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Expert consensus on multidisciplinary therapy of colorectal cancer with lung metastases (2019 edition)
Journal of Hematology & Oncologyvolume 12, Article number: 16 (2019)
The lungs are the second most common site of metastasis for colorectal cancer (CRC) after the liver. Rectal cancer is associated with a higher incidence of lung metastases compared to colon cancer. In China, the proportion of rectal cancer cases is around 50%, much higher than that in Western countries (nearly 30%). However, there is no available consensus or guideline focusing on CRC with lung metastases. We conducted an extensive discussion and reached a consensus of management for lung metastases in CRC based on current research reports and the experts’ clinical experiences and knowledge. This consensus provided detailed approaches of diagnosis and differential diagnosis and provided general guidelines for multidisciplinary therapy (MDT) of lung metastases. We also focused on recommendations of MDT management of synchronous lung metastases and initial metachronous lung metastases. This consensus might improve clinical practice of CRC with lung metastases in China and will encourage oncologists to conduct more clinical trials to obtain high-level evidences about managing lung metastases.
Overview and epidemiology of lung metastases in colorectal cancer
The incidence of colorectal cancer (CRC) continues to increase each year. In 2015, the incidence and mortality of CRC is ranked fifth among all malignant tumors in China . In recent years, the widespread use of chest CT scans has resulted in a continuous increase in the number of CRC patients who are diagnosed with lung metastases. Retrospective data from 1996 to 2017 from Peking University Cancer Hospital show that lung metastases accounted for 32.9% of all metastatic CRCs (mCRC) and the tumors in 24.5% of mCRC patients first metastasized to the lung . Currently, the lungs are the second most common site of metastasis for CRC after the liver. As patients with rectal cancer are prone to lung metastases [3, 4] and the proportion of rectal cancer cases in China (nearly 50%) is significantly higher than in Western countries (around 30%) [5,6,7,8], the diagnosis and treatment of lung metastases in CRC are more significant clinical problems in China.
Compared to other distal metastases, lung metastases have relatively slower growth and better overall survival . Therefore, the treatment strategy for lung metastases cannot be made completely according to that for metastases at other sites (e.g., liver, peritoneum). However, there are no guidelines or expert consensus for lung metastases in CRC. Therefore, the Chinese College of Surgeons Expert Committee on Multidisciplinary Therapy and The Committee of Colorectal Cancer of the China Anti-Cancer Association have conducted an extensive discussion and reached a consensus for the recommendation of the multidisciplinary management for lung metastases in CRC.
Lung metastases can be classified into synchronous metastases and metachronous metastases based on the interval between the primary tumor and lung metastases appear. This consensus considers the perspective of clinical operability and refers to the latest treatment mode for liver metastases  to define synchronous lung metastases as “lung metastases that are discovered during the diagnostic workup for the primary tumor of CRC,” whereas metachronous lung metastases are defined as “lung metastases that are found after diagnostic examinations.”
Lung metastases are classified as initial metastases and non-initial metastases according to the sequence of lung metastases and other distal metastases. Initial lung metastasis is defined as lungs being the site of the first distal metastases, regardless of whether it is accompanied by other distal metastases. This includes all synchronous lung metastases and initial metachronous lung metastases (lung metastases that appear during preoperative neoadjuvant therapy or after resection of the primary lesion) and accounts for 74.4% of all lung metastases . These metastases are the primary focus of discussion in this consensus. In contrast, non-initial lung metastases are developed during treatment for other metastatic diseases so they are all metachronous metastases.
Lung metastases can be classified as isolated lung metastases and non-isolated lung metastases depending on whether it is accompanied by extrapulmonary metastases (see Additional file 1).
Among patients with initial lung metastases, 37.7–44.5% have isolated lung metastases, of which only 21.1–32.5% of patients can undergo radical surgery for lung metastases [2, 11]. The remaining patients with isolated lung metastases have no opportunity to undergo radical treatment. For this population, there is a great uncertainty on the selection of systemic therapy, whether other local treatments of lung metastases can be conducted, and how to manage the primary CRC lesions. Among patients with non-isolated lung metastases, 38.6–55.5% have comorbid liver metastases [2, 11], of which most patients cannot receive radical treatment of all metastatic lesions. Is there survival benefit if local treatment is conducted on the primary lesions and/or liver metastases? This consensus provides recommendations for clinical diagnosis and treatment decisions for the aforementioned problems. In addition, this consensus also discusses some specific problems related to non-initial lung metastases such as the management of lung metastases after resection of liver metastases.
Diagnosis and differential diagnosis of lung metastases in CRC
Unless lymphangitic carcinomatosis or extensive pleural metastases occur, CRC patients with lung metastases usually do not show respiratory signs or symptoms. Therefore, it is recommended that high-resolution chest CT scans be used, whereas other imaging methods such as chest X-rays and MRI are not recommended. It is recommended that enhanced chest CT scans be used for the diagnosis of mediastinal or hilar lymph node metastases.
Risk factors supporting lung metastases diagnosis
The risk factors supporting lung metastases diagnosis are age of onset > 70 years, multiple nodules in both lungs, metachronous intrapulmonary nodules, pleural thickening or effusion, rectal cancer (particularly middle or lower rectal cancer), locally advanced CRC (particularly extramural vascular invasion), higher N stages, lymphovascular invasion at the primary lesion, elevated preoperative CEA levels, KRAS mutations in the primary lesion, and presence of liver metastases or other extrapulmonary metastases [3, 4, 12,13,14,15,16,17,18,19,20].
The signs of lymphangitic carcinomatosis are irregular or nodular thickening of peripheral vascular and tracheal bundles, interlobular septa uniform or nodular thickening with normal lobular morphology or angular changes, and regional lymph node enlargement. Other signs include diffuse intrapulmonary nodules, pleural hypertrophy, and pleural effusion.
Lung metastases in CRC should be differentiated from other malignant nodules such as primary lung cancer and benign diseases including benign non-specific nodules, infectious lesions, and immune disorders.
In pathology, CRC lung metastases appear as moderately to highly differentiated adenocarcinomas, with relatively large glandular lumen and tall epithelial cells. Primary lung adenocarcinomas mostly exhibit an acinar growth pattern with relatively small glandular lumen. The epithelial cells often appear as hobnail-like cells. Adenocarcinomas in situ showing lepidic growth are often seen nearby. For poorly differentiated metastatic colorectal adenocarcinomas and unique types of adenocarcinomas such as mucinous adenocarcinoma, signet ring cell carcinoma, and poorly differentiated primary lung adenocarcinomas, it is difficult to differentiate them by morphology, thus immunohistochemistry and detailed medical history should be used for differentiation. CRC lung metastases commonly stain positive for CK20, CDX-2, and SATB2, whereas primary lung adenocarcinomas commonly stain positive for CK7, TIF-1, and napsin A . Other neoplasms should be considered in the differentiation as well (e.g., neuroendocrine tumor, pneumocytoma, adenocystic carcinoma, myxoepithelioma).
In addition, the consensus recommends routine testing for KRAS, NRAS, and BRAF mutation, as well as status of microsatellite instability (MSI) or function of mismatch repair (MMR) proteins . Because KRAS mutation is involved in lung metastasis, the frequency of KRAS mutation in patients with lung metastases is high . It is also recommended that HER2 immunohistochemical detection be routinely conducted.
Patients with lung metastases exhibit some molecular characteristics different from the primary tumors; therefore genetic analysis of lung metastasis should be conducted when possible to better aid the oncologist in determining a treatment regimen. For patients whose tissue specimens from metastatic lesions cannot be obtained, liquid biopsy can be considered for testing of relevant genes and molecular markers . However, this strategy has not been validated by large-scale clinical studies, and the interpretation of results remains debatable.
General guidelines for multidisciplinary therapy of lung metastases in CRC
Overall, for patients with curable lung metastases, the treatment goal is to achieve the status of no evidence of disease (NED) and reduce recurrence risk, and for those with incurable disease even after intensive systemic therapy, the goal is to prolong survival duration and improve life quality. The general principle of the management of lung metastases is that comprehensive therapy should be conducted after multidisciplinary discussion, because the number, site, size, and genotype of lung metastases, primary tumor location, and extrapulmonary metastases affect prognosis and treatment decisions. Therapeutic approaches include systemic therapy, radical local treatment (e.g., R0 surgical resection, stereotactic radiation therapy, and ablation therapy), and local palliative treatment. Multidisciplinary discussion should combine the patient’s clinical characteristics with accessibility to medical resources to determine treatment goals and thereby formulate a rational and orderly comprehensive treatment strategy (Fig. 1).
During the early phase of treatment, the multidisciplinary therapy (MDT) team should determine whether the metastatic lesions and the primary tumor are curable. Usually, systemic therapy is first administered to determine treatment responses and the biological behavior of the tumors before radical treatment on all lesions in patients who can technically achieve NED. For patients who cannot achieve NED, it is recommended that a decision be made on whether management of local lesions (including primary tumor or local recurrence) should be conducted under the guidance of the MDT team when good systemic disease control is achieved (Fig. 1). During treatment, the biological behavior of tumors, treatment responses, and extrapulmonary metastases should be monitored and timely adjustment to treatment expectations and regimen be conducted.
Even though lung metastases develop slowly and are usually not the primary factors affecting survival and prognosis, the MDT team should be alerted of the possibility of lymphangitic carcinomatosis. This type of intrapulmonary metastases has extremely poor outcomes, and local treatment is usually not recommended for this population of patients. Systemic therapy is the mainstay treatment, and the drugs used should be determined according to the patient’s medical history, physical status, and genetic status so that the most effective drug regimens can be selected. In addition, if emergencies such as bleeding, perforation, and obstruction in the primary tumor or local recurrent lesion occur during diagnosis and treatment, then it is recommended that these emergency complications be managed (e.g., surgical resection, stent implantation, or colostomy) before the patients are treated according to the management procedure for asymptomatic patients. The subsequent discussions will focus on patients with no emergency complications relating to primary/local recurrent lesions.
High-level clinical evidence is limited; therefore, this consensus encourages Chinese oncologists to conduct multicenter clinical studies and encourages individual centers to participate in these future multicenter trials. This consensus also encourages individual cancer centers to include every patient with oligometastatic disease and MDT in a prospectively created registry for quality control and future outcome analysis.
Management of synchronous lung metastases
Management of isolated and resectable lung metastases
Around 9.4–12.2% of patients with lung metastases are suitable for local radical treatment [2, 11], which includes R0 surgery, radiotherapy, and ablation therapy. Even though there are no mature randomized controlled trials, surgery is regarded as the local treatment method with the clearest benefit. Most retrospective studies have found that surgery is superior to chemotherapy alone. After resection of the intrapulmonary lesions, the 5-year survival rate is 35–70% and the 10-year survival rate is 20–30% [24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42] but the 5-year survival rate for patients who received chemotherapy alone is only around 20% . Therefore, it is recommended that aggressive surgical resection be conducted on patients with resectable lung metastases. Radiotherapy and ablation therapy can be considered as alternative measures for patients who are not suitable for surgery due to tumor site, expected residual lung function, patient tolerance, or patient willingness .
Principles of surgical resection
Generally, the first choice for resection of lung metastases is sublobar resection such as wedge resection or segmental resection of the lung. However, under some rare circumstances, pulmonary lobectomy can be conducted as a last resort when the tumor is deep or when there is massive intraoperative bleeding. Patients who receive pulmonary lobectomy have relatively poor prognosis. Even if R0 surgery is conducted, patients with the following factors will have poor prognosis: multiple lung metastases, hilar or mediastinal lymph node metastases, preoperative CEA elevations, large metastatic lesions, shorter disease-free interval (DFI), older age, advanced primary tumor stage, rectal primary tumor, and non-R0 surgery (Table 1).
For patients with no suspected hilar/mediastinal lymph node metastasis in preoperative examinations, routine lymph node dissection during surgery is not required. If lymph node metastases are suspected, then lymph node biopsy or dissection can be considered during surgery.
For resectable lung metastases, the goal of perioperative treatment is to increase the R0 resection rate and decrease the risk of postoperative recurrence. Preoperative systemic therapy can also aid in determining the biological behavior of the tumors. However, there is currently insufficient clinical trial data on preoperative drug treatment in CRC lung metastases, so it is not clear whether this will improve the disease-free survival (DFS) and overall survival (OS) of patients.
For rectal cancer, no studies on perioperative treatment in synchronous lung metastases have been performed to date. It is recommended that sufficient systemic therapy be conducted before surgery for primary tumors and lung metastases and preoperative neoadjuvant rectal radiotherapy be conducted for patients with T3–4 or N+ middle or lower rectal cancer. After surgery, the entire perioperative treatment duration of less than 6 months can be completed according to the tumor response of preoperative treatment and the patient’s physical condition. For rectal cancer patients who did not undergo preoperative treatment, it is recommended that up to 6 months of combined oxaliplatin-based chemotherapy ± radiotherapy be conducted after surgery according to extrapolation of results from the IDEA study (only colon cancer involved) and the SCOT study (both colon cancer and rectal cancer involved) [45, 46]. The specific implementation protocol should be performed under the guidance of an MDT team (Table 2).
Non-surgical local treatment measures can be considered for resectable lung metastases in patients who are not suitable for or refuse surgery. These measures mainly include stereotactic body radiation therapy (SBRT) and ablation therapy. Similar to the principles of surgical treatment, the status of the primary lesion must be assessed before SBRT or ablation therapy and these treatments should be conducted under conditions in which there is good overall tumor control. The principles of systemic therapy are similar to those of perioperative treatment. For single lung metastases, radiofrequency ablation should be first considered when the lesion is located at the outer zone. If the lesion is located at the middle zone, then both radiofrequency ablation and radiotherapy can be considered; and if the lesion is located in the inner zone or near blood vessels, then radiotherapy should be considered first . For multiple lung metastases, a corresponding treatment method can be decided after multidisciplinary discussion.
Management of isolated and potentially resectable lung metastases
Currently, there is no clear definition of “potentially resectable lung metastases.” In most patients who initially have unresectable lung metastases, the reasons for unresectability are widespread distribution of lung metastases and a large number of lung metastases. However, in a minority of patients, the reason is the location or size of the metastatic lesions, or that the metastatic lesions are close to the hilus of the lung or important blood vessels or organs. These patients may achieve the opportunity to undergo R0 surgery through intensive conversion therapy. A small-sample study showed that the conversion rate of lung metastases is 5.7–7.1% [47, 48] (Table 3).
Management of isolated and unresectable lung metastases
Palliative treatment should be conducted on patients with unresectable lung metastases and includes systemic therapy and palliative local treatment. Treatment goals and drug toxicity should be fully considered for systemic therapy . Combination chemotherapy or monochemotherapy ± targeted therapy can be considered. Regular follow-up can be considered for asymptomatic patients with isolated lung metastases, particularly patients with small metastases (e.g., lesions < 1 cm) and good prognosis. Regorafenib may be a choice after failure with first-line and second-line treatment . Please refer to the 2017 National Health and Family Planning Commission Chinese Protocol of Diagnosis and Treatment of Colorectal Cancer for specific drug options . As some patients with lung metastases may have a long survival duration, the gene status of the metastatic lesions might change and thus influence further systemic therapy outcomes after undergoing multiple lines of treatment or a long treatment duration. When possible, re-biopsy of the intrapulmonary lesions or liquid biopsy can be conducted when disease progression occurs to fully understand gene status in the tumor .
Management of lung metastases with extrapulmonary metastases at any other sites
Lung metastasis is the subtype with the best prognosis among metastasis types . Therefore, when lung metastases are accompanied by distal metastases at any other site, these other distal metastases are usually the main consideration for treatment, except when the burden of lung metastases is large and the patient is symptomatic. Thus, this consensus uses liver metastases as an example for corresponding recommendations (Table 4). Treatments for metastases at other sites should refer to the treatments outlined for liver metastases here. For potentially resectable or unresectable metastatic lesions, if these lesions can be converted to resectable by treatment, then they should be included in corresponding routes for management.
If there are ≥ 2 other metastasis sites in addition to lung metastases, then this condition is no longer considered to be oligometastases. This consensus recommends systemic palliative therapy be the main approach. During treatment, MDT team discussions should be conducted to determine whether to use local treatment according to drug efficacy and the biological behavior of the tumors (Table 5).
Resectability assessment of multi-organ metastatic lesions (including lung metastases), selection of surgery timing, and comprehensive therapy require MDT team discussion before determining the treatment strategy. With regard to the colorectal primary tumor and multi-organ metastases, the assessment method is listed in Table 6.
Currently, it is believed that chemotherapy combined with targeted therapy cannot convert initially unresectable multi-organ metastases (including lung metastases) to resectable multi-organ metastases. However, a minority of patients who are particularly sensitive to chemotherapy or chemotherapy combined with targeted therapy may undergo successful conversion.
Management of special situations in rectal cancer with synchronous lung metastases
After locally advanced (T3–4 or N+) middle or lower (≤ 10 cm from the anal margin) rectal cancer has been treated with neoadjuvant therapy, particularly total neoadjuvant therapy (TNT), good long-term control can be achieved for the primary tumor, with a pathological complete response (pCR) of 25–30%. Even though there is a lack of data from large-sample clinical studies for neoadjuvant radiochemotherapy efficacy and strategy in metastatic middle and lower rectal cancer, surgery of middle and lower rectal cancer may significantly affect quality of life (e.g., postoperative complication, stoma care). Therefore, with regard to locally resectable middle and lower rectal cancer with synchronous lung metastases, the following recommendations are made for the management of the primary tumor: When the treatment goal is NED, it is recommended that preoperative systemic therapy and neoadjuvant radiotherapy for the primary tumor be conducted before radical resection of the primary tumor and metastatic lesions. The management order for the primary tumor and metastatic lesions requires MDT team discussion. If the patient has a strong intention for organ preservation and refuses surgery, radical resection of the metastatic lesions can be conducted after TNT treatment and the status of the primary tumor should be closely monitored during follow-up.
Management of initial metachronous lung metastases
Initial metachronous lung metastases mainly include lung metastases that appear during the planned neoadjuvant treatment period or after resection of the primary tumor. Please refer to the corresponding section in synchronous lung metastases for the former situation. With regard to the latter situation, if this is accompanied by local recurrence and the local recurrent lesion is resectable, then the local recurrence lesion should be considered as a “primary lesion” and management should be conducted according to “synchronous lung metastases.” If the local recurrent lesion is unresectable, then this should be considered as an unresectable metastatic lesion and management should be conducted according to the route in Fig. 1. The overall treatment principles are similar to synchronous lung metastases, which will not be discussed here. In this section, we will only discuss perioperative treatment for isolated resectable lung metastases.
This consensus recommends that patients who meet the criteria for resection undergo surgery as the initial treatment [11, 50, 51]. Because perioperative therapy may be superior to surgery alone, postoperative chemotherapy is reasonable and the regimens should be made based on treatments for locally advanced CRC, with oxaliplatin-based treatments being recommended. If preoperative neoadjuvant therapy is an irinotecan-based chemotherapy regimen, then the original regimen can be continued as postoperative adjuvant therapy in patients in which the treatment is effective. The total duration of perioperative chemotherapy should not exceed 6 months [19, 31, 50, 52,53,54].
Regular follow-up is recommended after NED achieved with local ablative treatment in CRC with lung metastases. Plain or enhanced chest CT scan should be conducted once every 6 months for 3 years, and then once a year, for a total of 5 years. Other post-treatment surveillance is referred to Chinese Protocol of Diagnosis and Treatment of Colorectal Cancer .
Conclusion and perspective
In conclusion, this consensus is based on Chinese oncologists’ opinions and limited clinical evidence. We recognized the urgency to conduct randomized prospective controlled clinical studies in the management of CRC lung metastasis. In summary, we hope this consensus provides guidance in treating CRC lung metastasis and encourage in this field.
Metastatic colorectal cancer
No evidence of disease
Pathological complete response
Stereotactic body radiation therapy
Total neoadjuvant therapy
Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ, He J. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66:115–32.
Wang Z, Wang X, Yuan J, Zhang X, Zhou J, Lu M, Liu D, Li J, Shen L. Survival benefit of palliative local treatments and efficacy of different pharmacotherapies in colorectal cancer with lung metastasis: results from a large retrospective study. Clin Colorectal Cancer. 2018;17:e233–55.
Mitry E, Guiu B, Cosconea S, Jooste V, Faivre J, Bouvier AM. Epidemiology, management and prognosis of colorectal cancer with lung metastases: a 30-year population-based study. Gut. 2010;59:1383–8.
Nordholm-Carstensen A, Krarup PM, Jorgensen LN, Wille-Jorgensen PA, Harling H, On behalf of Danish colorectal Cancer group. Occurrence and survival of synchronous pulmonary metastases in colorectal cancer: a nationwide cohort study. Eur J Cancer. 2014;50:447–56.
Chen Q, Liu Z, Cheng L, Song G, Sun X, Zheng R, Zhang S, Chen W. An analysis of incidence and mortality of colorectal cancer in China, 2003~2007. China Cancer. 2012;21:179–82 (In Chinese).
Du L, Li H, Wang Y, Zhu C, Zheng R, Zhang S, Chen W, He J. Report of colorectal cancer incidence and mortality in China, 2013. Chin J Oncol. 2017;39:701–6 (In Chinese).
Siegel R, Desantis C, Jemal A. Colorectal cancer statistics, 2014. CA Cancer J Clin. 2014;64:104–17.
Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RGS, Barzi A, Jemal A. Colorectal cancer statistics, 2017. CA Cancer J Clin. 2017;67:177–93.
Prasanna T, Craft PS, Chua YJ, Karapetis CS, Gibbs P, Wong R, Tie J, Roder D, Price TJ, Padbury R, et al. The outcome of patients (pts) with metastatic colorectal cancer (mCRC) based on site of metastases (mets) and the impact of molecular markers and site of primary cancer on metastatic pattern. J Clin Oncol. 2017;35:abstr 3560.
Section of Gastrointestinal Surgery of Branch of Surgery of Chinese Medical Association, Section of Colorectal Surgery of Branch of Surgery of Chinese Medical Association, Chinese Society of Colon Cancer of China Anti-cancer Association, Chinese Society of Colon and Rectal Surgeons of Branch of Surgeons of Chinese Medical Doctor Association, Chinese Society of Tumor Metastasis of Branch of Anal Surgeons of Chinese Medical Doctor Association, Chinese Society of Colon and Rectal Tumors of Chinese Medical Doctor Association, Committee of Colorectal Experts of Chinese Society of Clinical Oncology, Professional Committee of Treatment for Colorectal Cancer Liver Metastasis of China International Exchange and Promotive Association for Medical and Healthcare. Guideline for the diagnosis and comprehensive treatment of colorectal cancer liver metastasis (2018 edition). Chin J Digest Surg. 2018;17:527–39 (In Chinese).
Tampellini M, Ottone A, Bellini E, Alabiso I, Baratelli C, Bitossi R, Brizzi MP, Ferrero A, Sperti E, Leone F, et al. The role of lung metastasis resection in improving outcome of colorectal cancer patients: results from a large retrospective study. Oncologist. 2012;17:1430–8.
Watanabe K, Saito N, Sugito M, Ito M, Kobayashi A, Nishizawa Y. Incidence and predictive factors for pulmonary metastases after curative resection of colon cancer. Ann Surg Oncol. 2013;20:1374–80.
Moorcraft SY, Ladas G, Bowcock A, Chau I. Management of resectable colorectal lung metastases. Clin Exp Metastasis. 2016;33:285–96.
Nordholm-Carstensen A, Wille-Jorgensen PA, Jorgensen LN, Harling H. Indeterminate pulmonary nodules at colorectal cancer staging: a systematic review of predictive parameters for malignancy. Ann Surg Oncol. 2013;20:4022–30.
Nordholm-Carstensen A, Jorgensen LN, Wille-Jorgensen PA, Hansen H, Harling H. Indeterminate pulmonary nodules in colorectal-cancer: do radiologists agree? Ann Surg Oncol. 2015;22:543–9.
Chiang JM, Hsieh PS, Chen JS, Tang R, You JF, Yeh CY. Rectal cancer level significantly affects rates and patterns of distant metastases among rectal cancer patients post curative-intent surgery without neoadjuvant therapy. World J Surg Oncol. 2014;12:197.
Kim CH, Huh JW, Kim HR, Kim YJ. Indeterminate pulmonary nodules in colorectal cancer: follow-up guidelines based on a risk predictive model. Ann Surg. 2015;261:1145–52.
Brent A, Talbot R, Coyne J, Nash G. Should indeterminate lung lesions reported on staging CT scans influence the management of patients with colorectal cancer? Color Dis. 2007;9:816–8.
Baek SJ, Kim SH, Kwak JM, Cho JS, Shin JW, Amar AH, Kim J. Indeterminate pulmonary nodules in rectal cancer: a recommendation for follow-up guidelines. J Surg Oncol. 2012;106:481–5.
Jung EJ, Kim SR, Ryu CG, Paik JH, Yi JG, Hwang DY. Indeterminate pulmonary nodules in colorectal cancer. World J Gastroenterol. 2015;21:2967–72.
Zheng J, Shen D, Xue W. Rosai and Ackerman’s surgical pathology (tenth edition) (author: Juan Rosai). Beijing: Peking University Medical Press; 2014. (In Chinese)
Hospital Authority of National Health and Family Planning Commission of the People’s Republic of China, Chinese Society of Oncology. Chinese protocol of diagnosis and treatment of colorectal cancer. Chin J Surg. 2018;56:241–58 (In Chinese).
Siravegna G, Marsoni S, Siena S, Bardelli A. Integrating liquid biopsies into the management of cancer. Nat Rev Clin Oncol. 2017;14:531–48.
Cho S, Song IH, Yang HC, Jheon S. Prognostic factors of pulmonary metastasis from colorectal carcinoma. Interact Cardiovasc Thorac Surg. 2013;17:303–7.
Bolukbas S, Sponholz S, Kudelin N, Eberlein M, Schirren J. Risk factors for lymph node metastases and prognosticators of survival in patients undergoing pulmonary metastasectomy for colorectal cancer. Ann Thorac Surg. 2014;97:1926–32.
Borasio P, Gisabella M, Bille A, Righi L, Longo M, Tampellini M, Ardissone F. Role of surgical resection in colorectal lung metastases: analysis of 137 patients. Int J Color Dis. 2011;26:183–90.
Chao YK, Chang HC, Wu YC, Liu YH, Hsieh MJ, Chiang JM, Liu HP. Management of lung metastases from colorectal cancer: video-assisted thoracoscopic surgery versus thoracotomy--a case-matched study. Thorac Cardiovasc Surg. 2012;60:398–404.
Chen F, Hanaoka N, Sato K, Fujinaga T, Sonobe M, Shoji T, Sakai H, Miyahara R, Bando T, Okubo K, et al. Prognostic factors of pulmonary metastasectomy for colorectal carcinomas. World J Surg. 2009;33:505–11.
Cho JH, Kim S, Namgung M, Choi YS, Kim HK, Zo JI, Shim YM, Kim J. The prognostic importance of the number of metastases in pulmonary metastasectomy of colorectal cancer. World J Surg Oncol. 2015;13:222.
Cho JH, Hamaji M, Allen MS, Cassivi SD, Nichols FC 3rd, Wigle DA, Shen KR, Deschamps C. The prognosis of pulmonary metastasectomy depends on the location of the primary colorectal cancer. Ann Thorac Surg. 2014;98:1231–7.
Gonzalez M, Poncet A, Combescure C, Robert J, Ris HB, Gervaz P. Risk factors for survival after lung metastasectomy in colorectal cancer patients: a systematic review and meta-analysis. Ann Surg Oncol. 2013;20:572–9.
Hamaji M, Cassivi SD, Shen KR, Allen MS, Nichols FC, Deschamps C, Wigle DA. Is lymph node dissection required in pulmonary metastasectomy for colorectal adenocarcinoma? Ann Thorac Surg. 2012;94:1796–800.
Iida T, Nomori H, Shiba M, Nakajima J, Okumura S, Horio H, Matsuguma H, Ikeda N, Yoshino I, Ozeki Y, et al. Prognostic factors after pulmonary metastasectomy for colorectal cancer and rationale for determining surgical indications: a retrospective analysis. Ann Surg. 2013;257:1059–64.
Iizasa T, Suzuki M, Yoshida S, Motohashi S, Yasufuku K, Iyoda A, Shibuya K, Hiroshima K, Nakatani Y, Fujisawa T. Prediction of prognosis and surgical indications for pulmonary metastasectomy from colorectal cancer. Ann Thorac Surg. 2006;82:254–60.
Kanemitsu Y, Kato T, Hirai T, Yasui K. Preoperative probability model for predicting overall survival after resection of pulmonary metastases from colorectal cancer. Br J Surg. 2004;91:112–20.
Pfannschmidt J, Dienemann H, Hoffmann H. Surgical resection of pulmonary metastases from colorectal cancer: a systematic review of published series. Ann Thorac Surg. 2007;84:324–38.
Pfannschmidt J, Muley T, Hoffmann H, Dienemann H. Prognostic factors and survival after complete resection of pulmonary metastases from colorectal carcinoma: experiences in 167 patients. J Thorac Cardiovasc Surg. 2003;126:732–9.
Riquet M, Foucault C, Cazes A, Mitry E, Dujon A, Le Pimpec Barthes F, Medioni J, Rougier P. Pulmonary resection for metastases of colorectal adenocarcinoma. Ann Thorac Surg. 2010;89:375–80.
Saito Y, Omiya H, Kohno K, Kobayashi T, Itoi K, Teramachi M, Sasaki M, Suzuki H, Takao H, Nakade M. Pulmonary metastasectomy for 165 patients with colorectal carcinoma: a prognostic assessment. J Thorac Cardiovasc Surg. 2002;124:1007–13.
Vogelsang H, Haas S, Hierholzer C, Berger U, Siewert JR, Präuer H. Factors influencing survival after resection of pulmonary metastases from colorectal cancer. Br J Surg. 2004;91:1066–71.
Watanabe K, Nagai K, Kobayashi A, Sugito M, Saito N. Factors influencing survival after complete resection of pulmonary metastases from colorectal cancer. Br J Surg. 2009;96:1058–65.
Younes RN, Abrao F, Gross J. Pulmonary metastasectomy for colorectal cancer: long-term survival and prognostic factors. Int J Surg. 2013;11:244–8.
Heinemann V, von Weikersthal LF, Decker T, Kiani A, Vehling-Kaiser U, Al-Batran SE, Heintges T, Lerchenmüller C, Kahl C, Seipelt G, et al. FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial. Lancet Oncol. 2014;15:1065–75.
Ibrahim T, Tselikas L, Yazbeck C, Kattan J. Systemic versus local therapies for colorectal cancer pulmonary metastasis: what to choose and when? J Gastrointest Cancer. 2016;47:223–31.
Grothey A, Sobrero AF, Shields AF, Yoshino T, Paul J, Taieb J, Souglakos J, Shi Q, Kerr R, Labianca R, et al. Duration of adjuvant chemotherapy for stage III colon cancer. N Engl J Med. 2018;378:1177–88.
Iveson T, Kerr R, Saunders M, Hollander N, Tabernero J, Haydon A, Glimelius B, Harkin A, Scudder C, Boyd K, et al. Updated results of the SCOT study: an international phase III randomised (1:1) non-inferiority trial comparing 3 versus 6 months of oxaliplatin based adjuvant chemotherapy for colorectal cancer. Ann Oncol. 2017;28:LBA22.
Nozawa H, Ishihara S, Kawai K, Hata K, Kiyomatsu T, Tanaka T, Nishikawa T, Otani K, Yasuda K, Sasaki K, et al. Characterization of conversion chemotherapy for secondary surgical resection in colorectal cancer patients with lung metastases. Oncology. 2017;92:135–41.
Li WH. Oncological outcome of unresectable lung metastases without extrapulmonary metastases in colorectal cancer. World J Gastroenterol. 2010;16:3318.
Martinelli E, Sforza V, Cardone C, Capasso A, Nappi A, Martini G, Napolitano S, Rachiglio AM, Normanno N, Cappabianca S, et al. Clinical outcome and molecular characterisation of chemorefractory metastatic colorectal cancer patients with long-term efficacy of regorafenib treatment. ESMO Open. 2017;2:e000177.
Hawkes EA, Ladas G, Cunningham D, Nicholson AG, Wassilew K, Barbachano Y, Ratnayake G, Rao S, Chau I. Peri-operative chemotherapy in the management of resectable colorectal cancer pulmonary metastases. BMC Cancer. 2012;12:326.
Subbiah IM, Blackmon SH, Correa AM, Kee B, Vaporciyan AA, Swisher SG, Eng C. Preoperative chemotherapy prior to pulmonary metastasectomy in surgically resected primary colorectal carcinoma. Oncotarget. 2014;5:6584–93.
Rama N, Monteiro A, Bernardo JE, Eugenio L, Antunes MJ. Lung metastases from colorectal cancer: surgical resection and prognostic factors. Eur J Cardiothorac Surg. 2009;35:444–9.
Suzuki H, Kiyoshima M, Kitahara M, Asato Y, Amemiya R. Long-term outcomes after surgical resection of pulmonary metastases from colorectal cancer. Ann Thorac Surg. 2015;99:435–40.
Zabaleta J, Aguinagalde B, Izquierdo JM, Bazterargui N, Laguna SM, Martin-Arruti M, Lobo C, Emparanza JI. The presence of mutations in the K-RAS gene does not affect survival after resection of pulmonary metastases from colorectal cancer. ISRN Surg. 2014;2014:157586.
Gonzalez M, Ris HB, Krueger T, Gervaz P. Colorectal cancer and thoracic surgeons: close encounters of the third kind. Expert Rev Anticancer Ther. 2012;12:495–503.
Ricco A, Davis J, Rate W, Yang J, Perry D, Pablo J, D'Ambrosio D, Sharma S, Sundararaman S, Kolker J, et al. Lung metastases treated with stereotactic body radiotherapy: the RSSearch(R) patient Registry’s experience. Radiat Oncol. 2017;12:35.
Osti MF, Carnevale A, Valeriani M, De Sanctis V, Minniti G, Cortesi E, Martelli M, Maurizi ER. Clinical outcomes of single dose stereotactic radiotherapy for lung metastases. Clin Lung Cancer. 2013;14:699–703.
Navarria P, Ascolese AM, Tomatis S, Cozzi L, De Rose F, Mancosu P, Alongi F, Clerici E, Lobefalo F, Tozzi A, et al. Stereotactic body radiotherapy (sbrt) in lung oligometastatic patients: role of local treatments. Radiat Oncol. 2014;9:91.
de Baère T, Aupérin A, Deschamps F, Chevallier P, Gaubert Y, Boige V, Fonck M, Escudier B, Palussiére J. Radiofrequency ablation is a valid treatment option for lung metastases: experience in 566 patients with 1037 metastases. Ann Oncol. 2015;26:987–91.
Mise Y, Kopetz S, Mehran RJ, Aloia TA, Conrad C, Brudvik KW, Taggart MW, Vauthey JN. Is complete liver resection without resection of synchronous lung metastases justified? Ann Surg Oncol. 2015;22:1585–92.
Floriani I, Torri V, Rulli E, Garavaglia D, Compagnoni A, Salvolini L, Giovagnoni A. Performance of imaging modalities in diagnosis of liver metastases from colorectal cancer: a systematic review and meta-analysis. J Magn Reson Imaging. 2010;31:19–31.
Bartolotta TV, Taibbi A, Midiri M, La Grutta L, De Maria M, Lagalla R. Characterisation of focal liver lesions undetermined at grey-scale US: contrast-enhanced US versus 64-row MDCT and MRI with liver-specific contrast agent. Radiol Med. 2010;115:714–31.
Niekel MC, Bipat S, Stoker J. Diagnostic imaging of colorectal liver metastases with CT, MR imaging, FDG PET, and/or FDG PET/CT: a meta-analysis of prospective studies including patients who have not previously undergone treatment. Radiology. 2010;257:674–84.
Kim S, Kim HK, Cho JH, Choi YS, Kim K, Kim J, Zo JI, Shim YM, Heo JS, Lee WY, et al. Prognostic factors after pulmonary metastasectomy of colorectal cancers: influence of liver metastasis. World J Surg Oncol. 2016;14:201.
Adam R, De Gramont A, Figueras J, Guthrie A, Kokudo N, Kunstlinger F, Loyer E, Poston G, Rougier P, Rubbia-Brandt L, et al. The oncosurgery approach to managing liver metastases from colorectal cancer: a multidisciplinary international consensus. Oncologist. 2012;17:1225–39.
Hendlisz A, Golfinopoulos V, Garcia C, Covas A, Emonts P, Ameye L, Paesmans M, Deleporte A, Machiels G, Toussaint E, et al. Serial FDG-PET/CT for early outcome prediction in patients with metastatic colorectal cancer undergoing chemotherapy. Ann Oncol. 2012;23:1687–93.
We would like to thank LetPub (http://www.letpub.com) for English language editorial help.
This work was supported by the National Key Research and Development Program of China (No. 2016YFC0905302).
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Classification of CRC lung metastases. (DOC 33 kb)