignant than those found in the other mediastinal compartments . Thymomas are the most common anterior mediastinal primary neoplasms in adults . Symptoms due to myasthenia gravis or other tumor-related syndromes are present in 35 percent of patients with thymoma at diagnosis . Small cell lung cancer presents most commonly as a large hilar mass with bulky mediastinal adenopathy. Therefore, tissue biopsy with thorough immunohistochemical analysis is important to differentiate between thymomas, small cell lung cancers and lymphomas. Thymomas are composed of a mixture of neoplastic epithelial cells and non-neoplastic T lymphocytes, small cell carcinomas are characterized by small "blue" malignant cells about twice the size of lymphocytes, whereas T cell Lymphomas are composed of neoplastic T lymphocytes. The tumor cells in this patient were cytokeratin negative indicating their non-epithelial origin and thus, making the diagnosis of thymoma unlikely. These cells were also negative for most of the neural and neuroendocrine markers except for synaptophysin. This helped rule out small cell carcinoma. Further, these cells were positive for CD1a, sCD3, CD4/CD8 double positive indicating that neoplastic cells were in fact T cell lymphoblasts  more specifically, the common thyomocytes which represent an intermediate intrathymic maturation stage for T lymphoblasts. The lack of tumor cell expression of CD34 and TdT markers, as seen in this patient, is more common in precursor T-ALL than in precursor B-ALL . Thus, tissue biopsy with thorough immunohistochemistry is required to differentiate T-ALL from thymoma and small cell carcinoma.
It was, however, unusual that these T cell lymphoblasts had aberrant expression of synaptophysin, an immunocytochemical marker for neuroendocrine differentiation (Figure 2C). Our literature search did not reveal synaptophysin positivity in any case of lymphoma or leukemia. Whether this aberrant expression of synaptophysin in precursor T-ALL/T-LBL carries any prognostic significance remains to be evaluated.
To our knowledge, this is the first case report of precursor T-ALL/T-LBL presenting as cholestatic jaundice in an adult and also of neoplastic precursor T cell lymphoblasts expressing synaptophysin. It also indicates the non-specific nature of CA 19-9 for pancreaticobiliary malignancies. Tissue biopsy with thorough immunohistochemistry is required to differentiate precursor T-ALL/T-LBL from thymoma and small cell carcinoma.
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Harris NL, Jaffe ES, Diebold J: WHO classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting- Airlie House, Virginia, Nov 1997. J Clin Oncol. 1999, 17: 3835-3849.PubMedGoogle Scholar
- Jaffe ES, Harris NL, Stein H, Vardiman JW, Eds: World Health Organization classification of tumours. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. 2001, IARC Press: LyonGoogle Scholar
- Devictor D, Tashive C, Fagre M: Early pre-B acute leukemia presenting as fulminant liver failure. J Pediatr Gastroenterol Nutr. 1996, 22 (1): 103-6. 10.1097/00005176-199601000-00017.View ArticlePubMedGoogle Scholar
- Mori T, Sugita K, Suzuki T: Histopathologic features of the biopsied liver at the onset of childhood B-precursor acute lymphoblastic leukemia presenting as severe jaundice. J Pediatr Gastroenterol. 1997, 25: 354-357. 10.1097/00005176-199709000-00021.View ArticleGoogle Scholar
- Scheinberg IB, Pollock DJ, Collins PW: Pathology of the liver in leukemia and lymphoma. A study of 110 autopsies. Histopathology. 1995, 26: 311-321. 10.1111/j.1365-2559.1995.tb00192.x.View ArticleGoogle Scholar
- Alvaro F, Jain M, Morris LL: Childhood acute lymphoblastic leukemia presenting as jaundice. J Pediatr Child Health. 1996, 32 (5): 466-468. 10.1111/j.1440-1754.1996.tb00951.x.View ArticleGoogle Scholar
- Goor Y, Goor O, Michalewitcz R: Acute myeloid leukemia presenting as obstructive jaundice. J Clin Gastroenterol. 2002, 34 (4): 485-486. 10.1097/00004836-200204000-00023.View ArticlePubMedGoogle Scholar
- Kelleher JF, Monteleone PM, Steele DA: Hepatic Dysfunction as the Presenting Feature of Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2001, 23 (2): 117-121. 10.1097/00043426-200102000-00010.View ArticlePubMedGoogle Scholar
- Kim HJ, Kim MH, Myung SJ: A new strategy for the application of CA19-9 in the differentiation of pancreaticobiliary cancer: analysis using a receiver operating characteristic curve. Am J Gastroenterol. 1999, 94 (7): 1941-1946. 10.1111/j.1572-0241.1999.01234.x.View ArticlePubMedGoogle Scholar
- Davis RD, Oldham HN, Sabiston DC: Primary cysts and neoplasms of the mediastinum: recent changes in clinical presentation, methods of diagnosis, management, and results. Ann Thorac Surg. 1987, 44 (3): 229-237.View ArticlePubMedGoogle Scholar
- Lewis JE, Wick MR, Scheithauer BW: Thymoma. A clinicopathologic review. Cancer. 1987, 60 (11): 2727-2743. 10.1002/1097-0142(19871201)60:11<2727::AID-CNCR2820601125>3.0.CO;2-D.View ArticlePubMedGoogle Scholar
- DiGiuseppe JA: Acute Lymphoblastic Leukemia: Diagnosis and Detection of Minimal Residual Disease Following Therapy. Clin Lab Med. 2007, 27: 533-549. 10.1016/j.cll.2007.05.005.View ArticlePubMedGoogle Scholar
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